892128-60-8

• 常用中文名：LY2334737
• 常用英文名：LY2334737
• CAS号：892128-60-8
• 分子式：C₁₇H₂₅F₂N₃O₅
• 分子量：389.39400
• 相关类别： 信号通路 细胞周期/DNA损伤 核苷抗代谢药/类似物
• 发布时间：2018-11-26 18:16:53
• 更新时间：2026-07-02 11:52:39
• LY2334737是口服活性的gemcitabine原药。

名称

• 中文名: 2'-脱氧-2',2'-二氟-N-(1-氧代-2-丙基戊基)胞苷
• 英文名: N-[1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-oxopyrimidin-4-yl]-2-propylpentanamide
• 中文别名: 化合物:LY2334737; 化合物：LY2334737
• 英文别名: 2'-Deoxy-2',2'-difluoro-N-(1-oxo-2-propylpentyl)cytidine; N-{1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-oxo-1,2-dihydropyrimidin-4-yl}-2-propylpentanamide; unii-ylr364xysa; anticancer,HEV,Gemcitabine,HEVs,HRVs,LY 2334737,EV-A71,Rhinovirus,inhibit,Nucleoside Antimetabolite/Analog,Enterovirus,HRV,orally,LY2334737,LY-2334737,antiviral,Inhibitor; N-(1-((2R,4R,5R)-3,3-Difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)-2-propylpentanamide; Cytidine, 2'-deoxy-2',2'-difluoro-N-(1-oxo-2-propylpentyl); LY2334737, 10 mM in DMSO; LY 2334737;LY-2334737;LY

物化性质

• 分子式: C₁₇H₂₅F₂N₃O₅
• 分子量: 389.39400
• 精确质量: 389.17600
• PSA: 117.17000
• LogP: 1.11830
• 储存条件: 2-8℃

生物活性

• 描述: LY2334737是口服活性的gemcitabine原药。
• 相关类别:
  信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物
  研究领域 >> 癌症
• 参考文献:

  [1]. Pratt SE, et al. Human carboxylesterase-2 hydrolyzes the prodrug of gemcitabine (LY2334737) and confers prodrug sensitivity to cancer cells. Clin Cancer Res. 2013 Mar 1;19(5):1159-68.

  [2]. Koolen SL, et al. Phase I study of Oral gemcitabine prodrug (LY2334737) alone and in combination with erlotinib in patients with advanced solid tumors. Clin Cancer Res. 2011 Sep 15;17(18):6071-82.

  [3]. Francia G, et al. Low-dose metronomic oral dosing of a prodrug of gemcitabine (LY2334737) causes antitumor effects in the absence of inhibition of systemic vasculogenesis. Mol Cancer Ther. 2012 Mar;11(3):680-9.

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