718635-93-9

• 常用中文名：丁苯那嗪外消旋体
• 常用英文名：Tetrabenazine (Racemate)
• CAS号：718635-93-9
• 分子式：C₁₉H₂₇NO₃
• 分子量：317.42300
• 相关类别： 信号通路 跨膜转运 单胺转运蛋白
• 发布时间：2016-03-13 14:24:29
• 更新时间：2026-08-15 08:55:21
• Tetrabenazine (Racemate)是一个有选择性和可逆转的VMAT-2抑制剂。

名称

• 中文名: Tetrabenazine Racemate
• 英文名: Tetrabenazine
• 中文别名: 1尾,4伪-DIBROMOCYCLOHEXANE 99; 川芎嗪杂质10; 3-异丁基-9,10-二甲氧基-3,4,6,7-四氢-1H-吡啶并[2,1-A]异喹啉-2(11BH)-酮; 丁苯那嗪杂质46; 丁苯那嗪杂质10
• 英文别名: Dolalgial; 3-(dimethylamino)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one; TETRABENAZINE RACEMATE;RO 9 RACEMATE; Tetrabenazine Impurity 46; 1,3,4,6,7,11B-HEXAHYDRO-9,10-DIMETHOXY-3-(2-METHYLPROPYL)-2H-BENZO[A]QUINOLIZIN-2-ONE; Tetrabenazine Impurity 10; Tetrabenazine Racemate; Ro 9 Racemate; TETRABENAZINE（b）; rac-Tetrabenazine; Tetrabenazine Racemates (Mixture of Cis - Trance Tetrabenazine); 2H-Benzo[a]quinolizin-2-one, 1,3,4,6,7,11b-hexahydro-9,10-diMethoxy-3-(2-Methylpropyl); 3-Isobutyl-9,10-dimethoxy-3,4,6,7-tetrahydro-1H-pyrido[2,1-a]isoquinolin-2(11bH)-one; Cis Trans Tetrabenazine; 3-isobutyl-9,10-dimethoxy-3,4,6,7-tetrahydro-1H-pyrido[2

物化性质

• 分子式: C₁₉H₂₇NO₃
• 分子量: 317.42300
• 精确质量: 317.19900
• PSA: 38.77000
• LogP: 3.17600
• 外观性状: light yellow solid
• 储存条件: -20℃

生物活性

• 描述: Tetrabenazine (Racemate)是一个有选择性和可逆转的VMAT-2抑制剂。
• 相关类别:
  信号通路 >> 跨膜转运 >> 单胺转运蛋白
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Nunes EJ et al. Effort-related motivational effects of the VMAT-2 inhibitor tetrabenazine: implications for animal models of the motivational symptoms of depression. J Neurosci. 2013 Dec 4;33(49):19120-30.

  [2]. Podurgiel SJ et al. The vesicular monoamine transporter (VMAT-2) inhibitor tetrabenazine induces tremulous jaw movements in rodents: implications for pharmacological models of parkinsonian tremor. Neuroscience. 2013 Oct 10;250:507-19.

  [3]. Reches A et al. Tetrabenazine, an amine-depleting drug, also blocks dopamine receptors in rat brain. J Pharmacol Exp Ther. 1983 Jun;225(3):515-21.