86718-08-3

• 常用中文名：4-(1H-咪唑-1-基)苯甲醇
• 常用英文名：[4-(1H-Imidazol-1-yl)phenyl]methanol
• CAS号：86718-08-3
• 分子式：C₁₀H₁₀N₂O
• 分子量：174.199
• 发布时间：2018-03-25 08:00:00
• 更新时间：2024-01-02 11:44:58

名称

• 中文名: 4-(1-咪唑基)苄醇
• 英文名: [4-(1-Imidazolyl)phenyl]methanol
• 中文别名: 4-(1H-咪唑-1-基)苯甲醇; 4-(1-咪唑基)苯甲醇; 1-(4-羟甲基苯基)咪唑
• 英文别名: Benzenemethanol, 4-(1H-imidazol-1-yl)-; [4-(1H-Imidazol-1-yl)phenyl]methanol; (4-imidazol-1-ylphenyl)methanol; MFCD02682059

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 364.9±25.0 °C at 760 mmHg
• 熔点: 87-89ºC
• 分子式: C₁₀H₁₀N₂O
• 分子量: 174.199
• 闪点: 174.5±23.2 °C
• 精确质量: 174.079315
• PSA: 38.05000
• LogP: 0.80
• 蒸汽压: 0.0±0.9 mmHg at 25°C
• 折射率: 1.605
• 储存条件: 2-8°C

MSDS

Name: [4-(1h-imidazol-1-yl)phenyl]methanol 97% Material Safety Data Sheet Synonym: CAS: 86718-08-3 Section 1 - Chemical Product MSDS Name:[4-(1h-imidazol-1-yl)phenyl]methanol 97% Material Safety Data Sheet Synonym: Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 86718-08-3 [4-(1H-Imidazol-1-yl)phenyl]methanol 97% unlisted Hazard Symbols: XN Risk Phrases: 20/21/22 Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Harmful by inhalation, in contact with skin and if swallowed. Potential Health Effects Eye: May cause eye irritation. Skin: May cause skin irritation. Harmful if absorbed through the skin. Ingestion: Harmful if swallowed. May cause irritation of the digestive tract. Inhalation: Harmful if inhaled. May cause respiratory tract irritation. Chronic: Not available. Section 4 - FIRST AID MEASURES Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Ingestion: Get medical aid. Wash mouth out with water. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Section 7 - HANDLING and STORAGE Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Storage: Store in a cool, dry place. Store in a tightly closed container. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 86718-08-3: Personal Protective Equipment Eyes: Not available. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Solid Color: Not available. Odor: characteristic odor pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: 110 - 112 deg C Autoignition Temperature: Not available. Flash Point: Not available. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Solubility in water: Specific Gravity/Density: Molecular Formula: C10H10N2O Molecular Weight: 174.2 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Not available. Conditions to Avoid: Incompatible materials. Incompatibilities with Other Materials: Strong oxidizing agents. Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide. Hazardous Polymerization: Has not been reported Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 86718-08-3 unlisted. LD50/LC50: Not available. Carcinogenicity: [4-(1H-Imidazol-1-yl)phenyl]methanol - Not listed by ACGIH, IARC, or NTP. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA No information available. IMO No information available. RID/ADR No information available. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: XN Risk Phrases: R 20/21/22 Harmful by inhalation, in contact with skin and if swallowed. Safety Phrases: S 36/37 Wear suitable protective clothing and gloves. WGK (Water Danger/Protection) CAS# 86718-08-3: No information available. Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 86718-08-3 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 86718-08-3 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A

安全

• 危害码 (欧洲): Xn:Harmful;
• 风险声明 (欧洲): R20/21/22
• 安全声明 (欧洲): S36/37
• 海关编码: 2933290090

合成路线

86718-07-2 ~56% 86718-08-3

文献：Artico; Silvestri; Stefancich; Avigliano; Di Giulio; Maccarrone; Agostinelli; Mondovi; Morpurgo European Journal of Medicinal Chemistry, 1992 , vol. 27, # 3 p. 219 - 228

10040-98-9 ~99% 86718-08-3

文献：Battilocchio, Claudio; Hawkins, Joel M.; Ley, Steven V. Organic Letters, 2013 , vol. 15, # 9 p. 2278 - 2281

101184-08-1 ~98% 86718-08-3

文献：Merck and Co., Inc. Patent: US5206240 A1, 1993 ; US 5206240 A

288-32-4 18282-51-4 ~59% 86718-08-3

文献：Zhu, Liangbo; Li, Gaocan; Luo, Liang; Guo, Peng; Lan, Jingbo; You, Jingsong Journal of Organic Chemistry, 2009 , vol. 74, # 5 p. 2200 - 2202

288-32-4 873-75-6 ~79% 86718-08-3

文献：Chen, Huaming; Wang, Deping; Wang, Xianyang; Huang, Wenlong; Cai, Qian; Ding, Ke Synthesis, 2010 , # 9 art. no. F22909SS, p. 1505 - 1511

451-46-7 ~% 86718-08-3

文献：European Journal of Medicinal Chemistry, , vol. 27, # 3 p. 219 - 228

上下游产品

上游产品  7
86718-07-2 10040-98-9 101184-08-1 288-32-4
18282-51-4 873-75-6 451-46-7
下游产品  2
10040-98-9 86718-09-4

海关

海关编码	2933290090
中文概述	2933290090. 其他结构含非稠合咪唑环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%