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上海化源世纪贸易有限公司
上海市上海市普陀区
产品名：普罗喹宗
纯度：95.0%
规格：
联系人：徐经理
联系电话：13311869306

上海创赛科技有限公司
上海市上海市嘉定区
产品名：[Perfemiker]普罗喹宗,95%
纯度：95.0%
规格：5mg/1mg
联系人：夏言
联系电话：18016376636

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22760-18-5生产厂家

22760-18-5价格

22760-18-5

22760-18-5结构式

常用中文名：普罗喹宗
常用英文名：proquazone
CAS号：22760-18-5
分子式：C₁₈H₁₈N₂O
分子量：278.34800
发布时间：2018-03-03 08:00:00
更新时间：2024-01-07 11:33:53

化源商城直购

中文名	普罗喹宗
英文名	7-methyl-4-phenyl-1-propan-2-ylquinazolin-2-one
英文别名	EINECS 245-203-7 Sandoz 43-715 7-methyl-1-isopropyl-4-phenyl-quinazolin-2(1H)-one Proquazonum [INN-Latin] 1-Isopropyl-4-phenyl-7-methyl-2(1H)-quinazolinone 7-methyl-1-isopropyl-4-phenyl-2(1H)-quinazolinone Biarison 1-isopropyl-7-methyl-4-phenyl-quinazolin-2(1H)-one PROQUAZONE 1-isopropyl-7-methyl-4-phenyl-1H-quinazolin-2-one Proquazona [INN-Spanish] SaH 43-715 Arthrex

密度	1.12g/cm3
沸点	440.6ºC at 760mmHg
熔点	137-138 °C
分子式	C₁₈H₁₈N₂O
分子量	278.34800
闪点	220.3ºC
精确质量	278.14200
PSA	34.89000
LogP	3.95280
蒸汽压	5.79E-08mmHg at 25°C
折射率	1.605
储存条件	2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VA3530000

CHEMICAL NAME :: 2(1H)-Quinazolinone, 1-isopropyl-7-methyl-4-phenyl-

CAS REGISTRY NUMBER :: 22760-18-5

BEILSTEIN REFERENCE NO. :: 0889725

LAST UPDATED :: 199612

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C18-H18-N2-O

MOLECULAR WEIGHT :: 278.38

WISWESSER LINE NOTATION :: T66 BNVNJ BY1&1 ER& I1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 759 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - ptosis Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity)

REFERENCE :: DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 3,361,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 375 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - ptosis Behavioral - altered sleep time (including change in righting reflex) Behavioral - antipsychotic

REFERENCE :: DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 3,361,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 930 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - ptosis Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity)

REFERENCE :: DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 3,361,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 339 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay)

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 34,879,1984

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >800 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - ptosis Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity)

REFERENCE :: DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 3,361,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 260 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - ptosis Behavioral - altered sleep time (including change in righting reflex) Behavioral - antipsychotic

REFERENCE :: DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 3,361,1980 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 9100 mg/kg/13W-C

TOXIC EFFECTS :: Gastrointestinal - other changes Related to Chronic Data - death

REFERENCE :: DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 3,361,1980

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - pig

DOSE/DURATION :: 6916 mg/kg/26W-C

TOXIC EFFECTS :: Gastrointestinal - ulceration or bleeding from stomach Blood - changes in erythrocyte (RBC) count Related to Chronic Data - death

REFERENCE :: DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 3,361,1980

海关编码	2933990090

40235-08-3结构式

40235-08-3

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22760-18-5结构式

22760-18-5

文献：US3996227 A1, ;

23070-81-7结构式

23070-81-7

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22760-18-5结构式

22760-18-5

文献：US4236006 A1, ;

598-55-0结构式

598-55-0

23070-81-7结构式

23070-81-7

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22760-18-5结构式

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文献：US4236006 A1, ;

上游产品 2
23070-81-7 598-55-0
下游产品 0

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%