22760-18-5

• 常用中文名：普罗喹宗
• 常用英文名：proquazone
• CAS号：22760-18-5
• 分子式：C₁₈H₁₈N₂O
• 分子量：278.34800
• 发布时间：2018-03-03 08:00:00
• 更新时间：2024-01-07 11:33:53

名称

• 中文名: 普罗喹宗
• 英文名: 7-methyl-4-phenyl-1-propan-2-ylquinazolin-2-one
• 英文别名: EINECS 245-203-7; Sandoz 43-715; 7-methyl-1-isopropyl-4-phenyl-quinazolin-2(1H)-one; Proquazonum [INN-Latin]; 1-Isopropyl-4-phenyl-7-methyl-2(1H)-quinazolinone; 7-methyl-1-isopropyl-4-phenyl-2(1H)-quinazolinone; Biarison; 1-isopropyl-7-methyl-4-phenyl-quinazolin-2(1H)-one; PROQUAZONE; 1-isopropyl-7-methyl-4-phenyl-1H-quinazolin-2-one; Proquazona [INN-Spanish]; SaH 43-715; Arthrex

物化性质

• 密度: 1.12g/cm3
• 沸点: 440.6ºC at 760mmHg
• 熔点: 137-138 °C
• 分子式: C₁₈H₁₈N₂O
• 分子量: 278.34800
• 闪点: 220.3ºC
• 精确质量: 278.14200
• PSA: 34.89000
• LogP: 3.95280
• 蒸汽压: 5.79E-08mmHg at 25°C
• 折射率: 1.605
• 储存条件: 2-8°C

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : VA3530000 CHEMICAL NAME : 2(1H)-Quinazolinone, 1-isopropyl-7-methyl-4-phenyl- CAS REGISTRY NUMBER : 22760-18-5 BEILSTEIN REFERENCE NO. : 0889725 LAST UPDATED : 199612 DATA ITEMS CITED : 8 MOLECULAR FORMULA : C18-H18-N2-O MOLECULAR WEIGHT : 278.38 WISWESSER LINE NOTATION : T66 BNVNJ BY1&1 ER& I1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 759 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - ptosis Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) REFERENCE : DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 3,361,1980 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 375 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - ptosis Behavioral - altered sleep time (including change in righting reflex) Behavioral - antipsychotic REFERENCE : DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 3,361,1980 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 930 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - ptosis Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) REFERENCE : DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 3,361,1980 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 339 mg/kg TOXIC EFFECTS : Behavioral - general anesthetic Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay) REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 34,879,1984 TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : >800 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - ptosis Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) REFERENCE : DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 3,361,1980 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 260 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - ptosis Behavioral - altered sleep time (including change in righting reflex) Behavioral - antipsychotic REFERENCE : DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 3,361,1980 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 9100 mg/kg/13W-C TOXIC EFFECTS : Gastrointestinal - other changes Related to Chronic Data - death REFERENCE : DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 3,361,1980 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - pig DOSE/DURATION : 6916 mg/kg/26W-C TOXIC EFFECTS : Gastrointestinal - ulceration or bleeding from stomach Blood - changes in erythrocyte (RBC) count Related to Chronic Data - death REFERENCE : DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 3,361,1980

安全

• 海关编码: 2933990090

合成路线

40235-08-3 ~% 22760-18-5

文献：US3996227 A1, ;

23070-81-7 ~% 22760-18-5

文献：US4236006 A1, ;

598-55-0 23070-81-7 ~% 22760-18-5

文献：US4236006 A1, ;

上下游产品

上游产品  2
23070-81-7 598-55-0
下游产品  0

海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%