61-01-8

• 常用中文名：美索丙嗪
• 常用英文名：methopromazine
• CAS号：61-01-8
• 分子式：C₁₈H₂₂N₂OS
• 分子量：314.44500
• 相关类别： 医药中间体 杂环化合物 嘧啶类化合物 酮类
• 发布时间：2018-09-25 12:32:12
• 更新时间：2024-01-22 14:02:51

名称

• 中文名: 美索丙嗪
• 英文名: 3-(2-methoxyphenothiazin-10-yl)-N,N-dimethylpropan-1-amine
• 英文别名: 2-Methoxypromazine; Methopromazinum [INN-Latin]; Neoproma; [3-(2-methoxy-phenothiazin-10-yl)-propyl]-dimethyl-amine; RP 4632; Methoxypromazine; Tentone; 2-Methoxy-10-(3'-dimethylaminopropyl)phenothiazine; Methopromazine; Tenton; Methopromazin; Metopromazina [INN-Spanish]; Levopromazine; [3-(2-Methoxy-phenothiazin-10-yl)-propyl]-dimethyl-amin

物化性质

• 密度: 1.143g/cm3
• 沸点: 461.8ºC at 760 mmHg
• 分子式: C₁₈H₂₂N₂OS
• 分子量: 314.44500
• 闪点: 233.1ºC
• 精确质量: 314.14500
• PSA: 41.01000
• LogP: 4.31460
• 折射率: 1.603

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : SO7600000 CHEMICAL NAME : Phenothiazine, 10-(3-(dimethylamino)propyl)-2-methoxy CAS REGISTRY NUMBER : 61-01-8 LAST UPDATED : 198209 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C18-H22-N2-O-S MOLECULAR WEIGHT : 314.48 WISWESSER LINE NOTATION : T C666 BN ISJ B3N1&1 EO1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 730 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - respiratory depression REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 125,101,1960 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 95 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - respiratory depression REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 125,101,1960 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 408 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - respiratory depression REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 125,101,1960 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 112 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - respiratory depression REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 125,101,1960 *** REVIEWS *** TOXICOLOGY REVIEW JMSCA9 Journal of Mental Science. (London, UK) V.4-108, 1857-1962. For publisher information, see BJPYAJ. Volume(issue)/page/year: 106,755,1960

合成路线

1771-18-2 109-54-6 ~% 61-01-8

文献：Soc. Usines Chim. Rhone-Poulenc Patent: US2785160 , 1952 ; Full Text Show Details Soc. Usines Chim. Rhone-Poulenc Patent: DE940829 , 1952 ;

107627-98-5 ~% 61-01-8

文献：Soc. Usines Chim. Rhone-Poulenc Patent: US2769002 , 1954 ;

67-56-1 69-09-0 ~0% 61-01-8 53-60-1

文献：Garcia, Carmelo; Pinero, Luis; Oyola, Rolando; Arce, Rafael Photochemistry and Photobiology, 2009 , vol. 85, # 1 p. 160 - 170

上下游产品

上游产品  5
1771-18-2 109-54-6 107627-98-5 67-56-1
69-09-0
下游产品  0