24683-20-3

• 常用中文名：糖精N-(2-乙酸乙酯)(吡罗昔康杂质E)
• 常用英文名：2-((TERT-BUTYLDIMETHYLSILYLOXY)METHYL)-6-((TRIMETHYLSILYL)ETHYNYL)FURO[3,2-B]PYRIDINE
• CAS号：24683-20-3
• 分子式：C₁₁H₁₁NO₅S
• 分子量：269.27400
• 发布时间：2018-08-04 22:41:41
• 更新时间：2025-08-20 01:19:01

名称

• 中文名: 2,3-二氢-3-氧代-1,2-苯并异噻唑-2-乙酸乙酯-1,1-二氧化物
• 英文名: ethyl 2-(1,1,3-trioxo-1,2-benzothiazol-2-yl)acetate
• 中文别名: 沙卡林N-(2-醋酸乙酯)(吡罗昔康杂质 E); 2,3-二氢-3-氧代-1,2-苯异噻唑-2-乙酸乙酯-1,1-二氧化物
• 英文别名: Ethyl (1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)acetate; ethyl 2-(1,1-dioxido-3-oxobenzo[d]isothiazol-2(3H)-yl) acetate; N-carbethoxymethyl-1,2-benzisothiazole-1,1-dioxide-3-one; ethyl (3-oxo-1,2-benzoisothiazol-2(3H)-yl)acetate 1,1-dioxide; UNII-KN712V27AV; ethyl (1,1-dioxido-3-oxo-1,2-benzothiazol-2(3H)-yl)acetate; Piroxicam Impurity E; Piroxicam impurity E [EP]; N-(ethoxycarbonyl)methyl-1,2-benzisothiazol-3(2H)-one 1,1-dioxide; Saccharin N-(2-Acetic Acid Ethyl Ester)(Piroxicam Impurity E); 2-<1,1,3-Trioxo-1,2-benzoisothiazol-2(3H)-yl>essigsaeure-ethylester; Ethyl 1,2-benzisothiazol-3-one-1,1-dioxide-N-acetate

物化性质

• 密度: 1.442g/cm3
• 沸点: 441.4ºC at 760 mmHg
• 分子式: C₁₁H₁₁NO₅S
• 分子量: 269.27400
• 闪点: 220.8ºC
• 精确质量: 269.03600
• PSA: 89.13000
• LogP: 1.41290
• 蒸汽压: 5.45E-08mmHg at 25°C
• 折射率: 1.584

安全

• 海关编码: 2934999090

合成路线

105-36-2 81-07-2 ~78% 24683-20-3

文献：CHIESI FARMACEUTICI S.P.A.; ARMANI, Elisabetta; AMARI, Gabriele; CAPALDI, Carmelida; CARZANIGA, Laura; LA PORTA, Elena; GUALA, Matilde Patent: WO2013/57013 A2, 2013 ; Location in patent: Page/Page column 103; 104 ;

128-44-9 105-39-5 ~89% 24683-20-3

文献：Nikolaev, Vsevolod; Hennig, Lothar; Sieler, Jochim; Rodina, Ludmila; Schulze, Barbel; Nikolaev, Valerij Organic and Biomolecular Chemistry, 2005 , vol. 3, # 22 p. 4108 - 4116

4299-16-5 ~97% 24683-20-3

文献：Sivaramakrishnan, Santhosh; Cummings, Andrea H.; Gates, Kent S. Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 2 p. 444 - 447

128-44-9 685-87-0 ~93% 24683-20-3

文献：Nikolaev, Vsevolod; Hennig, Lothar; Sieler, Jochim; Rodina, Ludmila; Schulze, Barbel; Nikolaev, Valerij Organic and Biomolecular Chemistry, 2005 , vol. 3, # 22 p. 4108 - 4116

105-39-5 81-07-2 ~87% 24683-20-3

文献：Hu, Yi; Chen, Zhen-Chu; Le, Zhang-Gao; Zheng, Qin-Guo Journal of Chemical Research, 2004 , # 4 p. 276 - 278

128-44-9 105-36-2 ~63% 24683-20-3

文献：Da Settimo; Primofiore; La Motta; Simorini; Boldrini; Bianchini Farmaco, 1996 , vol. 51, # 4 p. 261 - 267

118463-44-8 ~% 24683-20-3

文献：Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 27, # 1-12 p. 109 - 111

118463-46-0 ~% 24683-20-3

文献：Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 27, # 1-12 p. 109 - 111

105-39-5 ~% 24683-20-3

文献：Chemische Berichte, , vol. 56, p. 1814

上下游产品

上游产品  8
105-36-2 81-07-2 128-44-9 105-39-5
4299-16-5 685-87-0 118463-44-8 118463-46-0
下游产品  10
35511-14-9 35510-91-9 34258-79-2 35511-63-8
35511-66-1 24683-26-9 24683-25-8 24683-21-4
5510-09-8 52188-11-1

海关

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%