166815-96-9

• 常用中文名：1-N-BOC-4-(4-甲基苯磺酰氧甲基)哌啶
• 常用英文名：tert-Butyl 4-((tosyloxy)methyl)piperidine-1-carboxylate
• CAS号：166815-96-9
• 分子式：C₁₈H₂₇NO₅S
• 分子量：369.476
• 发布时间：2018-08-19 12:12:10
• 更新时间：2025-08-24 22:50:34

名称

• 中文名: N-Boc-4-(4-甲苯磺酰氧基甲基)哌啶
• 英文名: N-Tert-Butoxycarbonyl-4-(4-Toluenesulfonyloxymethyl)Piperidine
• 中文别名: 1-叔丁氧羰基-4-(对二甲苯磺酸基)哌啶; N-Boc-4-(4-甲基苯磺酰氧甲基)哌啶; N-BOC-4-(4-甲基苯磺酸甲基)哌啶; 1-N-BOC-4-(4-甲基苯磺酰氧甲基)哌啶(凡德他尼中间体); 1-BOC-4-对甲苯磺酰氧基哌啶; N-BOC-4-(4-甲基苯磺酰氧甲基)哌啶; 4-[(4-甲基苯基)磺酰氧基甲基]哌啶-1-羧酸叔丁酯; 4-[(4-甲基苯基)磺酰氧基甲基]-1-哌啶-1-羧酸叔丁酯; 4-[[(4-甲苯基磺酰基)氧基]甲基]哌啶-1-羧酸叔丁酯; 1-BOC-4-[(对甲苯磺酰基氧基)甲基]哌啶; 凡德他尼侧链; 1-BOC-4-(P-甲苯磺酰氧甲基)哌啶; 1-BOC-4-(对二甲苯磺酸基)哌啶; N-BOC-4-(4-甲苯磺酰氧基甲基)哌啶; 1-Boc-4-(对二甲苯磺酸基)哌啶; 4-({[(4-甲基苯基)磺酰基]氧基}甲基)哌啶-1-甲酸叔丁酯; 1-BOC-4-(O-对甲苯磺酰基-羟甲基)哌啶; 4-[(4-甲基苯基)磺酰氧基甲基]哌啶-1-甲酸叔丁酯; 1-叔丁氧羰基-4-[(对二甲苯磺酸基)甲基]哌啶
• 英文别名: 1-(tert-Butoxycarbonyl)-4-(tosyloxymethyl)piperidine; 1-Boc-4-(tosyloxyMethyl)piperidine; tert-butyl 4-{[(4-methylbenzenesulfonyl)oxy]methyl}piperidine-1-cboxylate; N-tert-Butoxycbonyl-4-(4-toluenesulfonyloxymethyl)piperidi; 2-Methyl-2-propanyl 4-({[(4-methylphenyl)sulfonyl]oxy}methyl)-1-piperidinecarboxylate; tert-butyl 4-({[(4-methylphenyl)sulfonyl]oxy}methyl)piperidine-1-carboxylate; 1-(tert-Butoxycarbonyl)-4-[(p-toluenesulfonyloxy)methyl]piperidine; 1-N-BOC-4-(4-Methylbenzenesulfonyloxymethyl)piperidine; 4-[[(4-Tolylsulfonyl)oxy]methyl]piperidine-1-cboxylic acid tert-butyl ester; 1-Boc-4-(p-toluenesulfonyloxyMethyl)piperidine; 1-Boc-4-(tosyloxymethyl)piperidine; 166-9; tert-Butyl 4-((tosyloxy)Methyl)piperidine-1-cboxylate; 1-(tert-Butoxycbonyl)-4-[(p-toluenesulfonyloxy)methyl]piperidine>; 4-[(4-methylphenyl)sulfonyloxymethyl]piperidine-1-cboxylic acid tert-butyl ester; 1-piperidinecboxylic acid, 4-[[[(4-methylphenyl)sulfonyl; 1-(tert-Butoxycbonyl)-4-(tosyloxymethyl)piperidine; N-tert-Butoxycbonyl-4-(4-toluenesulphonyloxymethyl)piperidine; N-Boc-4-(4-toluenesulfonyloxymethyl)piperidine; 1-N-bOC-4-(4-TOLUENESULFONYLOXYMETHYL)PIPERIDINE; 1-(tert-Butoxycbonyl)-4-[(p-toluenesulfonyloxy)methyl]piperidine; tert-Butyl 4-((tosyloxy); N-TERT-BUTOXYCBONYL-4-(4-TOLUENESULFONYLOXYMETHYL)PIPERIDINE; 4-[(4-methylphenyl)sulfonyloxymethyl]-1-piperidinecboxylic acid tert-butyl ester; tert-Butyl 4-({[(4-methylphenyl)sulfonyl]-oxy}methyl)piperidine-1-carboxylate; N-(tert-Butoxycbonyl)-4-(tosyloxymethyl)piperidine; 1-Boc-4-(p-toluenesulfonyloxymethyl)piperidine; tert-butyl 4-({[(4-methylphenyl)sulfonyl]oxy}methyl)piperidine-1-cboxylate; 1-Piperidinecarboxylic acid, 4-[[[(4-methylphenyl)sulfonyl]oxy]methyl]-, 1,1-dimethylethyl ester; N-Boc-4-(4-Toluenesulfonyloxymethyl)piperidine; 1-PIPERIDINECBOXYLIC ACID, 4-[[[(4-METHYLPHENYL)SULFONYL]OXY]METHYL]-, 1,1-DIMETHYLETHYL ESTER; N-tert-Butoxycbonyl-4-(4-toluenesulfonyloxymethyl)

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 487.8±18.0 °C at 760 mmHg
• 熔点: 74 °C
• 分子式: C₁₈H₂₇NO₅S
• 分子量: 369.476
• 闪点: 248.8±21.2 °C
• 精确质量: 369.160980
• PSA: 81.29000
• LogP: 2.90
• 外观性状: 固体;White to Orange to Green powder to crystal
• 蒸汽压: 0.0±1.2 mmHg at 25°C
• 折射率: 1.526
• 储存条件: 室温
• 水溶解性: 可溶于：甲醇

安全

• 危害码 (欧洲): Xi
• 海关编码: 2933399090

合成路线

98-59-9 123855-51-6 ~88% 166815-96-9

文献：Chiesi Farmaceutici S.p.A.; RANCATI, Fabio; Rizzi, Andrea; Linney, Ian; Blackaby, Wesley; Knight, Chris Patent: US2013/34504 A1, 2013 ; Location in patent: Paragraph 0147; 0148; 0149 ;

280-57-9 107-83-5 98-59-9 123855-51-6 ~85% 详细

文献：AstraZeneca AB Patent: US7235559 B1, 2007 ; US 7235559 B1

6457-49-4 24424-99-5 98-59-9 ~% 166815-96-9

文献：US5763458 A1, ; US 5763458 A

280-57-9 98-59-9 123855-51-6 ~% 166815-96-9

文献：US2004/48881 A1, ; US 20040048881 A1

6457-49-4 ~% 166815-96-9

文献：Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 42, # 13 p. 1289 - 1300

上下游产品

上游产品  6
98-59-9 123855-51-6 280-57-9 107-83-5
6457-49-4 24424-99-5
下游产品  6
259143-03-8 264208-86-8 338992-20-4 338992-12-4
166815-97-0 906565-52-4

海关

海关编码	2933399090
中文概述	2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%