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| 中文名 | 4,4'-二异硫氰酸基-2,2'-二苯乙烯磺酸二钠 |
|---|---|
| 英文名 | Benzenesulfonic acid, 2,2'-(1,2-ethenediyl)bis[5-isothiocyanato-, disodium salt |
| 中文别名 |
4,4'-二异硫氰酰-2,2'-二磺酸二钠盐
4,4'-二异硫氰酸基二苯乙烯-2,2'-二磺酸二钠盐 |
| 英文别名 |
DisodiuM 4,4'-Diisothiocyanato-2,2'-stilbenedisulfonate
4,4'-DIISOTHIOCYANOSTILBENE-2,2'-DISULFONIC ACID DISODIUM SALT Benzenesulfonic acid, 2,2'-[(E)-1,2-ethenediyl]bis[5-isothiocyanato-, sodium salt (1:2) 4,4'-diisothiocyanato-2,2'-stilbenedisulfonic acid sodium Disodium 2,2'-[(E)-1,2-ethenediyl]bis(5-isothiocyanatobenzenesulfonate) DISODIUM 4,4'-DIISOTHIOCYANATO-2,2'-STILBENEDISULFONATE Hydrate [Protein Modification Reagent] 4,4'-DIISOTHIOCYANOSTILBENE-2,2'-DISULFONIC ACID,2NA PMPA (NMDA antagonist) Disodium 2,2'-(E)-ethene-1,2-diylbis(5-isothiocyanatobenzenesulfonate) DIDS MFCD00009638 DIDS DISODIUM SALT 4,4'-DIISOTHIOCYANATOSTILBENE-2,2'-DISULFONIC A. NA2-SLT HY DIDS sodium salt |
| 描述 | DIDS sodium salt 是 ABCA1 和 VDAC1 的双抑制剂。 |
|---|---|
| 相关类别 | |
| 靶点 |
ABCA1[1], VDAC1[2]. |
| 体外研究 | 浓度小于400μMDIDS对细胞存活率没有明显的细胞毒性作用在100和200μM浓度的DIDS预处理导致ALA-SDT诱导的细胞死亡的预防效果,而50μM的剂量没有抑制作用。在浓度为400μM时,DIDS本身略微降低细胞活力,尽管与未处理对照相比没有显着的统计学差异。 DIDS(100μM)预处理可明显抑制caspase-3和caspase-9的活化[2]。 |
| 细胞实验 | 将细胞（5×10 5个细胞/ mL）接种在35-mm培养皿中并在37℃下培养72小时。将细胞与ALA预孵育，然后在暴露于超声之前加入不同浓度（0-200μM）的DIDS。检测细胞凋亡。简而言之，将接种的细胞（5×10 5个细胞/ mL）用指定浓度的测试化合物预处理1小时（DIDS和NAC），1.5小时（BAPTA）或用siRNA预处理并暴露于超声波。 ALA-SDT治疗后6小时，收集细胞[2]。 |
| 参考文献 |
| 密度 | 1.54g/cm3 |
|---|---|
| 沸点 | 397ºC |
| 分子式 | C16H8N2Na2O6S4 |
| 分子量 | 498.484 |
| 精确质量 | 497.906067 |
| PSA | 214.40000 |
| LogP | 5.98060 |
| 外观性状 | 黄色粉末 |
| 储存条件 | 存放在密封容器内，并放在阴凉，干燥处。储存的地方必须远离氧化剂。冷藏。 |
| 稳定性 | 常温常压下稳定，远离氧化剂。 |
| 计算化学 | 1、 疏水参数计算参考值（XlogP）： 2、 氢键供体数量：0 3、 氢键受体数量：8 4、 可旋转化学键数量：4 5、 拓扑分子极性表面积（TPSA）：139 6、 重原子数量：30 7、 表面电荷：0 8、 复杂度：792 9、 同位素原子数量：0 10、 确定原子立构中心数量：0 11、 不确定原子立构中心数量：0 12、 确定化学键立构中心数量：0 13、 不确定化学键立构中心数量：1 14、 共价键单元数量：3 |
| 更多 | 1. 性状：黄色或者黄绿色粉末。 2. 密度（g/mL,25/4℃）：未确定 3. 相对蒸汽密度（g/mL,空气=1）：未确定 4. 熔点（ºC）：未确定 5. 沸点（ºC,常压）：未确定 6. 沸点（ºC,5.2kPa）：未确定 7. 折射率：未确定 8. 闪点（ºC）：未确定 9. 比旋光度（º）：未确定 10. 自燃点或引燃温度（ºC）：未确定 11. 蒸气压（kPa,25ºC）：未确定 12. 饱和蒸气压（kPa,60ºC）：未确定 13. 燃烧热（KJ/mol）：未确定 14. 临界温度（ºC）：未确定 15. 临界压力（KPa）：未确定 16. 油水（辛醇/水）分配系数的对数值：未确定 17. 爆炸上限（%,V/V）：未确定 18. 爆炸下限（%,V/V）：未确定 19. 溶解性：溶于水。 |
Synonym:4,4'-Diisothiocyanostilbene-2,2'-d-sulfonic acid disodium salt Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
Risk Phrases: None Listed. Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW
Not available. Potential Health Effects Eye: Causes eye irritation. Skin: Causes skin irritation. Ingestion: May cause irritation of the digestive tract. Inhalation: Causes respiratory tract irritation. Chronic: No information found. Section 4 - FIRST AID MEASURES Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Ingestion: If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Antidote: None reported. Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or appropriate foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Avoid generating dusty conditions. Provide ventilation. Section 7 - HANDLING and STORAGE Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Storage: Keep container closed when not in use. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep refrigerated. (Store below 4C/39F.) Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 67483-13-0: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Powder Color: orange to tan Odor: Not available. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: 397 deg C Freezing/Melting Point: Not available. Autoignition Temperature: Not available. Flash Point: Not available. Explosion Limits, lower: N/A Explosion Limits, upper: N/A Decomposition Temperature: Solubility in water: Specific Gravity/Density: Molecular Formula: C16H8N2Na2O6S4 Molecular Weight: 498.48 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable under normal temperatures and pressures. Conditions to Avoid: Incompatible materials, dust generation, strong oxidants. Incompatibilities with Other Materials: Strong oxidizing agents. Hazardous Decomposition Products: Hydrogen cyanide, carbon monoxide, oxides of nitrogen, oxides of sulfur, irritating and toxic fumes and gases, carbon dioxide. Hazardous Polymerization: Will not occur. Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 67483-13-0 unlisted. LD50/LC50: Not available. Carcinogenicity: Dids - Not listed by ACGIH, IARC, or NTP. Section 12 - ECOLOGICAL INFORMATION Other No information available. Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Not regulated as a hazardous material. IMO Not regulated as a hazardous material. RID/ADR Not regulated as a hazardous material. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: Not available. Risk Phrases: Safety Phrases: S 24/25 Avoid contact with skin and eyes. S 28A After contact with skin, wash immediately with plenty of water. S 37 Wear suitable gloves. S 45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). WGK (Water Danger/Protection) CAS# 67483-13-0: No information available. Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 67483-13-0 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 67483-13-0 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A |
| 危害码 (欧洲) | Xn: Harmful; |
|---|---|
| 风险声明 (欧洲) | R36/37/38 |
| 安全声明 (欧洲) | 22-26 |