132622-66-3

• 常用中文名：(2S,4S)-4-氨基-1,2-吡咯烷二羧酸 1-叔丁酯
• 常用英文名：(2S,4S)-4-Amino-1,2-pyrrolidinedicarboxylic acid 1-(tert-butyl) ester
• CAS号：132622-66-3
• 分子式：C₁₀H₁₈N₂O₄
• 分子量：230.26100
• 发布时间：2018-12-31 15:50:17
• 更新时间：2026-07-06 23:31:34

名称

• 中文名: (2S,4S)-4-氨基-1-(叔丁氧羰基)吡咯烷二羧酸
• 英文名: (2S,4S)-1-Boc-4-Aminopyrrolidine-2-carboxylic acid
• 中文别名: (2S,4S-4 -氨基- 1; (S)-(+)-n-boc-4-氨基-l-脯氨酸; 顺式-1-BOC-4-氨基-L-脯氨酸; (S)-(+)-N-BOC-4-氨基-L-脯氨酸; (4S)-4-氨基-1-BOC-L-脯氨酸; (2S,4S)-4 -氨基- 1 -(叔丁氧羰基)吡咯烷二羧酸; (4S)-4-氨基-1-Boc-L-脯氨酸
• 英文别名: (±) cis-4-Amino N-Boc nipecotic acid; (2S,4S)-4-amino-1-[(2-methylpropan-2-yl)oxycbonyl]pyrrolidine-2-cboxylic acid; (2S,4S)-4-Amino-pyrrolidine-1,2-dicboxylic acid 1-tert-butyl ester; cis-4-Amino-1-Boc-2-pyrrolidinecboxylic acid; (2S-cis)-4-amino-1,2-Pyrrolidinedicboxylic acid 1-(tert-butyl) ester; CIS-1-BOC-4-AMINO-L-PROLINE; (2S,4S)-4-amino-1-(tert-butoxycbonyl)pyrrolidine-2-cboxylic acid; (2S,4S)-4-Amino-1,2-pyrrolidinedicboxylic acid 1-(tert-butyl) ester; (2S,4S)-4-amino-1-(tert-butoxycbonyl)pyrrolidinedicboxylic acid; cis-1-(1,1-dimethylethyoxycbonyl)-4-amino-L-proline; (S)-(+)-N-BOC-4-AMINO-L-PROLINE; 2S,4S)-4-amino-1-(tert-butoxycbonyl)pyrrolidine-2-cboxylic a; (2S,4S)-4-Amino-1,2-pyrrolidinedicboxylic Acid 1-(1,1-Dimethylethyl) Ester; 1,2-Pyrrolidinedicboxylic acid, 4-amino-, 1-(1,1-diMethylethyl) ester, (2S,4S); (S)-(+)-N-BOC-4-AMINO-L-PROLINE, 97; (4S)-4-Amino-1-Boc-L-proline; (2S,4S)-4-amino-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid

物化性质

• 密度: 1.232g/cm3
• 沸点: 371.1ºC at 760mmHg
• 熔点: >266ºC(lit.)
• 分子式: C₁₀H₁₈N₂O₄
• 分子量: 230.26100
• 闪点: 178.2ºC
• 精确质量: 230.12700
• PSA: 92.86000
• LogP: 1.04590
• 蒸汽压: 1.59E-06mmHg at 25°C
• 折射率: 1.516
• 储存条件: 室温，干燥

安全

• 危害码 (欧洲): Xi

合成路线

874162-96-6 ~99% 132622-66-3

文献：Zanardi, Franca; Burreddu, Paola; Rassu, Gloria; Auzzas, Luciana; Battistini, Lucia; Curti, Claudio; Sartori, Andrea; Nicastro, Giuseppe; Menchi, Gloria; Cini, Nicoletta; Bottonocetti, Anna; Raspanti, Silvia; Casiraghi, Giovanni Journal of Medicinal Chemistry, 2008 , vol. 51, # 6 p. 1771 - 1782

132622-65-2 ~85% 132622-66-3

文献：Webb, Thomas R.; Eigenbrot, Charles Journal of Organic Chemistry, 1991 , vol. 56, # 9 p. 3009 - 3016

121148-01-4 ~% 132622-66-3

文献：WO2006/20276 A2, ; Page/Page column 352-353 ;

174148-03-9 ~% 132622-66-3

文献：WO2006/116157 A2, ; Page/Page column 117-118 ; WO 2006/116157 A2

865295-35-8 ~% 132622-66-3

文献：Journal of Medicinal Chemistry, , vol. 49, # 1 p. 307 - 317

89813-47-8 ~% 132622-66-3

文献：Journal of Medicinal Chemistry, , vol. 49, # 1 p. 307 - 317

132623-03-1 ~% 132622-66-3

文献：Journal of Organic Chemistry, , vol. 56, # 9 p. 3009 - 3016

上下游产品

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