446292-07-5

• 常用中文名：2-[(2R)-2-羟基-3-[[4-(3-氧代-4-吗啉基)苯基]氨基]丙基]-1H-异吲哚-1,3(2H)-二酮
• 常用英文名：4-[((2R)-Hydroxy-3-phthalimido)propylamine]phenyl-3-morpholinone
• CAS号：446292-07-5
• 分子式：C₂₁H₂₁N₃O₅
• 分子量：395.409
• 发布时间：2018-11-22 15:04:43
• 更新时间：2026-07-10 16:37:27

名称

• 中文名: 2-[(2R)-2-羟基-3-[[4-(3-氧代-4-吗啉)苯基]氨基]丙基]-1H-异吲哚-1,3(2H)-二酮
• 英文名: (R)-2-(2-Hydroxy-3-((4-(3-oxomorpholino)phenyl)amino)propyl)isoindoline-1,3-dione
• 中文别名: 2-[(2R)-2-羟基-3-[[4-(3-氧代-4-吗啉基)苯基]氨基]丙基]-1H-异吲哚-1,3(2H)-二酮,利伐沙班中间体; 2-[(2R)-2-羟基-3-[[4-(3-氧 代-4-吗啉基)苯基]氨基]丙 基]-1H-异吲哚-1,3(2H); 2-[[(2R)-2-羟基-3-[4-(3-氧代-4-吗啉基)苯基]氨基]丙基]-1H-异吲引哚-1,3(2H)-二酮; 利伐沙班中间体B; 化合物 (R)-2-(2-HYDROXY-3-((4-(3-OXOMORPHOLINO)PHENYL)AMINO)PROPYL)ISOINDOLINE-1,3-DIONE; 利伐沙班杂质50; 利伐沙班杂质94; 利伐沙班07; 利伐沙班氧代邻苯二甲酰亚胺脱羰基杂质; 利伐沙班邻苯二甲酰亚胺去羰基杂质; 利伐沙班邻苯二甲酰亚胺基去羰基杂质; 利伐沙班酞酰亚胶二羰基杂质; (R)-2-(2-羟基-3-((4-(3-氧代吗啉)苯基)氨基)丙基)异吲哚啉-1,3-二酮; 氢-异吲哚- 1,3(2H)-二酮,2 - [(2R)的- 2 -羟基- 3 - [[4 - (3 -氧- 4 -吗啉基)苯基]氨基]丙基] -; 利伐沙班酞酰亚胺二羰基杂质; (R)-2-[2-羟基-3-[[4-[3-氧代(4-吗啉基)]苯基]氨基]丙基]异吲哚啉-1,3-二酮; (R) -2-(2-羟基-3-((4-(3-氧代吗啉基)苯基)氨基)丙基)异吲哚啉-1,3-二酮; 利伐沙班杂质RC47; 利伐沙班杂质39; 利伐沙班脱羰基杂质; 立伐沙班中间体B; 氢-异吲哚-1,3(2H)-二酮,2-[(2R)的-2-羟基-3-[[4-(3-氧-4-吗啉基; (R)-2-(2-羟基-3-{[4-(3-氧代-4-吗啉基)苯基]氨基}丙基)-1H-异吲哚-1,3-二酮; (2-[(2R)-2-羟基-3-[[4-(3-氧代-4- 吗咻基)苯基]氨基]丙基]1H-异吲哚 -1,3(2H)- 二酮); 利伐沙班N-3中间体; 4-[((2R)-羟基-3-邻苯二甲酰亚胺)丙胺]苯基-3-吗啉
• 英文别名: T56 BVNVJ C1YQ1MR D- AT6NV DOTJ &&R Form; 2-[(2R)-2-Hydroxy-3-[4-(3-oxo-mprpholinyl)phenyl]aminopropyl]-1H-isoindole-1,3-(2H)-dione; 2-[(2R)-2-HYDROXY-3-[[4-(3-OXO-4-MORPHOLINYL)PHENYL]AMINO]PROPYL]; 2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-morpholinyl)phenyl]amino]propyl]-1H-isoindole-1,3(2H)-dione; 2-[(2R)-2-hydroxy-3-[4-(3-oxomorpholin-4-yl)anilino]propyl]isoindole-1,3-dione; 4-[((2R)-Hydroxy-3-phthaliMido)propylaMine]phenyl-3-Morpholinone; Rivoxaban Impurity 50; Rivoxaban Phthalamide [oxazolidone ring opend] impurity; Rivoxaban Phthalimido Analog; 2-[(2R)-2-hydroxy-3-{[4-(3-oxoMorpholin-4-yl)phenyl]amino}p ropyl]-1H-isoindole-1,3(2H)-dione; 2-[(2R)-2-Hydroxy-3-{[4-(3-oxo-4-morpholinyl)phenyl]amino}propyl]-1H-isoindole-1,3(2H)-dione; TIANFUCHEM-446-5--1H-ISOINDOLE-1,3(2H)-DIONE, 2-[(2R)-2-HYDROXY-3-[[4-(3-OXO-4-MORPHOLINYL)PHENYL]AMINO]PROPYL]; 2-(2-Hydroxy-3-((4-(3-oxomorpholino); Rivoxaban Intermediates I; R –(2-Hydroxy-3-((4-(3-Oxo morpholino) Phenyl) Amino) Propyl) Isoindoline-1,3-dione; 2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]amino]propyl]-1H-isoindole-1; (R)-2-(2-Hydroxy-3-((4-(3-oxomorpholino)phenyl)amino)propyl)isoindoline-1,3-dione (Intermediate of Rivoxaban); C21H2IN3Os; 2-[(2R)-2-hydroxy-3-{[4-(3-oxomorpholin-4-yl)phenyl]amino}pr; 2-Amino-12-picoline; Intermediate of Rivoxaban 4; (R)-2-{2-Hydroxy-3-[4-(3-oxo-morpholin-4-yl)-phenylamino]-propyl}-isoindole-1,3-dione; 1H-ISOINDOLE-1,3(2H)-DIONE, 2-[(2R)-2-HYDROXY-3-[[4-(3-OXO-4-MORPHOLINYL)PHENYL]AMINO]PROPYL]; Rivoxaban interMediate B; Rivoxaban Phthalimido Descbonyl Impurity; 2-[(2R)-2-Hydroxy-3-{[4-(3-oxomorpholin-4-yl)phenyl]amino}propyl]-1H-isoindole-1,3(2H)-dione; H-ISOINDOLE-1,3(2H)-DIONE, 2-[(2R)-2-HYDROXY-3-[[4-(3-OXO-4-MORPHOLINYL)PHENYL]AMINO]PROPYL]; Rivoxaban Impurity 10/4-[((2R)-Hydroxy-3-phthalimido)propylamine]phenyl-3-morpholinone; (R)-2-(2-Hydroxy-3-((4-(3-oxomorpholino)phenyl)-amino)propyl)isoindoline-1,3-dione

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 734.9±60.0 °C at 760 mmHg
• 分子式: C₂₁H₂₁N₃O₅
• 分子量: 395.409
• 闪点: 398.3±32.9 °C
• 精确质量: 395.148132
• PSA: 99.18000
• LogP: 1.02
• 蒸汽压: 0.0±2.5 mmHg at 25°C
• 折射率: 1.672
• 储存条件: 室温

合成路线

161596-47-0 438056-69-0 ~93% 446292-07-5

文献：Roehrig, Susanne; Straub, Alexander; Pohlmann, Jens; Lampe, Thomas; Pernerstorfer, Josef; Schlemmer, Karl-Heinz; Reinemer, Peter; Perzborn, Elisabeth Journal of Medicinal Chemistry, 2005 , vol. 48, # 19 p. 5900 - 5908

1252018-10-2 1074-82-4 ~93% 446292-07-5

文献：APOTEX PHARMACHEM INC.; BODHURI, Prabhudas; WEERATUNGA, Gamini Patent: WO2012/51692 A1, 2012 ; Location in patent: Page/Page column 42-43 ;

5455-98-1 438056-69-0 ~% 446292-07-5

文献：BAYER HEALTHCARE AG Patent: US2010/160301 A1, 2010 ; US 20100160301 A1

136918-14-4 1252018-10-2 ~% 446292-07-5

文献：SYMED LABS LIMITED; MOHAN RAO, dodda; KRISHNA REDDY, pingili; ANNA REDDY, ambati; VENKAT REDDY, buthukuri Patent: WO2012/32533 A2, 2012 ; Location in patent: Page/Page column 16 ;

122-98-5 ~% 446292-07-5

文献：CADILA HEALTHCARE LIMITED; DWIVEDI, Shriprakash, Dhar; PRASAD, Ashok; PAL, Daya, Ram; SHARMA, Mukul, Hari, Prasad; JAIN, Kuldeep, Natwarlal; PATEL, Naitik, Bharatbhai Patent: WO2013/98833 A2, 2013 ;

446292-04-2 ~% 446292-07-5

文献：CADILA HEALTHCARE LIMITED; DWIVEDI, Shriprakash, Dhar; PRASAD, Ashok; PAL, Daya, Ram; SHARMA, Mukul, Hari, Prasad; JAIN, Kuldeep, Natwarlal; PATEL, Naitik, Bharatbhai Patent: WO2013/98833 A2, 2013 ;

29518-11-4 ~% 446292-07-5

文献：CADILA HEALTHCARE LIMITED; DWIVEDI, Shriprakash, Dhar; PRASAD, Ashok; PAL, Daya, Ram; SHARMA, Mukul, Hari, Prasad; JAIN, Kuldeep, Natwarlal; PATEL, Naitik, Bharatbhai Patent: WO2013/98833 A2, 2013 ;

136918-14-4 ~% 446292-07-5

文献：FARMAK, A.S.; URBASEK, Miroslav; HRADIL, Pavel; GREPL, Martin; FIALOVA, Petra; OREMUS, Vladimir; SLEZAR, Petr Patent: WO2012/41263 A2, 2012 ;

438056-69-0 ~% 446292-07-5

文献：APOTEX PHARMACHEM INC.; BODHURI, Prabhudas; WEERATUNGA, Gamini Patent: WO2012/51692 A1, 2012 ;

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