1088434-86-9

• 常用中文名：ACS67
• 常用英文名：ACS67
• CAS号：1088434-86-9
• 分子式：C₃₂H₃₈O₅S₃
• 分子量：598.836
• 发布时间：2016-07-04 09:12:41
• 更新时间：2024-01-03 12:11:15
• ACS67 is an F-series prostaglandin (PG) analog for treatment of glaucoma. ACS 67 reduces intra-ocular pressure (IOP) and increases levels of reduced glutathione and cGMP in the aqueous humor of glaucomatous pigmented rabbits. ACS67 also acts as a neuroprotectant that stimulates GSH levels.

名称

• 英文名: acs 67
• 英文别名: 4-(3-Thioxo-3H-1,2-dithiol-5-yl)phenyl (5Z)-7-[3,5-dihydroxy-2-(3-hydroxy-5-phenylpentyl)cyclopentyl]-5-heptenoate; 5-Heptenoic acid, 7-[3,5-dihydroxy-2-(3-hydroxy-5-phenylpentyl)cyclopentyl]-, 4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl ester, (5Z)-; 5-p-nitrobenzylidene-2-thiohydantoin

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 777.4±70.0 °C at 760 mmHg
• 分子式: C₃₂H₃₈O₅S₃
• 分子量: 598.836
• 闪点: 424.0±35.7 °C
• 精确质量: 598.188110
• PSA: 175.56000
• LogP: 5.48
• 蒸汽压: 0.0±2.8 mmHg at 25°C
• 折射率: 1.668

合成路线

18274-81-2 41639-83-2 ~65% 1088434-86-9

文献：Perrino, Elena; Uliva, Caterina; Lanzi, Cecilia; Soldato, Piero Del; Masini, Emanuela; Sparatore, Anna Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 6 p. 1639 - 1642

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