69353-21-5

• 常用中文名：氢溴酸加兰他敏
• 常用英文名：5-METHOXY-9-METHYL-2,3,3A,3A1,8,9,10,11-OCTAHYDRO-4-OXA-9-AZACYCLOOCTA[DEF]FLUOREN-2-OL HYDROBROMIDE
• CAS号：69353-21-5
• 分子式：C₁₇H₂₂BrNO₃
• 分子量：368.3
• 相关类别： 原料药 神经系统用药 拟胆碱药
• 发布时间：2018-09-17 16:54:07
• 更新时间：2026-07-02 22:01:10

名称

• 中文名: 氢溴酸加兰他敏
• 英文名: galanthamine hydrobromide
• 中文别名: 加兰他敏溴化氢盐; 八氢-5-甲氧基-9-甲基苯并呋喃[4,3,2-EFG]苯并氮杂环辛烷-2-醇氢溴酸盐; Galant胺氢溴酸; 加兰他敏HBR; 左旋加兰他敏; 八氢-5-甲氧基-9-甲基苯并呋喃[4,3,2-EFG]苯并氮杂环辛烷-2-醇氢溴酸盐(氢溴酸加兰他敏); 氢溴酸伽兰他敏; 2,3,3A,8,9,10,11,11B-八氢-5-甲氧基-9-甲基苯并呋喃[4,3,2-EFG]苯并氮杂环辛烷-2-醇氢溴酸盐
• 英文别名: NIVALIN, HBR; lycoreminehydrobromide; 2-benzylhexahydro-1H-isoindol-4(2H)-one; (3aS)-4c-methoxy-3,8c-diphenyl-(3ar,5ac,9at,9bc)-hexahydro-[1,3]dioxino[4',5':5,6]pyrano[3,4-d]oxazole-2-thione; Galanthamine, Hydrobromide - - Calbiochem; 5-Methoxy-9-methyl-2,3,3a,3a1,8,9,10,11-octahydro-4-oxa-9-azacycloocta[def]fluoren-2-ol hydrobromide; (3ARS,7ASR)-2-benzyl-4-perhydroisoindolone; Galantamine HydrobromideQ: What is Galantamine Hydrobromide Q: What is the CAS Number of Galantamine Hydrobromide Q: What is the storage condition of Galantamine Hydrobromide; GALANTHAMINE HBR; 1,2,3,4,6,7,7a,11c-Octahydro-9-methoxy-2-methylbenzofuro[4,3,2-efg]-2-benzazocin-6-ol hydrobromide; (3aS)-2-methoxy-(3arC4,14bc)-1,5,6,8,9,14b-hexahydro-4H-cyclopenta[b][1,3]dioxolo[4',5':4,5]benzo[1,2-d]pyrrolo[1,2-a]azepine-1t,9t-diol; 2,3,3a,8,9,10,11,11b-Octahydro-5-methoxy-9-methylbenzofuro[4,3,2-efg][2]benzazocin-2-ol hydrobromide; GALANTHAMIDE HYDROBROMIDE; nivaline; (3aS)-1-benzyl-3a-methyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-ol; nivaline(phmaceutical); 1990/4/4; Galanthamine HBr (Galantamine Hydrobromide); GALANTHAMINE HYDROBROMIDE; Galantamine synthetic for system suitability; Benzofuro[4,3,2-efg]benzazocin-2-ol,2,3,3a,8,9,10,11,11b-octahydro-5-Methoxy-9-Methyl-, hydrobroMide (9CI); NIVALIN; High purity GALANTHAMINE HYDROBROMIDE in stock; 4A,5,9,10,11,12-HEXAHYDRO-3-METHOXY-11-METHYL-6H-BENZOFURO[3A,3,2-EF]BENZAZIN-6-OL HYDROBROMIDE; 3,2-efg)benzazocin-6-ol,1,2,3,4,6,7,7a,11c-octahydro-9-methoxy-benzofuro(; Galantamine natural for system suitability; (3aS)-1-benzyl-5-ethoxy-3a,8-dimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole; (3aS)-1-benzyl-5-ethoxy-3a,8-d methyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole; zocin-6-olhbr; 5-Methoxy-9-methyl-2,3,3a,3a1,8,9,10,11-octahydro-4-oxa-9-azacycloocta[def]fluoren-2-ol hydrobromide(Galantamine Hydrobromide); Galantamine O-D3 HBr; (3aS)-1-benzyl-3a-methyl-1,2,3,3a,8,8a-tetrahydropyrrolo[2,3-b]indole-5-ol; Galantamine N-D3 HBr; 11-hydroxycephalotaxine; nivaline(c17phmaceutical); galanthaminehydrogenbromide; 11-Hydroxycephalotaxin; (3aS)-4c-Methoxy-3,8c-diphenyl-(3ar,5ac,9at,9bc)-hexahydro-[1,3]dioxino[4',5':5,6]pyrano[3,4-d]oxazol-2-thion; Nootropics Power Galanthamine; GALANTHAMINE HYDROBROMIDE //BP; 2,3,3a,8,9,10,11,11b-Octahydro-5-methoxy-9-methylbenzofuro[4,3,2-efg]benzazocin-2-ol hydrobromide; 1,2,3,4,6,7,7a,11c-octahydro-9-methoxy-2-methyl-benzofuro(4,3,2-efg)benza; jilkonhydrobromide; GALANTAMINE HBR

物化性质

• 密度: 1.593 g/cm3
• 沸点: 630.4ºC at 760 mmHg
• 熔点: 287ºC decomposes
• 分子式: C₁₇H₂₂BrNO₃
• 分子量: 368.3
• 闪点: 335ºC
• 精确质量: 367.07831
• PSA: 18.46000
• LogP: 3.58460
• 储存条件: −20°C

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : DF8075000 CHEMICAL NAME : Benzofuro(4,3,2-efg)(2)benzazocin-6-ol, 1,2,3,4,6,7,7a,11c-octahydro-9-methoxy-2-methyl-, hydrobromide CAS REGISTRY NUMBER : 69353-21-5 LAST UPDATED : 199212 DATA ITEMS CITED : 7 MOLECULAR FORMULA : C17-H21-N-O3.Br-H MOLECULAR WEIGHT : 368.31 WISWESSER LINE NOTATION : T766 C6/CM B 2AC Q CX EN LO PUT&TTJ E1 JO1 OQ &EH HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 75 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PHMGBN Pharmacology: International Journal of Experimental and Clinical Pharmacology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1- 1968- Volume(issue)/page/year: 32,301,1986 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 10 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PHMGBN Pharmacology: International Journal of Experimental and Clinical Pharmacology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1- 1968- Volume(issue)/page/year: 32,301,1986 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 18700 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CHABA8 Chemical Abstracts. (Chemical Abstracts Service, Box 3012, Columbus, OH 43210) V.1- 1907- Volume(issue)/page/year: 66,53993v,1967 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 9 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : ABMGAJ Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.) V.1-41, 1958-82. For publisher information, see BBIADT. Volume(issue)/page/year: 7,402,1961 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 15400 ug/kg TOXIC EFFECTS : Peripheral Nerve and Sensation - fasciculations Behavioral - tremor Lungs, Thorax, or Respiration - dyspnea REFERENCE : FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 25,168,1962 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 5200 ug/kg TOXIC EFFECTS : Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - excitement Gastrointestinal - changes in structure or function of salivary glands REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 3,347,1961 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 0.05 mg/m3;Skin JAN 1993

安全

• 危害码 (欧洲): T: Toxic;
• 风险声明 (欧洲): R25
• 安全声明 (欧洲): S45
• 危险品运输编码: UN 2811 6.1/PG 3
• WGK德国: 3
• RTECS号: DF8075000
• 包装等级: III
• 危险类别: 6.1(b)
• 海关编码: 2942000000

海关

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%