74578-38-4

• 常用中文名：1-UFT protocol
• 常用英文名：1-UFT protocol
• CAS号：74578-38-4
• 分子式：C₁₂H₁₃FN₄O₅
• 分子量：312.25
• 相关类别： 研究领域 癌症
• 发布时间：2016-06-09 11:52:26
• 更新时间：2024-02-27 08:42:15
• 替加氟尿嘧啶是一种口服活性氟嘧啶类抗癌药物。替加氟尿嘧啶抑制胸苷酸合成酶。替加氟尿嘧啶可用于研究抗实体瘤[1]。

名称

• 英文名: 5-fluoro-1-(oxolan-2-yl)pyrimidine-2,4-dione,1H-pyrimidine-2,4-dione
• 英文别名: FT mixt. with uracil (1:4); Uracil-Tegafur; Youfuding; Tegafur-uracil mixture; Uracil mixt. with FT (4:1); Uracil mixt. with tegafur (4:1); Ufur; UFT; Tegafur mixt. with uracil (1:4)

物化性质

• 沸点: 467.1ºC at 760 mmHg
• 分子式: C₁₂H₁₃FN₄O₅
• 分子量: 312.25
• 闪点: 236.3ºC
• 精确质量: 312.08700
• PSA: 130.59000
• LogP: 0.28480

生物活性

• 描述: 替加氟尿嘧啶是一种口服活性氟嘧啶类抗癌药物。替加氟尿嘧啶抑制胸苷酸合成酶。替加氟尿嘧啶可用于研究抗实体瘤[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Casado E, et al. UFT (tegafur-uracil) in rectal cancer. Ann Oncol. 2008;19(8):1371-1378.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : YR0480000 CAS REGISTRY NUMBER : 74578-38-4 LAST UPDATED : 198910 DATA ITEMS CITED : 8 MOLECULAR FORMULA : C8-H9-F-N2-O3.4C4-H4-N2-O2 MOLECULAR WEIGHT : 648.59 WISWESSER LINE NOTATION : T6NVMVJ EF A- BT5OTJ &T6MVMVJ 4 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1580 mg/kg TOXIC EFFECTS : Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - dyspnea Blood - other changes REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 20,1009,1980 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1275 mg/kg TOXIC EFFECTS : Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - dyspnea Blood - other changes REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 20,1009,1980 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 150 mg/kg TOXIC EFFECTS : Behavioral - tremor Vascular - other changes Gastrointestinal - nausea or vomiting REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 20,1009,1980 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 242 mg/kg TOXIC EFFECTS : Vascular - other changes REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 20,1009,1980 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 713 mg/kg SEX/DURATION : female 7-17 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 22,85,1981 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 891 mg/kg SEX/DURATION : female 7-17 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 22,85,1981 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 2503 mg/kg SEX/DURATION : female 7-22 day(s) after conception lactating female 21 day(s) post-birth TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - blood and lymphatic systems (including spleen and marrow) REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 22,109,1981 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 875 mg/kg SEX/DURATION : female 7-22 day(s) after conception lactating female 21 day(s) post-birth TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - urogenital system REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 22,109,1981