13860-66-7

• 常用中文名：N3PT
• 常用英文名：N3PT
• CAS号：13860-66-7
• 分子式：C₁₃H₁₉Cl₂N₃OS
• 分子量：336.28000
• 相关类别： 研究领域 癌症
• 发布时间：2017-07-10 23:05:25
• 更新时间：2026-10-16 18:09:23
• N3PT(N3-pyridyl thiamine)是转酮醇酶（TK）抑制剂，对Apo-TK的IC50为22 nM。

名称

• 中文名: N3PT
• 英文名: 3-[(2-Amino-6-methyl-3-pyridinyl)methyl]-5-(2-hydroxyethyl)-4-met hyl-1,3-thiazol-3-ium chloride hydrochloride (1:1:1)
• 中文别名: N3PT,转酮醇酶(TKT)抑制剂; 转酮醇酶(TK)抑制剂(N3PT); 3-[(2-氨基-6-甲基-3-吡啶基)甲基]-5-(2-羟基乙基)-4-甲基噻唑氯化物盐酸盐; 3-((2-氨基-6-甲基吡啶-3-基)甲基)-5-(2-羟基乙基)-4-甲基-3-鎓氯盐酸盐
• 英文别名: 3-[(2-Amino-6-methyl-3-pyridyl)methyl]-5-(2-hydroxyethyl)-4-methylthiazolium chloride hydrochloride; 2-(1(2)H-pyrazol-3-yl)-5-trifluoromethyl-aniline; N3PT,N-3PT; 3-(2-Amino-6-methyl-[3]pyridylmethyl)-5-(2-hydroxy-aethyl)-4-methyl-thiazolium,Chlorid-hydrochlorid; 3-(2-amino-6-methyl-pyridin-3-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-thiazol-3-ium chloride hydrochloride; 2-(2H-pyrazol-3-yl)-5-(trifluoromethyl)aniline; 3-(2-amino-6-methyl-[3]pyridylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-thiazolium,chloride-hydrochloride; 3-(2-Amino-4-trifluormethylphenyl)pyrazol; 3-(2-amino-6-methyl-pyridin-3-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-thiazolium,chloride hydrochloride; N3-pyridyl thiaMine; 3-((2-Amino-6-methylpyridin-3-yl)methyl)-5-(2-hydroxyethyl)-4-methylthiazol-3-ium chloride hydrochloride

物化性质

• 分子式: C₁₃H₁₉Cl₂N₃OS
• 分子量: 336.28000
• 精确质量: 335.06300
• PSA: 91.26000
• 储存条件: 2-8℃

生物活性

• 描述: N3PT(N3-pyridyl thiamine)是转酮醇酶(TK)抑制剂,对Apo-TK的IC50为22 nM。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 癌症
• 参考文献:

  [1]. Allen A. Thomas, Josh Ballard, Bryan Bernat. Potent and Selective Thiamine Antagonists That Inhibit Transketolase.

  [2]. Jeno Gyuris, May Han, Ronan C, N3-pyridyl-thiamine and its use in cancer treatments. Patent Numeber: WO2005094803 A2

  [3]. Thomas AA, De Meese J, Le Huerou Y, Non-charged thiamine analogs as inhibitors of enzyme transketolase. Bioorg Med Chem Lett. 2008 Jan 15;18(2):509-12.

合成路线

13051-49-5 ~% 13860-66-7

文献：Matsukawa; Matsuno Yakugaku Zasshi, 1944 , vol. 64, # 3 p. 145,150 Chem.Abstr., 1951 , p. 4724

856956-20-2 ~% 13860-66-7

文献：Dornow; Hargesheimer Chemische Berichte, 1953 , vol. 86, p. 461,464

70959-85-2 ~% 13860-66-7

文献：Dornow; Hargesheimer Chemische Berichte, 1953 , vol. 86, p. 461,464

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