612069-27-9

• 常用中文名：N',N'-二(去甲基)阿奇霉素
• 常用英文名：3'-N,N-Di(desmethyl) Azithromycin
• CAS号：612069-27-9
• 分子式：C₃₆H₆₈N₂O₁₂
• 分子量：720.931
• 发布时间：2018-08-11 15:28:51
• 更新时间：2025-09-13 11:15:07

名称

• 中文名: 阿奇霉素杂质 E
• 英文名: 3'-N,N-Di(desmethyl) Azithromycin
• 中文别名: 3'、3'-N、N-去甲基阿奇霉素; 氨基阿奇霉素; (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11 - (((3R,4S,6R)-4-氨基-3-羟基-6-甲基四氢-2H-吡喃 2-基)氧基)-2-乙基-3,4,10-三羟基-13-((((2R,4R,5S,6S)-5-羟基-4-甲氧基-4,6-二甲基四氢-2H-吡喃 -2-基)氧基)-3,5,6,8,10,12,14-七甲基-1-氧杂-6-氮杂环十五烷-15-酮(阿奇霉素杂质); 阿奇霉素杂质E; 3'-N,N-二(去甲基)阿奇霉素; 阿奇霉素杂质5(阿奇霉素杂质E); N',N'-双(去甲基)阿奇霉素
• 英文别名: (Aminoazithromycin) (25 mg); (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-[(3-Amino-3,4,6-trideoxy-β-D-xylo-hexopyranosyl)oxy]-13-[(2,6-dideoxy-3-C-Methyl-3-O-Methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-htaMethyl-1-oxa; 3’-N,N-Di(desmethyl) Azithromycin; (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-(((2S,3R,4S,6R)-4-amino-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2-ethyl-3,4,10-trihydroxy-13-(((2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-3,5,6,8,10,12,14-htamethyl-1-oxa-6-azacyclopentadecan-15-one; (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-(((2S,3R,4S,6R)-4- amino-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2-ethyl-3,4, 10-trihydroxy-13-(((2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6- dimethyltetrahyd; Azithromycin Impurity EQ: What is Azithromycin Impurity E Q: What is the CAS Number of Azithromycin Impurity E Q: What is the storage condition of Azithromycin Impurity E Q: What e the applications of Azithromycin Impurity E; (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-[(3-Amino-3,4,6-trideoxy-β-D-xylo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-15-oxo-1-oxa-6-azacyclopentadecan-13-yl 2,6-dideo xy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranoside; (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-(((3R,4S,6R)-4-amino-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2-ethyl-3,4,10-trihydroxy-13-(((2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-3,5,6,8,10,12,14-htamethyl-1-oxa-6-az; 3'-N,N-Di(desMethyl) AzithroMycin; Azithromycin Impurity 5（Azithromycin Impurity E）; Azithromycin impurity E, EvoPure; Azithromycin di desmethyl impurity; (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-[(2S,3R,4S,6R)-4-amino-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,6,8,10,12,14-heptamethyl-1-oxa-6-azacyclopentadecan-15-one; Azithromycin Impurity E/(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-(((2S,3R,4S,6R)-4-amino-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2-ethyl-3,4,10-trihydroxy-13-(((2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-3,5,6,8,1; 3'-N,N-Di(desmethyl) Azithromycin(Azithromycin Impurity E); Azithromycin Impurity E (Amino Azithromycin/ 3′-(N,N-Didemethyl)azithromycin); N',N'-Di(desmethyl) Azithromycin; 1-Oxa-6-azacyclopentadecan-15-one, 11-[(3-amino-3,4,6-trideoxy-β-D-xylo-hexopyranosyl)oxy]-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-htamethyl-, (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R); Azithromycin Imp E; (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-(((2S,3S,4S,6R)-4-amino-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2-ethyl-3,4,10-trihydroxy-13-(((2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-3,5,6,8,10,12,14-htamethyl-1-oxa-6-azacyclopentadecan-15-one; Azithromycin Impurity 5; (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-(((2S,3S,4S,6R)-4-amino-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2-ethyl-3,4,10-trihydroxy-13-(((2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-3,5,6,8,10,12,14-htamethyl-1-oxa-6; Azithromycin mpurity E; 3′-(N,N-Didemethyl)Azithromycin, (Aminoazithromycin); 3a€-N,N-Di(desmethyl) Azithromycin; 3′-(N,N-Didemethyl)azithromycin; Amino Azithromycin

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 817.3±65.0 °C at 760 mmHg
• 分子式: C₃₆H₆₈N₂O₁₂
• 分子量: 720.931
• 闪点: 448.1±34.3 °C
• 精确质量: 720.477234
• PSA: 202.86000
• LogP: 2.62
• 蒸汽压: 0.0±0.6 mmHg at 25°C
• 折射率: 1.542

合成路线

172617-84-4 ~80% 612069-27-9

文献：Jakopovic, Ivana Palej; Krajacic, Mirjana Bukvic; Skugor, Maja Matanovic; Stimac, Vlado; Pesic, Dijana; Vujasinovic, Ines; Alihodzic, Sulejman; Paljetak, Hana Cipcic; Kragol, Goran Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 10 p. 3527 - 3530

83905-01-5 ~% 612069-27-9

文献：Jakopovic, Ivana Palej; Krajacic, Mirjana Bukvic; Skugor, Maja Matanovic; Stimac, Vlado; Pesic, Dijana; Vujasinovic, Ines; Alihodzic, Sulejman; Paljetak, Hana Cipcic; Kragol, Goran Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 10 p. 3527 - 3530

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