331741-94-7

331741-94-7结构式

常用中文名：莫格列地
常用英文名：Pargluva
CAS号：331741-94-7
分子式：C₂₉H₂₈N₂O₇
分子量：516.54200
相关类别：信号通路细胞周期/DNA损伤 PPAR
发布时间：2018-06-25 11:23:32
更新时间：2026-07-02 03:07:10
Muraglitazar是一种PPARα/γ双激动剂,用于治疗2型糖尿病和相关血脂异常。Muraglitazar在体外对人PPARα(EC50=320 nM)和PPARγ(EC50=110 nM)显示出强大的活性[1]。

中文名	莫格列地
英文名	Muraglitazar
中文别名	莫格他唑Muraglitaz N-((4-甲氧基苯氧基)羰基)-N-(4-(2-(5-甲基-2-苯基恶唑-4-基)乙氧基)苄基)甘氨酸莫格他唑甲醇中莫格他唑
英文别名	Muraglitaz symlinDiabetes Associated Ptide , amide Pgluva N-[(4-Methoxyphenoxy)carbonyl]-N-[[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]glycine 2-[(4-methoxyphenoxy)carbonyl-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-y l)ethoxy]phenyl]methyl]amino]acetic acid Glycine, N-[(4-methoxyphenoxy)carbonyl]-N-[[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl] amylin phmaceuticals muraglitaz(BMS-298585) N-((4-Methoxyphenoxy)carbonyl)-N-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benzyl)glycine 2-(((4-Methoxyphenoxy)carbonyl)(4-(2-(5-Methyl-2-phenyloxazol-4-yl)ethoxy)benzyl)amino)acetic acid 2-[(4-methoxyphenoxy)carbonyl-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]amino]acetic acid AMYLIN , AMIDE; AMYLIN PHMACEUTICALS; MURAGLITAZ; OXYNTOMODULIN; SYMLINDIABETES ASSOCIATED PTIDE , AMIDE Amylin , amide

描述	Muraglitazar是一种PPARα/γ双激动剂,用于治疗2型糖尿病和相关血脂异常。Muraglitazar在体外对人PPARα(EC50=320 nM)和PPARγ(EC50=110 nM)显示出强大的活性[1]。
相关类别	信号通路 >> 细胞周期/DNA损伤 >> PPAR 研究领域 >> 代谢疾病
参考文献	[1]. Buse JB, Rubin CJ, Frederich R, et al. Muraglitazar, a dual (alpha/gamma) PPAR activator: a randomized, double-blind, placebo-controlled, 24-week monotherapy trial in adult patients with type 2 diabetes. Clin Ther. 2005;27(8):1181-1195. [2]. Cox SL. Muraglitazar: an agent for the treatment of type 2 diabetes and associated dyslipidemia. Drugs Today (Barc). 2005;41(9):579-587.