603-41-8

• 常用中文名：4,4’-(2-吡啶甲基)双酚
• 常用英文名：Desacetyl Bisacodyl
• CAS号：603-41-8
• 分子式：C₁₈H₁₅NO₂
• 分子量：277.32
• 相关类别： 研究领域 代谢疾病
• 发布时间：2018-04-26 08:00:00
• 更新时间：2026-07-11 09:21:54
• Desacetyl bisacodyl 是泻药比沙可啶的活性代谢物。Desacetyl bisacodyl 诱导大鼠结肠和直肠上皮 Cl(-) 分泌。Desacetyl bisacodyl 会对结肠或直肠产生多种影响,包括增加粘液和氯化物分泌。

名称

• 中文名: 4,4’-(2-吡啶甲基)双酚
• 英文名: 4-[(4-hydroxyphenyl)-pyridin-2-ylmethyl]phenol
• 中文别名: 苉可硫酸钠杂质B; 匹可硫酸纳杂质B; 匹克硫酸钠杂质; 匹可硫酸钠杂质B对照品; 比沙可啶杂质A/匹可硫酸钠杂质B 标准品; 4,4' - (吡啶-2-基甲基)苯酚; 比沙可啶杂质A(吡啶磺酸钠杂质B); 比沙可啶杂质A(匹可硫酸钠杂质B); 匹可硫酸杂质B; 比沙可啶相关化合物A; 4,4'-(2-吡啶甲基)双酚; 4,4'-(吡啶-2-基亚甲基)二苯酚; 匹可磷酸杂质B; 化合物:Desacetyl Bisacodyl; 比沙可啶中间体; 4,4'-二羟苯基-(2-吡啶)甲烷; 双醋苯啶相关物质A 标准品; 脱乙酰比沙可啶检测标准品; 去乙酰基比沙可啶; 4,4'-(2-吡啶亚甲基)双-苯酚; 去二乙酰比沙可啶; 苉可钠杂质B; 吡啶磺酸钠杂质B; 比沙可啶杂质1(比沙可啶杂质A); 匹克硫酸钠杂质2(匹克硫酸钠杂质B); 化合物：Desacetyl Bisacodyl; 比沙可啶杂质A; 甲醇中脱乙酰比沙可啶标准溶液; 匹可硫酸钠杂质B; 脱乙酰比沙可啶; 匹可硫酸钠杂质B(比沙可啶杂质A); 脱乙酰基比沙可啶; 比沙可啶相关物质A
• 英文别名: Deacetylbisocodyl; dihydroxydiphenyl-pyridyl methane; BISACODYL RC A; 4,4'-Dihydroxydiphenyl(2-pyridyl)methane; 4,4'-(2-Pyridylmethylene)bisphenol; p,p'-(2-pyridylmethylene)bisphenol; Bisacodyl Related Compound A (4,4''-(Pyridin-2-ylmethylene)diphenol); 4,4'-(pyridin-2-ylmethylene)diphenol; Picosulfate IMpurity B; Bisacodyl Impurity A/ Bisacodyl Related Compound A; Phenol, 4,4'-(2-pyridinylmethylene)bis; Desdiacetyl BisacodylQ: What is Desdiacetyl Bisacodyl Q: What is the CAS Number of Desdiacetyl Bisacodyl Q: What e the applications of Desdiacetyl Bisacodyl; Sodium Picosulfate Impurity B (Bisacodyl Impurity A); La-96; Sodium Picosulfate Impurity; 4-[(4-hydroxyphenyl)-pyridin-2-yl-methyl]phenol; La 96; (4,4'-Dihydroxy diphenyl)-pyridyl-2-methane; Bis(4-hydroxyphenyl)(2-pyridyl)methane; 4,4'-(2-pyridylmethyl)bisphenol; Sodium Picosulfate Impurity B (Bisacodyl Impurity A, Bisacodyl Related Compound A); Desdiacetyl Bisacodyl; Bisacodyl Related Compound A (20 mg) (4,4'-(Pyridin-2-ylmethylene)diphenol); Dihydroxydiphenyl-pyridyl methane; 4-[(4-hydroxyphenyl)-(2-pyridyl)methyl]phenol; Bisacodyl Related Compound A (4,4'-(Pyridin-2-ylmethylene)diphenol); DDPM (phmaceutical); Picosulfate Impurity 2（Picosulfate Impurity B）; DDPM; Desacetyl Bisacodyl5; Bisacodyl Impurity 1 (Bisacodyl Impurity A); Bisacodyl Related Compound A; deacetylbisacodyl; Bisacodyl Impurity A; Bis(4-hydroxyphenyl) (2-pyridyl) methane / Deacetyl Bisacodyl; EINECS 210-039-7; Sodium Picosulfate Impurity B; 4,4''-(2-PYRIDINYLMETHYLENE)BISPHENOL; Bisacodyl Impurity A（Sodium Picosulfate Impurity B）; 4,4'-pyridin-2-ylmethanediyl-bis-phenol; 4,4'-(Pyridin-2-ylmethylene)dipheno

物化性质

• 密度: 1.244g/cm3
• 沸点: 462.1ºC at 760 mmHg
• 熔点: >200ºC (dec.)
• 分子式: C₁₈H₁₅NO₂
• 分子量: 277.32
• 闪点: 233.3ºC
• 精确质量: 277.11000
• PSA: 53.35000
• LogP: 3.67300
• 折射率: 1.655
• 储存条件: -20°C，密闭，干燥

生物活性

• 描述: Desacetyl bisacodyl 是泻药比沙可啶的活性代谢物。Desacetyl bisacodyl 诱导大鼠结肠和直肠上皮 Cl(-) 分泌。Desacetyl bisacodyl 会对结肠或直肠产生多种影响,包括增加粘液和氯化物分泌。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Fujita T, et, al. Desacetyl bisacodyl-induced epithelial Cl(-) secretion in rat colon and rectum. Biomed Res. 2016;37(1):13-20.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : SM8730000 CHEMICAL NAME : Phenol, 4,4'-(2-pyridylmethylene)di- CAS REGISTRY NUMBER : 603-41-8 BEILSTEIN REFERENCE NO. : 0212040 LAST UPDATED : 199612 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C18-H15-N-O2 MOLECULAR WEIGHT : 277.34 WISWESSER LINE NOTATION : T6NJ BYR DQ&R DQ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 8550 mg/kg TOXIC EFFECTS : Behavioral - food intake (animal) Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : NAIZAM Nara Igaku Zasshi. Journal of the Nara Medical Association. (Nara Igakkai, c/o Narakenritsu Ika Daigaku, Shijo-cho, Kashihara, Nara-ken, Japan) V.1- 1950- Volume(issue)/page/year: 28,258,1977

安全

• 危险品运输编码: NONH for all modes of transport

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