14487-05-9

• 常用中文名：利福霉素-O
• 常用英文名：Rifamycin O
• CAS号：14487-05-9
• 分子式：C₃₉H₄₇NO₁₄
• 分子量：767.815
• 相关类别： 原料药 抗生素类药物 利福霉素类药
• 发布时间：2018-07-27 16:10:35
• 更新时间：2026-08-02 23:07:34

名称

• 中文名: 二恶酮利福霉素
• 英文名: rifamycin O
• 中文别名: 利福霉素0; 利福霉素O; 螺[1,3-二氧戊环-2,9'(6'H)-[2,7](环氧十五碳环[1,11,13]三烯亚氨基)萘并[2,1-B]呋喃]-1',4,6',11'(2'H)-四酮, 5',17',19',21'-四羟基-23'-甲氧基-2',4',12',1; 利福昔明杂质F(利福霉素杂质C); 利福霉素, 4-O-(羧基甲基)-1-脱氧-1,4-二氢-4-羟基-1-氧代-, Γ-内酯 (9CI, ACI); 利福昔明杂质F; 利福霉素, 4-O-(羧基甲基)-1-脱氧-1,4-二氢-4-羟基-1-氧代-, γ-内酯 (9CI, ACI); 利福霉素杂质F; 利福昔明杂质F /BP); 螺[1,3-二氧戊环-2,9'(6'H)-[2,7](环氧十五碳环[1,11,13]三烯亚氨基)萘并[2,1-B]呋喃]-1',4,6',11'(2'H)-四酮, 5',17',19',21'-四羟基-23'-甲氧基-2',4',12',16',18',20',22'-七甲基-21'-乙酸酯; 利福昔明杂质6(利福昔明杂质F); 利福昔明杂质F(利福霉素O)
• 英文别名: 2,1-b)furan)-1’,4,6’,11’(2’h)-tetrone,5’,17’,19’,21’-tetrahydroxy-23’-methoxy; 4-o-(carboxymethyl)-1-deoxy-1,4-dihydro-4-hydroxy-1-oxo-rifamycigamma-la; 4-O-(CBOXYMETHYL)-1-DEOXY-1,4-diHYDRO-4-HYDROXY-1-OXO-G-LACTONE; Rifomycin O; 4-o-(cboxymethyl)-1-deoxy-1,4-dihydro-4-hydroxy-1-oxo-rifamycigamma-la; Rifamycin, 4-O-(cboxymethyl)-1-deoxy-1,4-dihydro-4-hydroxy-1-oxo-, γ-lactone (9CI, ACI); (7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17-Trihydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23,29-trioxo-27-(4-oxo-1,3-dioxolan-2-yl)-8,30-dioxa-24-azatetracyclo[23.3.1.1.0]triaconta-1(28),2,4,9,19,21,25-heptaen-13-yl acetate; 4-O-(Carboxymethyl)-1-deoxy-1,4-dihydro-4-hydroxy-1-oxorifamycin g-lactone; Rifamycin Impurity 3(Rifamycin Impurity C)（Rifamycin O); Rifamycin O //BP; Spiro[1,3-dioxolane-2,9'(6'H)-[2,7]oxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan]-1',4,6',11'(2'H)-tetrone, 5',17',19',21'-tetrahydroxy-23'-methoxy-2',4',12',16',18',20',22'-htamethyl-21'-acetate; spiro(1,3-dioxolane-2,9’(6’h)-(2,7)oxypentadeca(1,11,13)trienimino)naphtho(; Rifamycin, 4-O-(cboxymethyl)-1-deoxy-1,4-dihydro-4-hydroxy-1-oxo-, γ-lactone; Levofloxacin O; Rifamycin, 4-O-(cboxymethyl)-1-deoxy-1,4-dihydro-4-hydroxy-1-oxo-, gamma-lactone; spiro[1,3-dioxolane-2,9'(6'H)-[2,7]oxy pentadecene azomethine)naphtho[2,1-b]furan]-1',4,6',11'(2'H)-tetraone, 5',17',19',21'-tetrahydroxy-23'-methoxy-2',4',12',16',18',20',22'-htamethyl-21'-acetate; rifamycin-O; Rifaximin Impurity F (Rifamycin O); Rifaximin Impurity F（Rifamycin Impurity C）; Rifaximin impurity F; RifaMycin,4-O-(cboxyMethyl)-1-deoxy-1,4-dihydro-4-hydroxy-1-oxo-, g-lactone; (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-5,17,19-trihydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,6,11-trioxo-9-(4-oxo-1,3-dioxolan-2-yl)-1,2,6,9-tetrahydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate; Rifamycin Impurity C; 4-O-Cboxymethyl-1-deoxy-1,4-dihydro-4-hydroxy-1-oxorifamycin γ-lactone; 4-O-(cboxymethyl)-1-deoxy-1,4-dihydro-4-hydroxy-1-oxo-Rifamycin γ-lactone (9CI ACI); 4’,12’,16’,18’,20’,22’-htamethyl-221’-acetate; ctone; Rifaximin Impurity 6 (Rifaximin Impurity F); 4-o-(Cboxymethyl)-1-deoxy-1,4-dihydro-4-hydroxy-1-oxo-rifamycin gamma-lactone; RIFAMYCIN O

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 972.8±65.0 °C at 760 mmHg
• 熔点: 171ºC (dec.)
• 分子式: C₃₉H₄₇NO₁₄
• 分子量: 767.815
• 闪点: 542.2±34.3 °C
• 精确质量: 767.315308
• PSA: 213.45000
• LogP: 1.38
• 外观性状: 黄色固体
• 蒸汽压: 0.0±0.3 mmHg at 25°C
• 折射率: 1.608
• 储存条件: -20°C

安全

• 危害码 (欧洲): Xi

合成路线

13929-35-6 ~77% 14487-05-9

文献：Bacchi, Alessia; Pelizzi, Giancarlo; Nebuloni, Marino; Ferrari, Pietro Journal of Medicinal Chemistry, 1998 , vol. 41, # 13 p. 2319 - 2332

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