487-53-6

• 常用中文名：羟普鲁卡因
• 常用英文名：Hydroxyprocaine
• CAS号：487-53-6
• 分子式：C₁₃H₂₀N₂O₃
• 分子量：252.30900
• 发布时间：2018-09-02 18:25:28
• 更新时间：2024-01-10 10:18:33

名称

• 中文名: 羟普鲁卡因
• 英文名: 2-(diethylamino)ethyl 4-amino-2-hydroxybenzoate
• 中文别名: 羟基普鲁卡因; 2-(二乙基氨基)乙基4-氨基-2-羟基苯甲酸酯
• 英文别名: 4-Amino-2-hydroxy-benzoesaeure-(2-diaethylamino-aethylester); Metahydroxyprocaine; Oxyprocain; Hydroxyprocaine; Oxycaine; Hydroxynovocain; 2-Diethylaminoethyl p-aminosalicylate; 4-Amino-salicylsaeure-(2-diethylamino-ethylester); Oxyprocaine; m-Hydroxyprocaine; Oxiprocainum; 4-Amino-2-hydroxy-benzoesaeure-(2-diethylamino-ethylester); p-Amino-salicylsaeure-diaethylaminoaethyl-ester; Hydroxy-procain; 4-amino-2-hydroxy-benzoic acid-(2-diethylamino-ethyl ester); Diethylaminoethyl p-aminosalicylate; MFCD00047845

物化性质

• 密度: 1.158g/cm3
• 沸点: 408.7ºC at 760mmHg
• 分子式: C₁₃H₂₀N₂O₃
• 分子量: 252.30900
• 闪点: 201ºC
• 精确质量: 252.14700
• PSA: 75.79000
• LogP: 2.05420
• 蒸汽压: 2.9E-07mmHg at 25°C
• 折射率: 1.565

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : VO1575000 CHEMICAL NAME : Salicylic acid, 4-amino-, 2-(diethylamino)ethyl ester CAS REGISTRY NUMBER : 487-53-6 BEILSTEIN REFERENCE NO. : 2650192 LAST UPDATED : 199612 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C13-H20-N2-O3 MOLECULAR WEIGHT : 252.35 WISWESSER LINE NOTATION : ZR CQ DVO2N2&2 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 190 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : KLWOAZ Klinische Wochenscrift. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.1- 1922- Volume(issue)/page/year: 31,97,1953 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 36 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : KLWOAZ Klinische Wochenscrift. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.1- 1922- Volume(issue)/page/year: 31,97,1953 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 125 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 2,112,1952 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 280 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : KLWOAZ Klinische Wochenscrift. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.1- 1922- Volume(issue)/page/year: 31,97,1953 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 47 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : KLWOAZ Klinische Wochenscrift. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.1- 1922- Volume(issue)/page/year: 31,97,1953 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 72 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 10,284,1951

安全

• 海关编码: 2922509090

合成路线

65-49-6 ~% 487-53-6

文献：Tanaka; Asami Journal of the Scientific Research Institute, Tokyo, 1954 , vol. 48, p. 287,293

16987-14-7 109-89-7 ~% 487-53-6

文献：Tanaka; Asami Journal of the Scientific Research Institute, Tokyo, 1954 , vol. 48, p. 287,293 Full Text Show Details Rheinpreussen A.G. Patent: DE954425 , 1956 ; Full Text Show Details Steinkohlen-Bergwerk Rheinpreussen Patent: DE842944 , 1951 ; DRP/DRBP Org.Chem.

65-49-6 100-35-6 ~% 487-53-6

文献：Chabrier et al. Bulletin de la Societe Chimique de France, 1956 , p. 1669 Full Text Show Details Giudicelli et al. Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1956 , vol. 243, p. 108

65-49-6 100-37-8 ~% 487-53-6

文献：Grimme; Schmitz Chemische Berichte, 1951 , vol. 84, p. 734,742 Full Text Show Details Steinkohlen-Bergwerk Rheinpreussen Patent: DE842944 , 1951 ; DRP/DRBP Org.Chem.

117869-04-2 100-37-8 ~% 487-53-6

文献：Rheinpreussen A.G. Patent: US2763678 , 1953 ; Full Text Show Details Rheinpreussen A.G. Patent: DE954425 , 1956 ;

408536-66-3 109-89-7 ~% 487-53-6

文献：Kakemi; Arita; Kitazawa; Sagawa Chemical and pharmaceutical bulletin, 1967 , vol. 15, # 12 p. 1828 - 1840

上下游产品

上游产品  7
65-49-6 16987-14-7 109-89-7 100-35-6
100-37-8 117869-04-2 408536-66-3
下游产品  1
150-77-6

海关

海关编码	2922509090
中文概述	2922509090. 其他氨基醇酚、氨基酸酚及其他含氧基氨基化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件：AB. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装
监管条件	A.入境货物通关单 B.出境货物通关单
检验检疫	R.进口食品卫生监督检验 S.出口食品卫生监督检验
Summary	2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%