100-37-8

100-37-8结构式

常用中文名：二乙氨基乙醇
常用英文名：2-(Diethylamino)ethanol
CAS号：100-37-8
分子式：C₆H₁₅NO
分子量：117.189
相关类别：生物化工氨基酸及其衍生物氨基醇类衍生物
发布时间：2018-04-09 08:00:00
更新时间：2024-01-03 12:24:11
【用途一】
用作医药中间体、软化剂、乳化剂、固化剂等
【用途二】
用于有机合成及制药工业，也用作酸性媒质乳化剂
【用途三】
该品是医药中间体。用于制取普鲁卡因盐酸盐、咳必清、咳美芬、胃复康、延通心等。也用作溶剂，脱除天然气，炼厂气中的酸性气体，如硫化氢及二氧化碳。也可以制取脂肪酸的衍生物，纤维柔软剂，防锈剂，乳化剂，聚氨酯泡沫塑料的硫化催化剂及组分等。
【用途四】
主要用于医药中间体，有机合成及天然气中酸性气体的脱除。

中文名	二乙氨基乙醇
英文名	2-diethylaminoethanol
中文别名	N,N-二乙基乙醇胺二乙基乙醇胺
英文别名	N,N-Diethylethanolamine Diethylaminoethanol 2-(Diethylamino)ethanol 2-Diethylaminoethanol EINECS 202-845-2 MFCD00002850 2-Hydroxytriethylamine Ethanol, 2-(diethylamino)-

密度	0.9±0.1 g/cm3
沸点	164.8±13.0 °C at 760 mmHg
熔点	-70 °C
分子式	C₆H₁₅NO
分子量	117.189
闪点	48.9±0.0 °C
精确质量	117.115364
PSA	23.47000
LogP	0.74
外观性状	透明至淡黄色液体
蒸汽密度	4.04 (vs air)
蒸汽压	0.7±0.7 mmHg at 25°C
折射率	1.443
储存条件	储存注意事项储存于阴凉、通风的库房。库温不宜超过37℃。远离火种、热源。保持容器密封。应与氧化剂、酸类、食用化学品分开存放，切忌混储。采用防爆型照明、通风设施。禁止使用易产生火花的机械设备和工具。储区应备有泄漏应急处理设备和合适的收容材料。
稳定性	1.化学性质：具有叔胺和醇的化学反应性。用过氧化氢、高锰酸钾等氧化时，生成乙醇、乙酸、乙酰氧肟酸、氨、乙二醛和草酸等。用四乙酸铅氧化时，生成二乙胺与乙二醇醛。用硫代硫酸钾室温氧化生成乙醛。并可形成盐酸盐C6H15NO·HCl（熔点135~136℃），苦味酸盐［C6H15NO·C6H3N3O7（熔点79℃）］。 2.稳定性稳定 3.禁配物强氧化剂、强酸 4.聚合危害不聚合
水溶解性	soluble
凝固点	-70℃
分子结构	1、摩尔折射率：35.10 2、摩尔体积（cm³/mol）：132.3 3、等张比容（90.2K）：313.2 4、表面张力（dyne/cm）：31.4 5、极化率：13.91
计算化学	1.疏水参数计算参考值（XlogP）:0.3 2.氢键供体数量:1 3.氢键受体数量:2 4.可旋转化学键数量:4 5.互变异构体数量:无 6.拓扑分子极性表面积23.5 7.重原子数量:8 8.表面电荷:0 9.复杂度:43.8 10.同位素原子数量:0 11.确定原子立构中心数量:0 12.不确定原子立构中心数量:0 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:1
更多	1.性状：无色吸湿性液体，有氨味。 2.熔点（℃）：-70 3.沸点（℃）：163 4.相对密度（水=1）：0.88 5.相对蒸气密度（空气=1）：4.03 6.饱和蒸气压（kPa）：2.8（20℃） 7.辛醇/水分配系数：0.31 8.闪点（℃）：52（CC）；60（OC） 9.引燃温度（℃）：320 10.爆炸上限（%）：11.7 11.爆炸下限（%）：6.7 12.溶解性：与水混溶，溶于乙醇、乙醚、苯、丙酮等多数有机溶剂。 13.折射率（20ºC）：1.4412 14.黏度（mPa·s,20ºC）：3.5 15.黏度（mPa·s,25ºC）：4.05 16.黏度（mPa·s,60ºC）：1.50 17.蒸气压（kPa,55ºC）：1.33 18.蒸气压（kPa,100ºC）：10.67 19.燃烧热（KJ/mol）：4198.1 20.生成热（KJ/mol）：309.8

Name:	N N-Diethylethanolamine P.A. Material Safety Data Sheet
Synonym:	2-Diethylaminoethanol, Beta-Diethylaminoethano
CAS:	100-37-8

Section 1 - Chemical Product MSDS Name:N N-Diethylethanolamine P.A. Material Safety Data Sheet
Synonym:2-Diethylaminoethanol, Beta-Diethylaminoethano

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
100-37-8	N,N-Diethylethanolamine	99.0	202-845-2

Hazard Symbols: XI
Risk Phrases: 10 36/37/38

Section 3 - HAZARDS IDENTIFICATION

EMERGENCY OVERVIEW
Flammable. Irritating to eyes, respiratory system and skin.Hygroscopic.
Potential Health Effects
Eye:
May cause eye irritation. May cause eye injury.
Skin:
May cause severe skin irritation. May be harmful if absorbed through the skin.
Ingestion:
May cause irritation of the digestive tract. May be harmful if swallowed.
Inhalation:
Vapors may cause dizziness or suffocation. May cause nausea and possible vomiting.
Chronic:
None

Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin:
Get medical aid immediately. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician:
Antidote: None reported.

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Vapors may form an explosive mixture with air.
Vapors can travel to a source of ignition and flash back. Use water spray to keep fire-exposed containers cool. Containers may explode in the heat of a fire. Flammable liquid and vapor. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas.
Extinguishing Media:
For small fires, use dry chemical, carbon dioxide, water spray or alcohol-resistant foam. Do NOT get water inside containers. For large fires, use water spray, fog or alcohol-resistant foam. Cool containers with flooding quantities of water until well after fire is out.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Avoid runoff into storm sewers and ditches which lead to waterways. Use water spray to disperse the gas/vapor. Remove all sources of ignition. Use a spark-proof tool.
Provide ventilation.

Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Use only in a well-ventilated area.
Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame.
Avoid ingestion and inhalation. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Storage:
Keep away from heat, sparks, and flame. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Flammables-area. Store protected from moisture.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Liquid
Appearance: clear yellow brown
Odor: unpleasant odor
pH: Not available.
Vapor Pressure: 1.9 mbar @ 20 C
Viscosity: 5mPa @ 20C
Boiling Point: 161 deg C @ 760.00mm Hg
Freezing/Melting Point: -70 deg C
Autoignition Temperature: 260 deg C ( 500.00 deg F)
Flash Point: 60 deg C ( 140.00 deg F)
Explosion Limits, lower: 6.70 vol %
Explosion Limits, upper: 11.7 vol %
Decomposition Temperature:
Solubility in water: soluble
Specific Gravity/Density: .8840g/cm3
Molecular Formula: C6H15NO
Molecular Weight: 117.19

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, ignition sources, excess heat, strong oxidants, exposure to moist air or water.
Incompatibilities with Other Materials:
Moisture.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen.
Hazardous Polymerization: Has not been reported.

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 100-37-8: KK5075000 LD50/LC50:
CAS# 100-37-8: Dermal, guinea pig: LD50 = 1 mL/kg; Draize test, rabbit, eye: 5 mg Severe; Inhalation, mouse: LC50 = 5000 mg/m3; Oral, rat: LD50 = 1300 mg/kg; Skin, rabbit: LD50 = 1260 uL/kg.
Carcinogenicity:
N,N-Diethylethanolamine - Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION
Ecotoxicity:
Fish: Fathead Minnow: 1780 mg/L; 96 Hr.; Flow-through

Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
Shipping Name: 2-DIETHYLAMINOETHANOL
Hazard Class: 8
UN Number: 2686
Packing Group: II
IMO
Shipping Name: DIETHYLAMINOETHANOL
Hazard Class: 3.3
UN Number: 2686
Packing Group: III
RID/ADR
Shipping Name: DIETHYLAMINOETHANOL
Dangerous Goods Code: 3(31C)
UN Number: 2686

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XI
Risk Phrases:
R 10 Flammable.
R 36/37/38 Irritating to eyes, respiratory system
and skin.
Safety Phrases:
S 28A After contact with skin, wash immediately with
plenty of water.
WGK (Water Danger/Protection)
CAS# 100-37-8: 1
United Kingdom Occupational Exposure Limits
CAS# 100-37-8: OES-United Kingdom, TWA 10 ppm TWA; 49 mg/m3 TWA
Canada
CAS# 100-37-8 is listed on Canada's DSL List.
CAS# 100-37-8 is listed on Canada's Ingredient Disclosure List.
Exposure Limits
CAS# 100-37-8: OEL-AUSTRALIA:TWA 10 ppm (50 mg/m3);Skin
OEL-AUSTRIA:TWA 10 ppm (50 mg/m3);Skin
OEL-BELGIUM:TWA 10 ppm (48 mg/m3);Skin
OEL-DENMARK:TWA 10 ppm (50 mg/m3);Skin
OEL-FINLAND:STEL 10 ppm (50 mg/m3);Skin
OEL-FRANCE:TWA 10 ppm (50 mg/m3);Skin
OEL-GERMANY:TWA 10 ppm (50 mg/m3);Skin
OEL-THE NETHERLANDS:TWA 10 ppm (50 mg/m3);Skin
OEL-THE PHILIPPINES:TWA 10 ppm (50 mg/m3);Skin
OEL-RUSSIA:STEL 5 mg/m3;Skin
OEL-SWITZERLAND:TWA 10 ppm (50 mg/m3);Skin
OEL-UNITED KINGDOM:TWA 10 ppm (50 mg/m3);Skin
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGI TLV
US FEDERAL
TSCA
CAS# 100-37-8 is listed on the TSCA inventory.

SECTION 16 - ADDITIONAL INFORMATION
N/A

毒理学数据:

1.急性毒性

LD50：1300mg/kg（大鼠经口）；1260mg/kg（兔经皮）

2.刺激性

家兔经皮：500mg，轻度刺激（开放性刺激试验）。

家兔经眼：5mg，重度刺激。

生态学数据:

1.生态毒性 LC50：1780mg/L（96h）（黑头呆鱼）；＞1000mg/L（96h）（青鳉）

2.生物降解性暂无资料

3.非生物降解性暂无资料

4.其他有害作用该物质对环境可能有危害，对水体应给予特别注意。

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KK5075000

CHEMICAL NAME :: Ethanol, 2-(diethylamino)-

CAS REGISTRY NUMBER :: 100-37-8

LAST UPDATED :: 199712

DATA ITEMS CITED :: 46

MOLECULAR FORMULA :: C6-H15-N-O

MOLECULAR WEIGHT :: 117.22

WISWESSER LINE NOTATION :: Q2N2&2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 26,269,1944

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 6/11/1963

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 6/11/1963 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Human

DOSE/DURATION :: 200 ppm

TOXIC EFFECTS :: Gastrointestinal - nausea or vomiting

REFERENCE :: 34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969 Volume(issue)/page/year: -,216,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 26,269,1944

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4500 mg/m3/4H

TOXIC EFFECTS :: Brain and Coverings - recordings from specific areas of CNS Sense Organs and Special Senses (Eye) - conjunctive irritation Behavioral - convulsions or effect on seizure threshold

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 14(11),52,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1220 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 12,486,1968

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5000 mg/m3

TOXIC EFFECTS :: Brain and Coverings - recordings from specific areas of CNS Sense Organs and Special Senses (Eye) - conjunctive irritation Behavioral - convulsions or effect on seizure threshold

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 14(11),52,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 192 mg/kg

TOXIC EFFECTS :: Behavioral - ataxia

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 94,249,1948

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 650 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - other changes

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,31,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 188 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,31,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 416 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,31,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1260 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 6/11/1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1 mL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 26,269,1944

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 1300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969 Volume(issue)/page/year: -,216,1969 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 ppm/6H/5D-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi Related to Chronic Data - death

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 26,479,1965

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 ppm/6H/26W-I

TOXIC EFFECTS :: Related to Chronic Data - death

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 26,479,1965

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 76 ppm/6H/14W-I

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 18,418,1992

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 301 ppm/6H/2W-I

TOXIC EFFECTS :: Behavioral - fluid intake Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 18,418,1992

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 21559 mg/kg/1Y-C

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0530455-1 *** REVIEWS *** ACGIH TLV-TWA 9.6 mg/m3 (2 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 10 ppm (50 mg/m3) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,85,1971 OSHA PEL (Gen Indu):8H TWA 10 ppm (50 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 10 ppm (50 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 10 ppm (50 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 10 ppm (50 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 10 ppm (50 mg/m3);Skin JAN 1993 OEL-AUSTRIA:TWA 10 ppm (50 mg/m3);Skin JAN 1993 OEL-BELGIUM:TWA 10 ppm (48 mg/m3);Skin JAN 1993 OEL-DENMARK:TWA 10 ppm (50 mg/m3);Skin JAN 1993 OEL-FINLAND:STEL 10 ppm (50 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 10 ppm (50 mg/m3);Skin JAN 1993 OEL-GERMANY:TWA 10 ppm (50 mg/m3);Skin JAN 1993 OEL-THE NETHERLANDS:TWA 10 ppm (50 mg/m3);Skin JAN 1993 OEL-THE PHILIPPINES:TWA 10 ppm (50 mg/m3);Skin JAN 1993 OEL-RUSSIA:STEL 5 mg/m3;Skin JAN 1993 OEL-SWITZERLAND:TWA 10 ppm (50 mg/m3);Skin JAN 1993 OEL-UNITED KINGDOM:TWA 10 ppm (50 mg/m3);Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO 2-DIETHYLAMINOETHANOL-air:10H TWA 10 ppm (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 24930 No. of Facilities: 7801 (estimated) No. of Industries: 71 No. of Occupations: 39 No. of Employees: 23770 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 24930 No. of Facilities: 11825 (estimated) No. of Industries: 115 No. of Occupations: 68 No. of Employees: 106878 (estimated) No. of Female Employees: 20564 (estimated)

符号	GHS02, GHS05, GHS06
信号词	Danger
危害声明	H226-H302-H311 + H331-H314
警示性声明	P210-P280-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338-P370 + P378
个人防护装备	Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
危害码 (欧洲)	C:Corrosive
风险声明 (欧洲)	R10;R20/21/22;R34
安全声明 (欧洲)	S25-S26-S36/37/39-S45
危险品运输编码	UN 2686 8/PG 2
WGK德国	1
RTECS号	KK5075000
包装等级	II
危险类别	8
海关编码	2922192210

上游产品 10
75-21-8 109-89-7 84115-05-9 107-21-1
107-07-3 67-56-1 64-67-5 141-43-5
2002-24-6 75-03-6
下游产品 9
1112-77-2 108978-03-6 55716-11-5 758-48-5
359-70-6 64-17-5 546-88-3 7664-41-7
64-19-7

1.将氯乙醇与氢氧化钠在105℃下进行反应，生成环氧乙烷，通入二乙胺溶液中进行反应，在常压下分出低沸物后，减压分馏得N，N-二乙基乙醇胺成品。目前大部分生产厂直接用环氧乙烷作原料。

精制方法：常压或减压蒸馏精制。

2.以二乙胺和环氧乙烷原料，将环氧乙烷加入二乙胺中，在一定温度下反应，所得粗品经减压蒸馏成纯品。反应式如下：

海关编码	2922192210
中文概述	2922192210 2－二乙氨基乙醇〔或称N,N－二乙基乙醇胺〕。监管条件:3(两用物项和技术出口许可证)。增值税率:17.0%。退税率:9.0%。最低关税:6.5%。普通关税:30.0%
申报要素	品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装
监管条件	3.两用物项和技术出口许可证
Summary	2922192210 2-(diethylamino)ethanol。supervision conditions:3(export license for dual-use item and technologies)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:30.0%

100-37-8	4620-71-7
13989-32-7	14426-20-1
10369-83-2	1004-37-1
113-48-4	53404-34-5
3616-57-7	14610-73-2
1158522-08-7	940364-43-2
134104-43-1	26093-30-1
131615-57-1	6906-52-1
930439-75-1	893789-98-5
941963-09-3	1018584-77-4