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550-28-7

550-28-7结构式
550-28-7结构式
  • 常用中文名:阿米美啶
  • 常用英文名:Amisometradine
  • CAS号:550-28-7
  • 分子式:C9H13N3O2
  • 分子量:195.21800
  • 发布时间:2018-04-11 08:00:00
  • 更新时间:2024-01-05 21:30:28
  • Amisometradine is a diuretic which may be used in the treatment of congestive heart failure.

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中文名 阿米美啶
英文名 6-amino-3-methyl-1-(2-methylprop-2-enyl)pyrimidine-2,4-dione
英文别名 Aminoisometradin
6-Amino-1-metallyl-3-methylpyrimidine-2,4-dione
AMISOMETRADINE
Aminoisometradine
Amisometradin
Rolicton
6-Amino-1-methallyl-3-methyl-1H-pyrimidin-2,4-dion
Amisometradinum [INN-Latin]
6-Amino-3-methyl-1-(2-methylallyl)uracil
Uracil,6-amino-3-methyl-1-(2-methylallyl)
6-amino-1-methallyl-3-methyl-1H-pyrimidine-2,4-dione
6-amino-3-methyl-1-(2-methyl-allyl)-1H-pyrimidine-2,4-dione
Amisometradina [INN-Spanish]
密度 1.176g/cm3
沸点 292.1ºC at 760 mmHg
分子式 C9H13N3O2
分子量 195.21800
闪点 130.5ºC
精确质量 195.10100
PSA 70.02000
LogP 0.28650
折射率 1.537
储存条件 库房通风低温干燥
计算化学

1.疏水参数计算参考值(XlogP):0.2

2.氢键供体数量:1

3.氢键受体数量:3

4.可旋转化学键数量:2

5.互变异构体数量:3

6.拓扑分子极性表面积:66.6

7.重原子数量:14

8.表面电荷:0

9.复杂度:333

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YQ8800000
CHEMICAL NAME :
Uracil, 6-amino-3-methyl-1-(2-methylallyl)-
CAS REGISTRY NUMBER :
550-28-7
BEILSTEIN REFERENCE NO. :
0182347
LAST UPDATED :
199612
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C9-H13-N3-O2
MOLECULAR WEIGHT :
195.25
WISWESSER LINE NOTATION :
T6NVNVJ A1Y1&U1 C1 FZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1560 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 126,400,1960
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
515 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 126,400,1960
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
610 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,79,1989
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
415 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,79,1989

海关编码 2933599090

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550-28-7结构式

550-28-7

文献:Papesch; Schroeder Journal of Organic Chemistry, 1951 , vol. 16, p. 1879,1881,1887

~%

550-28-7结构式

550-28-7

文献:Papesch; Schroeder Journal of Organic Chemistry, 1951 , vol. 16, p. 1879,1881,1887

~%

550-28-7结构式

550-28-7

文献:Papesch; Schroeder Journal of Organic Chemistry, 1951 , vol. 16, p. 1879,1881,1887
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海关编码 2933599090
中文概述 2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素 品名, 成分含量, 用途, 乌洛托品请注明外观, 6-己内酰胺请注明外观, 签约日期
Summary 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%