472-26-4

• 常用中文名：远华蟾蜍精
• 常用英文名：Telocinobufagin
• CAS号：472-26-4
• 分子式：C₂₄H₃₄O₅
• 分子量：402.524
• 相关类别： 生物化工 中草药成分
• 发布时间：2018-08-16 22:16:48
• 更新时间：2024-01-02 18:31:28
• 远华蟾蜍精(Telocinobufagin)是蟾酥分离提取的一种组份。

名称

• 中文名: 蟾蜍精
• 英文名: 5-[(3S,5S,8R,9S,10R,13R,14S,17R)-3,5,14-trihydroxy-10,13-dimethyl-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]pyran-2-one
• 英文别名: 3,5,14-Trihydroxybufa-20,22-dienolide; Telobufotoxin; 5β-Bufa-20,22-dienolide, 3β,5,14-trihydroxy-; Telecinobufagin; Telocinobufogenin; (3β,5β)-3,5,14-Trihydroxybufa-20,22-dienolide; Bufa-20,22-dienolide, 3,5,14-trihydroxy-, (3β,5β)-; Telocinobufagin

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 589.6±50.0 °C at 760 mmHg
• 分子式: C₂₄H₃₄O₅
• 分子量: 402.524
• 闪点: 201.0±23.6 °C
• 精确质量: 402.240631
• PSA: 90.90000
• LogP: 1.78
• 蒸汽压: 0.0±3.8 mmHg at 25°C
• 折射率: 1.624
• 储存条件: -20°C

生物活性

• 描述: 远华蟾蜍精(Telocinobufagin)是蟾酥分离提取的一种组份。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 其他
  天然产物 >> 类固醇

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : EI2996700 CHEMICAL NAME : 5-beta-Bufa-20,22-dienolide, 3-beta,5,14-trihydroxy- CAS REGISTRY NUMBER : 472-26-4 BEILSTEIN REFERENCE NO. : 0056287 LAST UPDATED : 199709 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C24-H34-O5 MOLECULAR WEIGHT : 402.58 WISWESSER LINE NOTATION : L E5 B666TJ A1 E1 IQ MQ OQ F- ET6OVJ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 4340 ug/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - antipsychotic REFERENCE : CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 24,1714,1976 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 102 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PHUZBI Pharmazie in Unserer Zeit. (VCH Pub., Inc., 303 N.W. 12th Ave., Deerfield Beach, FL 33441) V.1- 1972- Volume(issue)/page/year: 13,129,1984 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - cat DOSE/DURATION : 100 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85ELDJ "Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster, Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963 Volume(issue)/page/year: -,194,1963 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Mammal - cat DOSE/DURATION : 1102 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PHUZBI Pharmazie in Unserer Zeit. (VCH Pub., Inc., 303 N.W. 12th Ave., Deerfield Beach, FL 33441) V.1- 1972- Volume(issue)/page/year: 13,129,1984

合成路线

64-17-5 64-19-7 470-42-8 ~% 472-26-4

文献：Bharucha et al. Helvetica Chimica Acta, 1959 , vol. 42, p. 1395,1397

上下游产品

上游产品  3
64-17-5 64-19-7 470-42-8
下游产品  0