470-42-8

• 常用中文名：海蟾蜍毒素
• 常用英文名：Marinobufogenin
• CAS号：470-42-8
• 分子式：C₂₄H₃₂O₅
• 分子量：400.508
• 相关类别： 研究领域 其他
• 发布时间：2018-06-11 21:59:23
• 更新时间：2024-01-04 16:58:44
• Marinobufogenin 是 Na+/K+ ATPase 的高效抑制剂,最初从哺乳动物血浆中鉴定得到。

名称

• 中文名: 海蟾蜍毒素
• 英文名: Marinobufagenin
• 英文别名: (3β,5β,15β)-3,5-Dihydroxy-14,15-epoxybufa-20,22-dienolide; 5β-Bufa-20,22-dienolide, 14,15β-epoxy-3β,5-dihydroxy-; 5beta-Bufa-20,22-dienolide,14,15beta-epoxy-3beta,5-dihydroxy; Bufa-20,22-dienolide,14,15-epoxy-3,5-dihydroxy-,(3beta,5beta,15beta); Marinobufagenin; Marinobufogenin; Marinobufagin; Bufa-20,22-dienolide, 14,15-epoxy-3,5-dihydroxy-, (3β,5β,15β)-; MARCINOBUFAGIN; 5-hydroxyl-resibufogenin

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 589.0±50.0 °C at 760 mmHg
• 分子式: C₂₄H₃₂O₅
• 分子量: 400.508
• 闪点: 203.0±23.6 °C
• 精确质量: 400.224976
• PSA: 83.20000
• LogP: 1.25
• 蒸汽压: 0.0±3.7 mmHg at 25°C
• 折射率: 1.621
• 储存条件: 2-8°C，避光，干燥，密封

生物活性

• 描述: Marinobufogenin 是 Na+/K+ ATPase 的高效抑制剂,最初从哺乳动物血浆中鉴定得到。
• 相关类别:
  研究领域 >> 其他
• 靶点:

  IC50: Na+/K+ ATPase[1]

• 参考文献:

  [1]. Daniel N, et al. Bufodienolides in pig plasma and urine.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : EI2963000 CHEMICAL NAME : 5-beta-Bufa-20,22-dienolide, 3-beta,5-dihydroxy-14,15-beta-epoxy- CAS REGISTRY NUMBER : 470-42-8 LAST UPDATED : 199009 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C24-H32-O5 MOLECULAR WEIGHT : 400.56 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2730 ug/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - antipsychotic REFERENCE : CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 24,1714,1976 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 152 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PHUZBI Pharmazie in Unserer Zeit. (VCH Pub., Inc., 303 N.W. 12th Ave., Deerfield Beach, FL 33441) V.1- 1972- Volume(issue)/page/year: 13,129,1984 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - cat DOSE/DURATION : 1520 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JMPCAS Journal of Medicinal and Pharmaceutical Chemistry. (Washington, DC) V.1-5, 1959-62. For publisher information, see JMCMAR. Volume(issue)/page/year: 3,111,1961 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Mammal - cat DOSE/DURATION : 556 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PHUZBI Pharmazie in Unserer Zeit. (VCH Pub., Inc., 303 N.W. 12th Ave., Deerfield Beach, FL 33441) V.1- 1972- Volume(issue)/page/year: 13,129,1984 *** REVIEWS *** TOXICOLOGY REVIEW 85ELDJ "Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster, Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963 Volume(issue)/page/year: -,192,1963

安全

• 危害码 (欧洲): Xi

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