CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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SH5450000
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CHEMICAL NAME :
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Phenethylamine, N,alpha-dimethyl-, hydrochloride, (+-)-
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CAS REGISTRY NUMBER :
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4298-16-2
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LAST UPDATED :
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199712
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DATA ITEMS CITED :
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5
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MOLECULAR FORMULA :
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C10-H15-N.Cl-H
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MOLECULAR WEIGHT :
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185.72
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WISWESSER LINE NOTATION :
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1MY1&1R &GH -R
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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54480 ug/kg
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TOXIC EFFECTS :
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Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Lungs, Thorax, or Respiration - other changes
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REFERENCE :
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JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 37,223,1948
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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143 mg/kg
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TOXIC EFFECTS :
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Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Lungs, Thorax, or Respiration - other changes
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REFERENCE :
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JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 37,223,1948
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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57190 ug/kg
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TOXIC EFFECTS :
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Behavioral - convulsions or effect on seizure threshold
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REFERENCE :
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JANCA2 Journal of the Association of Official Analytical Chemists. (Assoc. of Official Analytical Chemists, 1111 N. 19th St., Suite 210, Arlington, VA 22209) V.49- 1966- Volume(issue)/page/year: 68,1213,1985 ** OTHER MULTIPLE DOSE TOXICITY DATA **
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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700 mg/kg/98D-I
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TOXIC EFFECTS :
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Cardiac - cardiomegaly Gastrointestinal - other changes Related to Chronic Data - death
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REFERENCE :
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JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 37,223,1948 ** REPRODUCTIVE DATA **
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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DOSE :
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84 mg/kg
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SEX/DURATION :
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female 1-21 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Effects on Newborn - biochemical and metabolic Reproductive - Effects on Newborn - behavioral
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REFERENCE :
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SYNAET Synapse. (Wiley-Liss, Inc., 605 Third Ave., New York, NY USA 10158-0012) V.1- 1987- Volume(issue)/page/year: 13,241,1993
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