140924-50-1

• 常用中文名：氢化奎宁 1,4-(2,3-二氮杂萘)二醚
• 常用英文名：(DHQ)2PHAL
• CAS号：140924-50-1
• 分子式：C₄₈H₅₄N₆O₄
• 分子量：778.980
• 相关类别： 化学试剂 手性化学试剂
• 发布时间：2018-12-25 13:31:59
• 更新时间：2026-07-02 11:20:56
• 【用途一】
  配体，用于不饱和酯和三取代 C=C 键的非对称二羟基化。

名称

• 中文名: 氢化奎宁 1,4-(2,3-二氮杂萘)二醚
• 英文名: 4-[(R)-[(2R,4S,5R)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methoxy]-1-[(R)-[(2R,4R,5S)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methoxy]phthalazine
• 中文别名: 1,4-双((R)-((1S,2S,4S,5R)-5-乙基奎宁环丁-2-基)(6-甲氧基喹啉-4-基)甲氧基)酞嗪; 手性催化剂; 氢化奎宁1,4-酞嗪二醚; 双羟化配体((DHQ)2PHAL); 氢化奎宁1,4-(2,3-二氮杂荼)二醚; 氢化奎宁1,4-(2,3-二氮杂萘)二醚 (DHQ)2PHAL; (DHQ)2PHAL 双羟化配体; (+)-氢化奎宁1,4-(2,3-二氮杂萘)二醚; 氢化奎宁 1,4-(2,3-二氮杂; 双羟化配体; 1,4(9-O-二氢奎宁)酞嗪
• 英文别名: 4-[(R)-[(2S,4R,5R)-5-ethylquinuclidin-2-yl]-(6-methoxy-4-quinolyl)methoxy]-1-[(R)-[(2S,4S,5R)-5-ethylquinuclidin-2-yl]-(6-methoxy-4-quinolyl)methoxy]phthalazine; 1,4-Bis(9-O-dihydroquininyl)phthalazine; 4-((R)-((2S)-5-ethylquinuclidin-2-yl)(6-methoxyquinolin-4-yl)methoxy)-1-((R)-((2S,4R)-8-ethylquinuclidin-2-yl)(6-methoxyquinolin-4-yl)methoxy)phthalazine; (8a,9R,8'''a,9'''R)-9,9'-[Phthalazine-1,4-diylbis(oxy)]bis(6'-methoxy-10,11-dihydrocinchonan); Hydroquinine 1,4-Phthalazinediyl Diether; 1,4-Bis((1R)-((1S,2S,4S)-5-ethylquinuclidin-2-yl)(6-methoxyquinolin-4-yl)methoxy)phthalazine; 1,4-Bis(dihydroquinine)phthalazine; 1,4-Bis((R)-((1S,2S,4S,5R)-5-ethylquinuclidin-2-yl)(6-methoxyquinolin-4-yl)methoxy)phthalazine; 1,4-bis[(R)-[(1S,2S,4S)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl](6-methoxyquinolin-4-yl)methoxy]phthalazine; Cinchonan, 9,4-phthalazinediylbis(oxy)bis10,11-dihydro-6-methoxy-, (8.alpha.,9R)-(8.alpha.,9R); (DHQ)2PHAL,e.e; (+)-(DHQ)2PHAL; 5,6-dihydro-[1,2]dithiolo[4,5-b][1,4]dithiin-2-one; Cinchonan, 9,9''-[1,4-phthalazinediylbis(oxy)]bis[10,11-dihydro-6'-methoxy-, (8α,9R)-(8''α,9''R); (DHQ)2 PHAL; (R,R)-(DHQ)2PHAL; (8α,9R,8'''α,9'''R)-9,9'-[1,4-Phthalazinediylbis(oxy)]bis(6'-methoxy-10,11-dihydrocinchonan); 4,5-Ethylenedithio-1,3-dithiol-2-one; (DHQ)PHAL; hydroquinine 1,4-phthalazinediyl diether; (Dhq)2phal Hydroquinine 1,4-phthalazinediyl diether; (8α,9R,8'''α,9'''R)-9,9'-[Phthalazine-1,4-diylbis(oxy)]bis(6'-methoxy-10,11-dihydrocinchonan); MFCD00191975; Tianfu Chem (DHQ)2PHAL; Hydroquinine 1,4-phthalazinediyl diether((DHQ)2PHAL）; 4-[(R)-[(2R,4S,5R)-5-ethyl-1-azabicyclo [2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methoxy]-1-[(R)-[(2R,4R,5S)-5-ethyl-1-azabicyclo [2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methoxy]phthalazine

物化性质

• 密度: 1.3±0.1 g/cm3
• 熔点: 178ºC (dec.)
• 分子式: C₄₈H₅₄N₆O₄
• 分子量: 778.980
• 精确质量: 778.420654
• PSA: 94.96000
• LogP: 9.20
• 外观性状: 固体;White to Light yellow powder to crystal
• 折射率: 1.688
• 储存条件: 存放于惰性气体之中;避免空气

安全

• 符号: GHS07
• 信号词: Warning
• 危害声明: H317
• 警示性声明: P280
• 个人防护装备: Eyeshields;Faceshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 危害码 (欧洲): Xi
• 安全声明 (欧洲): S22-S24/25
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 3
• 海关编码: 2933990090

合成路线

4752-10-7 522-66-7 ~% 140924-50-1

文献：Journal of Organic Chemistry, , vol. 57, # 10 p. 2768 - 2771

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海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%