23291-96-5

• 常用中文名：脱氢野百合碱
• 常用英文名：Dehydromonocrotaline
• CAS号：23291-96-5
• 分子式：C₁₆H₂₁NO₆
• 分子量：323.34100
• 发布时间：2017-12-03 06:47:41
• 更新时间：2025-08-21 09:59:54

名称

• 中文名: 脱氢野百合碱
• 英文名: Dehydromonocrotaline
• 英文别名: Monocrotaline, 3,8-didehydro; (13R,14R)-3,8-Didehydro-14,19-dihydro-12,13-dihydroxy-20-norcrotalanan-11,15-dione; 20-Norcrotalanan-11,15-dione, 3,8-didehydro-14,19-dihydro-12,13-dihydroxy-, (13-alpha,14-alpha); 2H-[1,6]Dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6(3H)-dione, 4,5,8,12,13,13a-hexahydro-4,5-dihydroxy-3,4,5-trimethyl-, (3R,4R,5R,13); 2H-(,6)Dioxacyclounlecino(2,3,4-gh)pyrrolizine-2,6(3H)-dione, 4,5,8,12,13,13A-hexahydro-4,5-dihydroxy-3,4,5-trimethyl-, (3R,4R,5R,13); |A,|A-Dehydrolovastatin; Monocrotaline pyrrole metabolite; monocrotaline pyrrole; 2H-(,6)Dioxacyclounlecino(2,3,4-gh)pyrrolizine-2,6(3H)-dione, 4,5,8,12,13,13A-hexahydro-4,5-dihydroxy-3,4,5-trimethyl-, (3R-(3R*,4R*,5R*,13*)); Dehydromonacolin K; Dehydro Lovastatin

物化性质

• 密度: 1.43g/cm3
• 沸点: 557ºC at 760mmHg
• 分子式: C₁₆H₂₁NO₆
• 分子量: 323.34100
• 闪点: 290.6ºC
• 精确质量: 323.13700
• PSA: 97.99000
• LogP: 0.67100
• 蒸汽压: 3.06E-13mmHg at 25°C
• 折射率: 1.62

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : RC1250000 CHEMICAL NAME : 20-Norcrotalanan-11,15-dione, 3,8-didehydro-14,19-dihydro-12,13-dihydroxy-, (13-alpha,14- alpha)- CAS REGISTRY NUMBER : 23291-96-5 LAST UPDATED : 199606 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C16-H21-N-O6 MOLECULAR WEIGHT : 323.38 WISWESSER LINE NOTATION : T55-11- 1A P EN IOV NVO BU FUTJ K1 LQ L1 MQ M1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 16 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - other changes Liver - other changes REFERENCE : CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 12,299,1976 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 5 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - other changes REFERENCE : JPTLAS Journal of Pathology. (John Wiley & Sons, Inc., 605 Third Ave., New York, NY 10158) V.97- 1969- Volume(issue)/page/year: 100,169,1970 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 3 mg/kg/5W-I TOXIC EFFECTS : Skin and Appendages - dermatitis, other (after systemic exposure) REFERENCE : JPTLAS Journal of Pathology. (John Wiley & Sons, Inc., 605 Third Ave., New York, NY 10158) V.97- 1969- Volume(issue)/page/year: 118,121,1976 ** TUMORIGENIC DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1504 mg/kg/47W-I TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application REFERENCE : CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 17,61,1982

合成路线

315-22-0 ~% 23291-96-5

文献：Chemico-Biological Interactions, , vol. 183, # 1 p. 49 - 56

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