136310-64-0

• 常用中文名：2-(2-噻吩基)乙醇酸东莨菪酯
• 常用英文名：Scopine Di(2-thienyl) Glycolate
• CAS号：136310-64-0
• 分子式：C₁₈H₁₉NO₄S₂
• 分子量：377.478
• 相关类别： 生物化工 中草药成分
• 发布时间：2019-01-01 12:03:23
• 更新时间：2026-06-30 10:35:18

名称

• 中文名: 二(2-噻吩基)乙醇酸东莨菪酯
• 英文名: Scopine di(2-thienyl)glycolate
• 中文别名: 中间体2-(2-噻吩基)乙醇酸东莨菪酯; 2-(2-噻吩基)乙醇酸东莨菪酯(中三); 噻托溴铵P2; 噻托溴铵杂质B; 噻托溴铵中间体2; 2-(2-嘍吩基)乙醇酸东莨若酯; SCOPINE DI(2-THIENYL) GLYCOLATE 2-(2-噻吩基)乙醇酸东莨菪酯; REL-(1R,2R,4S,5S,7S)-9-甲基-3-氧杂-9-氮杂三环[3.3.1.02,4]壬烷-7-基 2-羟基-2,2-二(噻吩-2-基)乙酸酯; 噻托溴铵杂质2(噻托溴铵杂质B); 噻托溴铵一水合物杂质B; 2,2-二噻吩基乙醇酸东莨菪酯
• 英文别名: (1R,2R,4S,5S,7s)-9-Methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7-yl 2-Hydroxy-2,2-dithiophen-2-ylace; Tiotropium Bromide Impurity B; 2-Thiopheneacetic acid, -hydroxy-2-thienyl-, (1,2,4,5,7); Scopolamine 2-(2-thienyl)glycolate; 2-thiopheneacetic acid, a-hydroxy-a-2th ( Di(2-thienyl) Glycolate ); Scopine Di(2-thienylglycolate); (1R,2R,4S,5S,7s)-9-Methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7-yl 2-hydroxy-2,2-dithiophen-2-ylacetate; High purity Scopine-2,2-dithienyl glycolate in stock; Scopine-2,2-dithienyl glycolate; SCOPINE-2,2-DITHIENYL GLYCOLATE; (1R,2R,4S,5S,7S)-9-methyl-3-oxa-9-azatricyclo[3.3.1.0]non-7-yl hydroxy(dithiophen-2-yl)acetate; Scopine di (2-thienyl) glycolate Intermediate; N-DeMethyl TiotropiuM; N-Desmethyl Tiotropium; 2-Thiopheneacetic acid, α-hydroxy-α-2-thienyl-, (1α,2β,4β,5α,7β)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl ester; Tiotropium Impurity B; Scopine di(2-thienyl)glycolate scopine-2-dithienyl glycolate; Tiotropium Bromide Monohydrate Impurity B; Scopolamine 2- (2-thiophenyl) glycolate; 2-(2-Thienyl)glycolic Acid Scopolamine Ester; rel-(1R,2R,4S,5S,7s)-9-Methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7-yl 2-hydroxy-2,2-di(thiophen-2-yl)acetate; Scopine-2,2-dithienyl glycolate //BP; CO base bis (2-thiophenyl) glycolate; α-Hydroxy-α-2-thienyl-2-thiopheneacetic Acid (1α,2β,4β,5α,7β)-9-Methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl Ester; Tiotropium Bromide Impurity 2(Tiotropium Bromide Impurity B); 2-Thiopheneacetic acid, α-hydroxy-α-2-thienyl-, (1R,2R,4S,5S)-9-methyl-3-oxa-9-azatricyclo[3.3.1.0]non-7-yl ester; (1R,2R,4S,5S,7s)-9-Methyl-3-oxa-9-azatricyclo[3.3.1.0]non-7-yl hydroxy(di-2-thienyl)acetate

物化性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 542.3±50.0 °C at 760 mmHg
• 熔点: 138-140°C
• 分子式: C₁₈H₁₉NO₄S₂
• 分子量: 377.478
• 闪点: 281.7±30.1 °C
• 精确质量: 377.075562
• PSA: 118.78000
• LogP: 2.26
• 蒸汽压: 0.0±1.5 mmHg at 25°C
• 折射率: 1.688
• 储存条件: -20°C Freezer

安全

• 危害码 (欧洲): Xi

合成路线

26447-85-8 498-45-3 ~72% 136310-64-0

文献：WO2013/46138 A1, ; Page/Page column 9; 10 ;

136310-66-2 ~78% 136310-64-0

文献：Australian Journal of Chemistry, , vol. 59, # 1 p. 53 - 58

26447-85-8 1449372-70-6 ~% 136310-64-0

文献：WO2013/117886 A1, ; Paragraph 00033 ;

26447-85-8 85700-55-6 ~61% 136310-64-0

文献：WO2009/87419 A1, ; Page/Page column 13 ;

1454836-37-3 5713-61-1 ~% 136310-64-0

文献：WO2013/135219 A1, ; Page/Page column 12-13 ;

672-21-9 ~% 136310-64-0

文献：Australian Journal of Chemistry, , vol. 59, # 1 p. 53 - 58

22150-33-0 ~% 136310-64-0

文献：Australian Journal of Chemistry, , vol. 59, # 1 p. 53 - 58

20513-09-1 ~% 136310-64-0

文献：Australian Journal of Chemistry, , vol. 59, # 1 p. 53 - 58

498-45-3 ~% 136310-64-0

文献：WO2013/135219 A1, ;