CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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DV5355000
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CHEMICAL NAME :
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Biphenyl, 3,3',4,4',5,5'-hexachloro-
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CAS REGISTRY NUMBER :
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32774-16-6
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BEILSTEIN REFERENCE NO. :
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1990183
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LAST UPDATED :
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199612
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DATA ITEMS CITED :
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8
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MOLECULAR FORMULA :
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C12-H4-Cl6
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MOLECULAR WEIGHT :
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360.86
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WISWESSER LINE NOTATION :
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GR BG CG DR CG DG EG
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - guinea pig
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DOSE/DURATION :
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223 ug/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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PSSID2 Pergamon Series on Environmental Science. (Oxford, UK) V.1-7, 1978-82. Discontinued. Volume(issue)/page/year: 5,367,1982 ** OTHER MULTIPLE DOSE TOXICITY DATA **
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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58800 ug/kg/28D-C
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TOXIC EFFECTS :
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Liver - multiple effects Endocrine - other changes Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
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REFERENCE :
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TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 58,461,1981
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Mammal - species unspecified
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DOSE/DURATION :
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12700 mg/kg/19W-C
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TOXIC EFFECTS :
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Liver - changes in liver weight Skin and Appendages - nails Related to Chronic Data - death
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REFERENCE :
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AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 16,53,1987 ** REPRODUCTIVE DATA **
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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37800 ug/kg
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SEX/DURATION :
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female 1-21 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Maternal Effects - other effects Reproductive - Effects on Newborn - behavioral Reproductive - Effects on Newborn - other postnatal measures or effects
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REFERENCE :
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CMSHAF Chemosphere. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1972- Volume(issue)/page/year: 27,395,1993
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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10 mg/kg
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SEX/DURATION :
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female 6-15 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Specific Developmental Abnormalities - hepatobiliary system
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REFERENCE :
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TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 61,269,1981
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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80 mg/kg
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SEX/DURATION :
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female 6-15 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
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REFERENCE :
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TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 61,269,1981
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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40 mg/kg
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SEX/DURATION :
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female 6-15 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death
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REFERENCE :
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APTOD9 Abstracts of Papers, Society of Toxicology. Annual Meetings. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) Volume(issue)/page/year: 19,A22,1980
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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20 mg/kg
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SEX/DURATION :
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female 5-15 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - urogenital system
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REFERENCE :
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APTOD9 Abstracts of Papers, Society of Toxicology. Annual Meetings. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) Volume(issue)/page/year: 19,A22,1980
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