94413-64-6

• 常用中文名：2-氰基-4-吡啶羧酸甲酯
• 常用英文名：Methyl 2-cyanoisonicotinate
• CAS号：94413-64-6
• 分子式：C₈H₆N₂O₂
• 分子量：162.145
• 相关类别： 医药中间体 杂环化合物 吡啶类化合物 氰基吡啶
• 发布时间：2018-09-18 13:56:47
• 更新时间：2026-07-01 17:30:22

名称

• 中文名: 2-氰基-4-吡啶羧酸甲酯
• 英文名: Methyl 2-cyanoisonicotinate
• 中文别名: 托匹司他中间体一; 2-CYANO PYRIDINE(2-氰基吡啶); 托比司他中间体; 托匹司他杂质36; 甲基 2-氰基异烟酸酯; 托吡司他中间体; 2-氰基-4-吡啶羧酸甲酯(托匹司他中间体); 2-氰基-4-吡啶甲酸甲酯; 托匹司他中间体2; 2-氰基异烟酸甲酯; 2-氰基-4-吡啶羧酸甲酯94-6,托匹司他中间体; 托匹司他及其中间体; 2-氰基异氰酸酯
• 英文别名: 2-Cyanoisonicotinic acid methyl ester; 2-Cyanoisonicotinate methyl ester; 4-Pyridinecboxylicacid, 2-cyano-, Methyl ester; Methyl 2-cyanopyridine-4-cboxylate; F2-Cyano-4-Pyridine Cboxylic Acid Methyl Ester; 2-CYANO-4-PYRIDINE CBOXYLIC ACID METHYL ESTER; 2-Cyano-4-cbomethoxypyridine; Methyl 2-cyanoisonicotinae; 2-cyanoisonicotinate; 2-Cyano-4-pyridine carboxylic acid methyl ester; Methyl 2-cyanois; 2-CYANO-4-PYRIDINE CBOXYLIC ACID METHYL ESTER ISO 9001：2015 REACH; 4-Pyridinecarboxylic acid, 2-cyano-, methyl ester; methyl 2-cyanopyridine-4-carboxylate; Methyl2-cyanoisonicotinate; Methyl 2-cyano-4-pyridinecboxylate

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 296.6±25.0 °C at 760 mmHg
• 熔点: 107-109℃
• 分子式: C₈H₆N₂O₂
• 分子量: 162.145
• 闪点: 133.2±23.2 °C
• 精确质量: 162.042923
• PSA: 62.98000
• LogP: 0.85
• 外观性状: Solid | Pale brown
• 蒸汽压: 0.0±0.6 mmHg at 25°C
• 折射率: 1.536
• 储存条件: 室温， 惰性气体
• 水溶解性: Slightly Soluble in water (6.2 g/L) (25°C).

安全

• 危害码 (欧洲): Xi
• 海关编码: 2933399090

合成路线

3783-38-8 7677-24-9 ~58% 94413-64-6

文献：GENENTECH,INC.; FORMA TM, LLC; BAIR, Kenneth W.; BAUMEISTER, Timm R.; BUCKMELTER, Alexandre J.; CLODFELTER, Kanl H.; DRAGOVICH, Peter; HAN, Bingsong; LIN, Jian; LIU, Xiongcai; REYNOLDS, Dominic J.; SMITH, Chase C.; WANG, Zhongguo; YUEN, Po-Wai; ZAK, Mark; ZHANG, Yamin; ZHENG, Xiaozhang; ZHAO, Guiling Patent: WO2013/127268 A1, 2013 ; Location in patent: Page/Page column 71; 72 ;

773837-37-9 3783-38-8 ~64% 94413-64-6

文献：Sato, Nagaaki; Ando, Makoto; Ishikawa, Shiho; Jitsuoka, Makoto; Nagai, Keita; Takahashi, Hirobumi; Sakuraba, Aya; Tsuge, Hiroyasu; Kitazawa, Hidefumi; Iwaasa, Hisashi; Mashiko, Satoshi; Gomori, Akira; Moriya, Ryuichi; Fujino, Naoko; Ohe, Tomoyuki; Ishihara, Akane; Kanatani, Akio; Fukami, Takehiro Journal of Medicinal Chemistry, 2009 , vol. 52, # 10 p. 3385 - 3396

3783-38-8 ~% 94413-64-6

文献：EP1471065 A1, ; Page 7 ;

3783-38-8 7677-24-9 79-44-7 ~% 94413-64-6

文献：US6509361 B1, ; US 6509361 B1

2459-09-8 ~% 94413-64-6

文献：WO2013/127268 A1, ;

海关

海关编码	2933399090
中文概述	2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%