383365-04-6

• 常用中文名：磷丙替诺福韦
• 常用英文名：Tenofovir alafenamide
• CAS号：383365-04-6
• 分子式：C₂₁H₂₉N₆O₅P
• 分子量：476.466
• 发布时间：2018-07-21 14:09:11
• 更新时间：2026-06-30 12:57:32

名称

• 中文名: 磷丙替诺福韦
• 英文名: 9-[(R)-2-[[(S)-[[(S)-1-(isopropoxycarbonyl)ethyl]amino]-phenoxyphosphinyl]methoxy]propyl]adenine
• 中文别名: 泰诺福韦艾拉酚胺杂质RRS; N-[(R)-[[(1R)-2-(6-氨基-9H-嘌呤-9-基)-1-甲基乙氧基]甲基]苯氧基次膦基]-L-丙氨酸1-甲基乙基酯; 替诺福韦甲酰胺杂质3; 泰诺福韦艾拉酚胺杂质13单体; 替诺福韦杂质48; (S)-丙胺酸异丙酯2-{(R)-[((R)-1-(6-氨基-9H-嘌呤-9-基)-1-甲基乙氧基]甲基}-苯氧基磷酰基; 丙酚替诺福韦杂质13 单体; 替诺福韦艾拉酚胺非对映异构体; 替诺福韦阿拉芬酰胺杂质13; 替诺福韦拉酚氨酯杂质06; 替诺福韦艾拉酚胺杂质E; 替诺福韦艾拉酚胺非对映异构体(RRS); ((R)-((((R)-1-(6-氨基-9H-嘌呤-9-基)丙烷-2-基)氧基)甲基)(苯氧基)磷酰基)-L-丙氨酸异丙酯; 9-[(R)-2-[[(R)-[[(S)-1-(异丙氧基羰基)乙基]氨基]苯氧基氧膦基]甲氧基]丙基]腺嘌呤; (S)-丙胺酸异丙酯 2-{(R)-[((R)-1-(6-氨基-9H-嘌呤-9-基)-1-甲基乙氧基]甲基}-苯氧基磷酰基; 替诺福韦相关化合物6; 替诺福韦艾拉酚胺杂质A2; TAF杂质E; 替诺福韦拉酚氨酯杂质06(单体); 替诺福韦酯杂质6; 替诺福韦相关物质; 富马酸丙酚替诺福韦杂质V; 替诺福韦艾拉酚胺(R-磷化氢)
• 英文别名: TAF-IM-A2; 9-[(R)-2-[[(R)-[[(S)-1-(isopropoxycarbonyl)ethyl]amino](phenoxy)phosphinyl]methoxy]propyl]adenine; Isopropyl N-[(S)-({[(2R)-1-(6-amino-9H-purin-9-yl)-2-propanyl]oxy}methyl)(phenoxy)phosphoryl]-L-alaninate; Tenofovir Alafenamide (R-Phosphine); L-Alanine, N-[(S)-[(1S)-[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-, 1-methylethyl ester; Tenofovir Alafenamide Impurity E; Tenofovir Alafenamide Impurity RRS; (S)-isopropyl 2-(((R)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)amino)propanoate; isopropyl (((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-L-alaninate; L-Alanine,N-[(R)-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-, 1-methylethyl ester; Tenofovir Alafenamide Impurity 3; N-[(R)-[[(1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-L-alanine 1-Methylethyl Ester; Tenofovir Alafenamide Impurity 13 Monomer; Tenofovir Alafenamide Impurity 37; (S)-isopropyl 2-(((R)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)ami; Tenofovir related compound; enofovir Related Compound 6; Tenofovir Impurity 6-d6; Tenofovir Impurity 48; Tenofovir Impurity 6; Tenofovir Related Compound 6; Isopropyl ((R)-((((R)-1-(6-amino-9h-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-l-alaninate; 9-[(R)-2-[[(S)-[[(S)-1-(isopropoxycbonyl)ethyl]amino]-phenoxyphosphinyl]methoxy]propyl]adenine; TAF Impurity E; Tenofovir Alafenamide Diasteromer-1

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 640.4±65.0 °C at 760 mmHg
• 分子式: C₂₁H₂₉N₆O₅P
• 分子量: 476.466
• 闪点: 341.1±34.3 °C
• 精确质量: 476.193695
• PSA: 153.29000
• LogP: 2.20
• 蒸汽压: 0.0±1.9 mmHg at 25°C
• 折射率: 1.630
• 储存条件: 室温