728-88-1

• 常用中文名：托哌酮
• 常用英文名：Tolperisone
• CAS号：728-88-1
• 分子式：C₁₆H₂₃NO
• 分子量：245.36000
• 相关类别： 原料药 循环系统用药 周围血管扩张药
• 发布时间：2018-09-08 09:38:07
• 更新时间：2026-06-30 10:16:27

名称

• 中文名: 托哌酮
• 英文名: 2-methyl-1-(4-methylphenyl)-3-piperidin-1-ylpropan-1-one
• 中文别名: 甲哌酮; 托哌立松; 托派松; 桃卜里松; 脑脉宁
• 英文别名: 2-methyl-3-piperidino-1-p-tolylpropan-1-one; Besnoline (free base); EINECS 211-976-4; 2-methyl-1-(4-methylphenyl)-3-piperidin-1-yl-propan-1-one; Mydetone; TolperisoneQ: What is Tolperisone Q: What is the CAS Number of Tolperisone Q: What is the storage condition of Tolperisone Q: What e the applications of Tolperisone; 1 Tolperisone C16H23NO; 2-methyl-1-(4-methylphenyl)-3-piperidino-propan-1-one; 2,4’-dimethyl-3-piperidino-propiophenon; (RS)-tolperisone; Tolperisone (base and/or unspecified salts); Mydocalm; Mydeton; Atmosgen (free base); 1-Propanone, 2-methyl-1-(4-methylphenyl)-3-(1-piperidinyl)- (9CI); MFCD00242995; 2-methyl-3-(piperidin-1-yl)-1-(p-tolyl)propan-1-one; Atmosgen free base; Besnoline free base; 2-methyl-1-(4-methylphenyl)-3-(1-piperidinyl)-1-propanone; Propiophenone, 2,4'-dimethyl-3-piperidino- (7CI, 8CI); 2,4'-dimethyl-3-piperidinopropiophenone; tolperisone; Roystajin (free base); Mideton; Tolperisone //BP; 2'4-Dimethyl-3-PiperidylPropiophenone; dl-Tolperisone; 2-Methyl-1-(4-methylphenyl)-3-(1-piperidinyl)-1-propanone; 1-piperidino-2-methyl-3-(p-tolyl)-3-propanone; mydeton; Tolperisone free base; 1-Propanone, 2-Methyl-1-(4-Methylphenyl)-3-(1-piperidinyl); 2,4'-Dimethyl-3-piperidinopropiophenone; TOLPERISONE; α,4'-Dimethyl-β-piperidinopropiophenone; 2-methyl-3-piperidin-1-yl-1-p-tolyl-propan-1-one; Menopatol

物化性质

• 密度: 1.004g/cm3
• 沸点: 373.9ºC at 760 mmHg
• 分子式: C₁₆H₂₃NO
• 分子量: 245.36000
• 闪点: 134.4ºC
• 精确质量: 245.17800
• PSA: 20.31000
• LogP: 3.23760
• 折射率: 1.526

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UH1575000 CHEMICAL NAME : Propiophenone, 2,4'-dimethyl-3-piperidino- CAS REGISTRY NUMBER : 728-88-1 BEILSTEIN REFERENCE NO. : 1285666 LAST UPDATED : 199612 DATA ITEMS CITED : 7 MOLECULAR FORMULA : C16-H23-N-O MOLECULAR WEIGHT : 245.40 WISWESSER LINE NOTATION : T6NTJ A1Y1&VR D1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1450 mg/kg TOXIC EFFECTS : Behavioral - changes in motor activity (specific assay) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 5,421,1971 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 170 mg/kg TOXIC EFFECTS : Behavioral - changes in motor activity (specific assay) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 5,421,1971 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 645 mg/kg TOXIC EFFECTS : Behavioral - changes in motor activity (specific assay) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 5,421,1971 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1350 mg/kg TOXIC EFFECTS : Behavioral - changes in motor activity (specific assay) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 5,421,1971 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 180 mg/kg TOXIC EFFECTS : Behavioral - rigidity (including catalepsy) REFERENCE : CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 34,1634,1986 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 620 mg/kg TOXIC EFFECTS : Behavioral - ataxia Nutritional and Gross Metabolic - body temperature decrease REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 11,257,1961 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 34 mg/kg TOXIC EFFECTS : Behavioral - changes in motor activity (specific assay) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 5,421,1971

合成路线

122-00-9 ~% 728-88-1

文献：Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 42, # 12 p. 1125 - 1134

110-89-4 ~% 728-88-1

文献：Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 42, # 12 p. 1125 - 1134

1023-20-7 ~% 728-88-1

文献：Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 42, # 12 p. 1125 - 1134

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122-00-9 110-89-4 1023-20-7
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