Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Tolperisone
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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Name: Tolperisone
Chemical Name: 2-methyl-1-(4-methylphenyl)-3-piperidin-1-ylpropan-1-one
CAS Number: 728-88-1
Molecular Formula: C₁₆H₂₃NO
Molecular Weight: 245.36000
Catalog: API Circulatory system medication Peripheral vasodilator
Create Date: 2018-09-08 09:38:07
Modify Date: 2025-08-25 18:04:43

Name	2-methyl-1-(4-methylphenyl)-3-piperidin-1-ylpropan-1-one
Synonyms	tolperisone Besnoline (free base) EINECS 211-976-4 Roystajin (free base) Mydetone (RS)-tolperisone Mideton Mydocalm Mydeton Atmosgen (free base) MFCD00242995 2-methyl-1-(4-methylphenyl)-3-(1-piperidinyl)-1-propanone 2-methyl-3-piperidin-1-yl-1-p-tolyl-propan-1-one Menopatol 2,4'-dimethyl-3-piperidinopropiophenone

Density	1.004g/cm3
Boiling Point	373.9ºC at 760 mmHg
Molecular Formula	C₁₆H₂₃NO
Molecular Weight	245.36000
Flash Point	134.4ºC
Exact Mass	245.17800
PSA	20.31000
LogP	3.23760
Index of Refraction	1.526

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UH1575000

CHEMICAL NAME :: Propiophenone, 2,4'-dimethyl-3-piperidino-

CAS REGISTRY NUMBER :: 728-88-1

BEILSTEIN REFERENCE NO. :: 1285666

LAST UPDATED :: 199612

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C16-H23-N-O

MOLECULAR WEIGHT :: 245.40

WISWESSER LINE NOTATION :: T6NTJ A1Y1&VR D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1450 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 5,421,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 170 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 5,421,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 645 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 5,421,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1350 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 5,421,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Behavioral - rigidity (including catalepsy)

REFERENCE :: CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 34,1634,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 620 mg/kg

TOXIC EFFECTS :: Behavioral - ataxia Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 11,257,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 34 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 5,421,1971

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Literature: Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 42, # 12 p. 1125 - 1134

110-89-4

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Literature: Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 42, # 12 p. 1125 - 1134

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Literature: Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 42, # 12 p. 1125 - 1134

Precursor 3
122-00-9 110-89-4 1023-20-7
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