80-70-6

• 常用中文名：四甲基胍
• 常用英文名：Tetramethylguanidine
• CAS号：80-70-6
• 分子式：C₅H₁₃N₃
• 分子量：115.177
• 相关类别： 化学试剂 有机试剂 胍盐
• 发布时间：2018-02-05 08:00:00
• 更新时间：2024-01-02 12:39:35
• 主要用作聚氨基甲酸乙酯泡沫的催化剂，也用于锦纶(尼龙)、羊毛及其他蛋白质的均染四甲基胍化学品安全说明书(MSDS)
  【食入】
  不要催吐。如果受害人是清醒和警觉，给2-4 cupfuls，牛奶或水。立即就医。
  【吸入】
  立即就医。立即从现场至空气新鲜。如果没有呼吸，进行人工呼吸。如呼吸困难，给输氧。
  【皮肤】
  立即就医。立即用大量肥皂和水冲洗皮肤至少15分钟，同时脱去被污染的衣服和鞋子。
  【眼睛】
  立即冲洗眼睛用大量的水冲洗至少15分钟，并不时提起上下眼睑。获得医疗救助。、
  【处理】
  使用防火花的工具和防爆设备。不要吸入粉尘，蒸气，烟雾或气体。不要进入眼睛，皮肤或衣服上。只有在使用的化学通风柜.
  【个人防护】
  眼睛：戴化学护目镜和面罩的液体飞溅。皮肤：穿戴适当的防护手套，以防止皮肤接触。服装：穿适当的防护衣物，以减少与皮肤接触.
  【呼吸器】
  按照OSHA呼吸器条例29CFR 1910.134或欧洲标准EN 149。请务必使用一个NIOSH或欧洲标准EN 149批准的呼吸器必要时。
  【灭火】
  在压力需佩戴自给式呼吸器设备，MSHA / NIOSH（或同等学历），和全身防护服。会燃烧，如果发生火灾。为了扑灭火灾，使用水，干粉，化学泡沫，抗溶性泡沫。用于头孢半合成抗生素药物的生产，溶解7-ADCA、7-ACA、6-APA等弱酸性物质；聚氨基甲酸乙酯泡沫的催化剂；锦纶（尼龙）、羊毛及其他蛋白质的均染剂；有机合成催化剂等四甲基胍参数。

名称

• 中文名: 四甲基胍
• 英文名: Tetramethylguanidine
• 中文别名: -四甲基胍; N,N,N',N'-四甲基胍
• 英文别名: N,N,N',N'-TETRAMETHYLGUANIDINE; 1,1,3,3-Tetramethylguanidin; TETRAMETHYL GUANIDINE; 1,1,3,3-Tetramethylguayyniaine; N,N,N,N-Tetramethy1 Guanidine; 1,1,3,3-tetramethylgaunidine; MFCD00008323; 1,1,3,3-TMG; TMG; 1,1,3,3-tetramethyl-guanidine; EINECS 201-302-7

物化性质

• 密度: 0.9±0.1 g/cm3
• 沸点: 163.2±9.0 °C at 760 mmHg
• 熔点: -30 °C
• 分子式: C₅H₁₃N₃
• 分子量: 115.177
• 闪点: 60.0±0.0 °C
• 精确质量: 115.110947
• PSA: 30.33000
• LogP: 0.41
• 外观性状: 透明液体
• 蒸汽压: 2.1±0.3 mmHg at 25°C
• 折射率: 1.456
• 储存条件: 2-8°C
• 稳定性: Stable. Combustible. Incompatible with strong oxidizing agents, mineral and organic acids, carbon dioxide. Air-sensitive.
• 水溶解性: miscible
• 分子结构:

  1、 摩尔折射率：34.66

  2、 摩尔体积（m³/mol）：127.5

  3、 等张比容（90.2K）：292.7

  4、 表面张力（dyne/cm）：27.7

  5、 极化率（10^-24cm³）：13.74

• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:1

  3.氢键受体数量:1

  4.可旋转化学键数量:2

  5.互变异构体数量:无

  6.拓扑分子极性表面积30.3

  7.重原子数量:8

  8.表面电荷:0

  9.复杂度:75.7

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

• 更多:

  1. 性状：无色透明液体。

  2. 密度（g/mL,25/4℃）：0.915

  3. 相对蒸汽密度（g/mL,空气=1）：不确定

  4. 熔点（ºC）：不确定

  5. 沸点（ ºC, 常压）： 159-160 6. 沸点（ ºC, 1.46kPa ）：52～54℃ 7. 折射率： 1.4690 8. 闪点（ ºC ）：60 9. 比旋光度（ º ）：不确定

  10. 自燃点或引燃温度（ºC）：不确定

  11. 蒸气压（kPa,25ºC）：不确定

  12. 饱和蒸气压（kPa,60ºC）：不确定

  13. 燃烧热（KJ/mol）：不确定

  14. 临界温度（ºC）：不确定

  15. 临界压力（KPa）：不确定

  16. 油水（辛醇/水）分配系数的对数值：不确定

  17. 爆炸上限（%,V/V）：不确定

  18. 爆炸下限（%,V/V）：不确定

  19. 溶解性： 溶于水和有机溶剂。

MSDS

Name: 1 1 3 3-Tetramethylguanidine 99% (gc) Material Safety Data Sheet Synonym: Non CAS: 80-70-6 Section 1 - Chemical Product MSDS Name:1 1 3 3-Tetramethylguanidine 99% (gc) Material Safety Data Sheet Synonym:Non Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 80-70-6 1,1,3,3-Tetramethylguanidine 99% 201-302-7 Hazard Symbols: C Risk Phrases: 34 Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Causes burns.Corrosive. Potential Health Effects Eye: Causes eye burns. Skin: Causes skin burns. Ingestion: Causes gastrointestinal tract burns. Inhalation: Causes chemical burns to the respiratory tract. Inhalation may be fatal as a result of spasm, inflammation, edema of the larynx and bronchi, chemical pneumonitis and pulmonary edema. Chronic: Not available. Section 4 - FIRST AID MEASURES Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Ingestion: Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Get medical aid immediately. Inhalation: Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Notes to Physician: Treat as a caustic agent. Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Will burn if involved in a fire. Extinguishing Media: In case of fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Section 7 - HANDLING and STORAGE Handling: Use spark-proof tools and explosion proof equipment. Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Use only in a chemical fume hood. Storage: Keep away from sources of ignition. Store in a cool, dry place. Store in a tightly closed container. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 80-70-6: Personal Protective Equipment Eyes: Wear chemical goggles and a face shield if splashing is possible. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Liquid Color: Not available. Odor: Mild ammoniacal odor pH: Not available. Vapor Pressure: .26 hPa @ 25 deg C Viscosity: mPas 20 deg C Boiling Point: 160 - 162 deg C @ 760.00mm Hg Freezing/Melting Point: <-30 deg C Autoignition Temperature: 350 deg C ( 662.00 deg F) Flash Point: 60 deg C ( 140.00 deg F) Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Solubility in water: miscible with water Specific Gravity/Density: .9180g/cm3 Molecular Formula: C5H13N3 Molecular Weight: 115.18 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable at room temperature in closed containers under normal storage and handling conditions. Conditions to Avoid: Incompatible materials, ignition sources. Incompatibilities with Other Materials: Strong oxidizing agents - strong acids - acid chlorides - acid anhydrides. Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide. Hazardous Polymerization: Has not been reported. Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 80-70-6 unlisted. LD50/LC50: Not available. Carcinogenicity: 1,1,3,3-Tetramethylguanidine - Not listed by ACGIH, IARC, or NTP. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Shipping Name: CORROSIVE LIQUID, FLAMMABLE, N.O.S.* Hazard Class: 8 (3) UN Number: 2920 Packing Group: II IMO Shipping Name: CORROSIVE LIQUID, FLAMMABLE, N.O.S. Hazard Class: 8 (3) UN Number: 2920 Packing Group: II RID/ADR Shipping Name: CORROSIVE LIQUID, FLAMMABLE, N.O.S. Hazard Class: 8 UN Number: 2920 Packing group: II Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: C Risk Phrases: R 34 Causes burns. Safety Phrases: S 25 Avoid contact with eyes. S 36/37/39 Wear suitable protective clothing, gloves and eye/face protection. S 45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). WGK (Water Danger/Protection) CAS# 80-70-6: 2 Canada CAS# 80-70-6 is listed on Canada's DSL List. CAS# 80-70-6 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 80-70-6 is listed on the TSCA inventory. SECTION 16 - ADDITIONAL INFORMATION N/A

安全

• 符号: GHS02, GHS05, GHS07
• 信号词: Danger
• 危害声明: H226-H302-H314
• 警示性声明: P280-P305 + P351 + P338-P310
• 个人防护装备: Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
• 危害码 (欧洲): C:Corrosive;
• 风险声明 (欧洲): R10;R20/22;R34
• 安全声明 (欧洲): S26-S27-S36/37/39-S45-S16
• 危险品运输编码: UN 2920 8/PG 2
• WGK德国: 1
• 包装等级: II
• 危险类别: 8
• 海关编码: 2942000000

合成路线

1467-79-4 124-40-3 ~% 80-70-6

文献：Journal of Organic Chemistry, , vol. 72, # 11 p. 4067 - 4072

126661-09-4 ~% 1610-26-0 80-70-6

文献：Journal of the American Chemical Society, , vol. 98, p. 1870 - 1875

325774-15-0 ~% 7440-55-3 1333-74-0 80-70-6

文献：US6683198 B1, ; Page column 3-4 ;

124-40-3 ~% 80-70-6

文献：Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, , vol. 141, p. 141

506-78-5 124-40-3 ~% 80-70-6

文献：Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, , vol. 141, p. 141

上下游产品

上游产品  5
1467-79-4 124-40-3 126661-09-4 325774-15-0
506-78-5
下游产品  10
16574-54-2 90-94-8 210483-30-0 124-40-3
632-22-4 29166-74-3 2985-50-4 100-10-7
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海关

海关编码	2925290090
中文概述	2925290090 其他亚胺及其衍生物，以及它们的盐。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%
申报要素	品名, 成分含量, 用途
Summary	2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%