206055-67-6

• 常用中文名：1-(2’-O,4-C-甲桥-beta-D-呋喃核糖基)胸腺嘧啶
• 常用英文名：1-(2'-O-4-C-Methylene-beta-D-ribofuranosyl)thymine
• CAS号：206055-67-6
• 分子式：C₁₁H₁₄N₂O₆
• 分子量：270.23900
• 相关类别： 信号通路 细胞周期/DNA损伤 核苷抗代谢药/类似物
• 发布时间：2018-12-30 15:53:00
• 更新时间：2026-07-26 19:11:16
• 1-(2'-O-4-C-Methylene-beta-D-ribofuranosyl)thymine 是一种双环核苷。

名称

• 中文名: 1-(2’-O,4-C-甲桥-beta-D-呋喃核糖基)胸腺嘧啶
• 英文名: 1-(2'-O,4-C-Methylene-β-D-ribofuranosyl)thymine
• 中文别名: 1-(2'-O-4-C-亚甲桥基-BETA-D-呋喃核糖基)胸腺嘧啶; 5-甲基-2'-O,4'-C-亚甲基尿苷; 1-(2'-O,4-C-甲桥-BETA-D-呋喃核糖基)胸腺嘧啶; 1-(2'-O,4-C-甲桥-BETA-D-呋喃核糖基)胸腺嘧啶核苷; 1-((1S,3R,4R,7S)-7-羟基-1-(羟甲基)-2,5-二氧杂双环[2.2.1]庚烷-3-基)-5-甲基嘧啶-2,4(1H,3H)-二酮
• 英文别名: 5-Methyl-2'-O,4'-C-methyleneuridine; 2'-O-4'-C-Locked-5-Me-rU; (1S,3R,4R,7S)-7-hydroxy-1-hydroxymethyl-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane; 2'-O,4'-C-methylene-5-methyluridine; LNA-methyl-U; (1S,3R,4R,7S)-7-hydroxy-1-hydroxymethyl-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptane; LNA-5MeU; 2'-O,4'-C-methylenethymidine; 2,4(1H,3H)-PYRIMIDINEDIONE, 1-[2,5-ANHYDRO-4-C-(HYDROXYMETHYL)-ALPHA-L-LYXOFURANOSYL]-5-METHYL; 2,4(1H,3H)-Pyrimidinedione, 1-[2,5-anhydro-4-C-(hydroxymethyl)-α-L-lyxofuranosyl]-5-methyl- (9CI, ACI); 2'-O,4'-C-Methylene-5-Me-uridine; 1-[2,5-Anhydro-4-C-(hydroxymethyl)-alpha-L-lyxofuranosyl]-5-methyl-2,4(1H,3H)-pyrimidinedione; 5-Methyl-2’-O,4’-C-methyleneuridine; 2,4(1H,3H)-Pyrimidinedione, 1-[2,5-anhydro-4-C-(hydroxymethyl)-α-L-lyxofuranosyl]-5-methyl; 1-(2'-O,4-C-Methylene-beta-D-ribofuranosyl)thymine; LNA-002 1-(2'-O, 4-C-Methylene-β-D- ribofuranosyl)thyMine; 2'-O-4'-C-Locked-T; 5-methyl-2'-O,4'-C-methyleneuridine; 1-(2'-O-4-C-Methylene-b-D-ribofuranosyl)thymine; 1-[(1S,3R,4R,7S)-7-Hydroxy-1-(hydroxymethyl)-2,5-dioxabicyclo[2.2.1]htan-3-yl]-5-methylpyrimidine-2,4(1H,3H)-dione; 5-Methyl-2’-O,4’-C-methyleneuridine, LNA-5MeU

物化性质

• 密度: 1.598
• 分子式: C₁₁H₁₄N₂O₆
• 分子量: 270.23900
• 精确质量: 270.08500
• PSA: 113.78000

生物活性

• 描述: 1-(2'-O-4-C-Methylene-beta-D-ribofuranosyl)thymine 是一种双环核苷。
• 相关类别:
  信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物
  研究领域 >> 其他
• 参考文献:

  [1]. Sharma VK, et al. Chemoenzymatic convergent synthesis of 2'-O,4'-C-methyleneribonucleosides. J Org Chem. 2014 Jul 3;79(13):6336-41.

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