60731-46-6

• 常用中文名：依降钙素
• 常用英文名：(Des-Cys1,cyclo(Ser2-Asu7))-Calcitonin (eel) acetate salt
• CAS号：60731-46-6
• 分子式：C₁₄₈H₂₄₄N₄₂O₄₇
• 分子量：3363.774
• 相关类别： 原料药 水、电解质及酸碱平衡调节药 电解质平衡调节药
• 发布时间：2018-02-23 08:00:00
• 更新时间：2024-01-04 14:17:17
• Elcatonin (Carbocalcitonin) 是鳗鱼降钙素的一种合成类似物,可增加骨密度,抑制骨吸收并产生中枢镇痛作用

名称

• 中文名: 依降钙素
• 英文名: Carbocalcitonin
• 英文别名: N-{[(2S,5S,8S,11S,14S,17S)-5-(2-Amino-2-oxoethyl)-14-[(1R)-1-hydroxyethyl]-2,11-bis(hydroxymethyl)-8-isobutyl-3,6,9,12,15,23-hexaoxo-1,4,7,10,13,16-hexaazacyclotricosan-17-yl]carbonyl}-L-valyl-L-leucy ;lglycyl-L-lysyl-L-leucyl-L-seryl-L-glutaminyl-L-α-glutamyl-L-leucyl-L-histidyl-L-lysyl-L-leucyl-L-glutaminyl-L-threonyl-L-tyrosyl-L-prolyl-L-arginyl-L-threonyl-L-α-aspartyl-L-valylglycyl-L-ala nylglycyl-L-threonyl-L-prolinamide; HC-58; EINECS 262-393-7; Elcatonin Acetate; Elcatonin; (Aminosuberic acid 1,7)-eel calcitonin; 1,7-Dicarbacalcitonin,1-butanoic acid-26-L-aspartic acid-27-L-valine-29-L-alanine; Elcatoninum [INN-Latin]; Elcatonina [INN-Spanish]; 1,7-Dicarbacalcitonin (salmon),1-butanoic acid-26-L-aspartic acid-27-L-valine-29-L-alanine; L-Prolinamide, N-[[(2S,5S,8S,11S,14S,17S)-5-(2-amino-2-oxoethyl)-14-[(1R)-1-hydroxyethyl]-2,11-bis(hydroxymethyl)-8-(2-methylpropyl)-3,6,9,12,15,23-hexaoxo-1,4,7,10,13,16-hexaazacyclotricos-17-yl]carb ;onyl]-L-valyl-L-leucylglycyl-L-lysyl-L-leucyl-L-seryl-L-glutaminyl-L-α-glutamyl-L-leucyl-L-histidyl-L-lysyl-L-leucyl-L-glutaminyl-L-threonyl-L-tyrosyl-L-prolyl-L-arginyl-L-threonyl-L-α-asparty l-L-valylglycyl-L-alanylglycyl-L-threonyl-; Elcatonine [INN-French]

物化性质

• 密度: 1.5±0.1 g/cm3
• 分子式: C₁₄₈H₂₄₄N₄₂O₄₇
• 分子量: 3363.774
• 精确质量: 3361.799316
• PSA: 1435.94000
• LogP: -9.41
• 外观性状: 白色粉末
• 折射率: 1.659
• 储存条件: 2-8°C， 干燥

生物活性

• 描述: Elcatonin (Carbocalcitonin) 是鳗鱼降钙素的一种合成类似物,可增加骨密度,抑制骨吸收并产生中枢镇痛作用
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 代谢疾病
• 体内研究: Elcatonin(降钙素)(20u/kg；s.c.；奥沙利铂给药后2d)减轻奥沙利铂诱导的大鼠寒冷和机械性痛觉异常[2]。动物模型：雄性Sprague-Dawley大鼠,体重150-250g(奥沙利铂致痛觉超敏模型)[1]剂量：20u/kg皮下给药；奥沙利铂给药后2d结果：奥沙利铂致rtas寒颤减弱。
• 参考文献:

  [1]. Knopp JA, et al. Calcitonin for treating acute pain of osteoporotic vertebral compression fractures: a systematic review of randomized, controlled trials. Osteoporos Int. 2005;16(10):1281‐1290.

  [2]. Aoki M,et al. Comparison of the effects of single doses of elcatonin and pregabalin on oxaliplatin-induced cold and mechanical allodynia in rats. Biol Pharm Bull. 2014;37(2):322‐326.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : HS9270000 CHEMICAL NAME : 1,7-Dicarbacalcitonin (salmon), 1-butanoic acid-26-L-aspartic acid-27-L-valine-29-L-alanine- CAS REGISTRY NUMBER : 60731-46-6 LAST UPDATED : 199406 DATA ITEMS CITED : 10 MOLECULAR FORMULA : C148-H244-N42-O47 MOLECULAR WEIGHT : 3364.34 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >185 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,921,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >185 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,921,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >185 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,921,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >185 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,921,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >338 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,921,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >338 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,921,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >338 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,921,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >338 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,921,1982 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 18 ku/kg/26W-C TOXIC EFFECTS : Liver - other changes REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 19,915,1985 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 2240 units/kg/4W-I TOXIC EFFECTS : Kidney, Ureter, Bladder - urine volume decreased Kidney, Ureter, Bladder - other changes in urine composition Nutritional and Gross Metabolic - changes in calcium REFERENCE : YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 21,4477,1993

安全

• 危害码 (欧洲): Xn
• 海关编码: 2937190090

海关

海关编码	2937190090