CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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BZ8580500
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CHEMICAL NAME :
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Anisole, 2,4-diamino-
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CAS REGISTRY NUMBER :
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615-05-4
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BEILSTEIN REFERENCE NO. :
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2085522
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LAST UPDATED :
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199710
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DATA ITEMS CITED :
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26
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MOLECULAR FORMULA :
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C7-H10-N2-O
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MOLECULAR WEIGHT :
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138.19
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WISWESSER LINE NOTATION :
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ZR CZ DO1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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Standard Draize test
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
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Rodent - rabbit
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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460 mg/kg
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TOXIC EFFECTS :
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Behavioral - somnolence (general depressed activity) Behavioral - ataxia Skin and Appendages - hair
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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116 mg/kg
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TOXIC EFFECTS :
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Kidney, Ureter, Bladder - urine volume increased Kidney, Ureter, Bladder - other changes in urine composition
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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DOSE :
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65100 ug/kg
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SEX/DURATION :
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female 10 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)
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TYPE OF TEST :
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DNA damage
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TYPE OF TEST :
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Sister chromatid exchange
MUTATION DATA
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TYPE OF TEST :
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Mutation in mammalian somatic cells
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TEST SYSTEM :
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Rodent - mouse Lymphocyte
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REFERENCE :
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JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC. Volume(issue)/page/year: 1(1),87,1977 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 27,103,1982 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 27,103,1982 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-FINLAND;Carcinogen JAN 1993 OEL-GERMANY;Carcinogen JAN 1993 OEL-SWEDEN;Carcinogen JAN 1993 OEL-SWITZERLAND;Carcinogen JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO 2,4-DIAMINOANISOLE-air:CA lowest feasible conc. REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992
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