119410-05-8

• 常用中文名：6-羟基地氯雷他定
• 常用英文名：6-Hydroxy Desloratadine
• CAS号：119410-05-8
• 分子式：C₁₉H₁₉ClN₂O
• 分子量：326.82000
• 发布时间：2016-05-11 13:58:46
• 更新时间：2026-07-15 15:31:23

名称

• 中文名: 6-羟基地氯雷他定
• 英文名: 8-chloro-11-piperidin-4-ylidene-5,6-dihydrobenzo[1,2]cyclohepta[2,4-b]pyridin-6-ol
• 中文别名: 地氯雷他定杂质22; 地氯雷他定杂质42; 6-羟基去氯雷他定; 地氯雷他定6-羟基杂质(地氯雷他定杂质22)
• 英文别名: Desloratadine 6-Hydroxy Impurity; 8-chloro-11-piperidin-4-ylidene-5,6-dihydrobenzo[1,2]cyclohta[2,4-b]pyridin-6-ol; 5H-Benzo[5,6]cyclohta[1,2-b]pyridin-6-ol, 8-chloro-6,11-dihydro-11-(4-piperidinylidene); Desloratadine Impurity 42; Desloratadine Impurity 21; 8-chloro-11-(piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohta[1,2-b]pyridin-6-ol; 6-OH desloratadine; 8-Chloro-6,11-dihydro-11-(4-piperidinylidene)

物化性质

• 密度: 1.3g/cm3
• 沸点: 520.3ºC at 760 mmHg
• 分子式: C₁₉H₁₉ClN₂O
• 分子量: 326.82000
• 闪点: 268.5ºC
• 精确质量: 326.11900
• PSA: 45.15000
• LogP: 3.83860
• 蒸汽压: 1.19E-11mmHg at 25°C
• 折射率: 1.649

合成路线

119410-04-7 ~84% 119410-05-8

文献：Schering Corporation Patent: US4804666 A1, 1989 ;

119410-09-2 ~59% 119410-05-8 119410-11-6

文献：Schering Corporation Patent: US5422351 A1, 1995 ;

31251-41-9 ~% 119410-05-8

文献：Journal of Organic Chemistry, , vol. 55, # 10 p. 3341 - 3350

117811-16-2 ~% 119410-05-8

文献：Journal of Organic Chemistry, , vol. 55, # 10 p. 3341 - 3350

117811-22-0 ~% 119410-05-8

文献：Journal of Organic Chemistry, , vol. 55, # 10 p. 3341 - 3350

119410-11-6 ~% 119410-05-8

文献：Journal of Organic Chemistry, , vol. 55, # 10 p. 3341 - 3350

119410-09-2 ~% 119410-05-8

文献：Journal of Organic Chemistry, , vol. 55, # 10 p. 3341 - 3350

126063-19-2 ~% 119410-05-8

文献：Journal of Organic Chemistry, , vol. 55, # 10 p. 3341 - 3350

126063-20-5 ~% 119410-05-8

文献：Journal of Organic Chemistry, , vol. 55, # 10 p. 3341 - 3350

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31251-41-9 117811-16-2 117811-22-0 126063-19-2
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