571186-93-1

• 常用中文名：伊马替尼(哌啶)-N,N-二氧化物
• 常用英文名：iMatinib related substance B
• CAS号：571186-93-1
• 分子式：C₂₉H₃₁N₇O₃
• 分子量：525.602
• 相关类别： 原料药 抗肿瘤药 替尼类抗肿瘤药
• 发布时间：2016-04-01 14:56:36
• 更新时间：2026-08-14 03:18:38

名称

• 中文名: 伊马替尼进口标准杂质B
• 英文名: 4-[(4-methyl-1,4-dioxidopiperazine-1,4-diium-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide
• 中文别名: 伊马替尼杂质21(伊马替尼哌嗪DI - N -氧化物); 伊马替尼(哌啶基)-N,N-二氧化物; 伊马替尼(PIPERADINE)-N-N-二氧化物; 1-甲基-4-(4-((4-甲基-3-((4-(吡啶-3-基)嘧啶-2-基)氨基)苯基)氨基甲酰基)苄基)哌嗪1,4-二氧化物(伊马替尼杂质); 伊马替尼哌嗪-N,N-二氧化物(伊马替尼杂质72); 伊马替尼哌嗪-N,N-二氧化物; 杂质G二氧化杂质3; 4-[(4-甲基-1,4-二氧代-1-哌嗪基)甲基]-N-[4-甲基-3-[[4-(3-吡啶基)-2-嘧啶基]氨基]苯基]苯甲酰胺; 伊马替尼 (哌嗪)-N,N-二氧化物; 甲磺酸伊马替尼杂质G; 伊马替尼标准杂质B; 伊马替尼杂质V; 伊马替尼杂质21; 伊马替尼杂质21(伊马替尼哌嗪二氮氧化物); 1,4-二氧代伊马替尼
• 英文别名: Imatinib impurity 2/Imatinib (Piperidine)-N,N-DiOxide/1-Methyl-4-(4-((4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)cbamoyl)benzyl)piperazine 1,4-dioxide; Imatinib N-Oxide Impurity; iMatinib related substance B //BP; Imatinib Impurity 2; Imatinib Imp.B; 1-methyl-4-(4-((4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)cbamoyl)benzyl)piperazine 1,4-dioxide (Imatinib Impurity）; Imatinib (Piperidine)-1,4-oxide; Imatinib Impurity 21 (Imatinib Piperazine Di-N-Oxide); 4-[4-Methyl- 1.4-dioxidiperazin-1-yl] Methyl-N-[4 -Methyl-3-[[ 4-(pyridin-3-yl)pyriMidin-2- yl]amino]phenyl]benzaMide; Imatinib Impurity V; 4-[(4-Methyl-1,4-dioxido-1-piperazinyl)methyl]-N-(4-methyl-3-{[4-(3-pyridinyl)-2-pyrimidinyl]amino}phenyl)benzamide; IMatinib (Piperidine)-N,N-dioxide; RD-0071; iMatinibrelatedsubstanceB; "Imatinib Mesylate (Piperazine)-N,N-dioxide"; 1,4-dioxide iMatinib; Imatinib Impurity B; Imatinib (Piperazine)-N,N-dioxide; Benzamide, 4-[(4-methyl-1,4-dioxido-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]; Imatinib N1,N4-Dioxide; Imatinib D; Imatinib (Piperadine)-N-N-dioxide; 4-[(4-Methyl-1,4-dioxido-1-piperazinyl)Methyl]-N-[4-Methyl-3-[[4-(3-pyridinyl)-2-pyriMidinyl]amino]phenyl]benzaMide; Imatinib Mesylate ImpurityG

物化性质

• 分子式: C₂₉H₃₁N₇O₃
• 分子量: 525.602
• 精确质量: 525.248840
• PSA: 138.66000
• LogP: 0.46
• 储存条件: 2-8°C

合成路线

152459-95-5 ~% 571186-93-1

文献：Svrcek, Jiri; Syslova, Kamila; Stibal, David; Kuzma, Marek; Kacer, Petr Research on Chemical Intermediates, 2014 , vol. 40, # 2 p. 619 - 626

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