486460-23-5

• 常用中文名：(R)-(4-氧代-4-(3-(三氟甲基)-5,6-二氢-[1,2,4]三唑并[4,3-a]吡嗪-7(8H)-基)-1-(2,4,5-三氟苯基)丁-2-基)氨基甲酸叔丁酯
• 常用英文名：(R)-tert-Butyl (4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate
• CAS号：486460-23-5
• 分子式：C₂₁H₂₃F₆N₅O₃
• 分子量：507.42900
• 发布时间：2017-10-21 15:05:51
• 更新时间：2026-08-06 20:39:04
• 溶于甲苯

名称

• 中文名: N-Boc-西他列汀
• 英文名: tert-butyl N-[(2R)-4-oxo-4-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-1-(2,4,5-trifluorophenyl)butan-2-yl]carbamate
• 中文别名: (R)-(4-氧代-4-(3-(三氟甲基)-5,6-二氢-[1,2,4]三唑并[4,3-A]吡嗪-7(8H)-基)-1-(2,4,5-三氟苯基)丁-2-基)氨基甲酸叔丁酯; 磷酸西格列汀杂质7; 叔丁氧羰基-西他列汀; 西他列汀N-BOC 杂质; BOC-西他列汀; N-叔丁氧羰基-西他列汀; 西他列汀N-BOC; 西他列汀杂质22; N-BOC取代西格列汀; 西格列汀杂质 16; 西格列汀杂质03; 西他列汀杂质18(西他列汀N-BOC杂质); 化合物 (R)-TERT-BUTYL (4-OXO-4-(3-(TRIFLUOROMETHYL)-5,6-DIHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZIN-7(8H)-YL)-1-(2,4,5-TRIFLUOROPHENYL)BUTAN-2-YL)CBAMATE; 西格列汀 N-叔丁氧羰基杂质; N-BOC-西格列汀; 西格列汀杂质F
• 英文别名: tert-butyl (R)-(4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4] triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan- 2-yl)cbamate; Cbamic acid,[(1R)-3-[5,6-dihydro-3-(trifluoromethyl)-1,2,4; Sitagliptin Impurity 16; Sitagliptin-3; Sitagliptin Impurity 03; Cbamic acid, N-[(1R)-3-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-3-oxo-1-[(2,4,5-trifluorophenyl)methyl]propyl]-, 1,1-dimethylethyl ester; Cbamic acid,[(1R)-3-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-3-oxo-1-[(2,4,5-trifluorophenyl)methyl]propyl]-, 1,1-dimethylethylester; Sitagliptin Impurity 56; Sitagliptin impurity 10/Sitagliptin N-Boc Impurity/tert-butyl (R)-(4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)cbamate; Sitagliptin N-Boc IMpurity; Sitagliptin Impurity 18 (Sitagliptin N-Boc Impurity); Sitagliptin phosphate impurity 7; tert-butyl N-[(2R)-4-oxo-4-[3-(trifluoromethyl)-5H,6H,7H,8H-[ 1,2,4]triazolo[4,3-a]pyrazin-7-yl]-1-(2,4,5-trifluorop henyl)butan-2-yl]cbamate; Phenol,3-fluoro-8-iodo; Sitagliptin N-Boc impurities; (R)-[3-Oxo-1-(2,4,5-trifluoro-benzyl)-3-(3-trifluoromethyl-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)-propyl]-cbamic acid tert-butyl ester; (R)-tert-butyl (4-oxo-4-(3-(trifluoromethyl); Boc-Sitagliptin; tert-Butyl N-[(2R)-4-oxo-4-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-1-(2,4,5-trifluorophenyl)butan-2-yl]cbamate; Sitagliptin N-Boc; (R)-tert-Butyl (4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)cbamate; Sitagliptin Impurity 18 tert-butyl (R)-(4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5- trifluorophenyl)butan-2-yl)cbamate; N-Boc-Sitagliptin

物化性质

• 密度: 1.46±0.1 g/cm3(Predicted)
• 熔点: 188-191 °C
• 分子式: C₂₁H₂₃F₆N₅O₃
• 分子量: 507.42900
• 精确质量: 507.17100
• PSA: 92.84000
• LogP: 3.72480
• 外观性状: 固体
• 储存条件: 2-8°C， 密封， 干燥

安全

• 危害码 (欧洲): Xn

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