116817-11-9

• 常用中文名：(RS)-度洛西汀盐酸盐
• 常用英文名：Duloxetine hydrochloride
• CAS号：116817-11-9
• 分子式：C₁₈H₂₀ClNOS
• 分子量：333.875
• 相关类别： 原料药 神经系统用药 抗精神病药
• 发布时间：2018-07-25 20:34:36
• 更新时间：2024-01-08 11:03:36
• 抗抑郁药，治疗某些心境疾病如抑郁症和焦虑症以及缓解中枢性疼痛如糖尿病外周神经病性疼痛和妇女纤维肌痛等。

名称

• 中文名: 盐酸度洛西汀
• 英文名: N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-ylpropan-1-amine,hydrochloride
• 中文别名: (RS)-度洛西汀盐酸盐; (RS)-(-)-N-甲基-3-(1-萘氧基)-3-(2-噻吩)-丙胺盐酸盐; 消旋盐酸度洛西汀
• 英文别名: N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)propan-1-amine hydrochloride (1:1); N,N-dimethylamino-3-(1-naphthanyloxy)-3-(2-thienyl)-1-propanamine; (R,S)-Duloxetine hydrochloride; N,N-dimethyl-3-(1-naphthalenyloxy)-3-(thien-2-yl)propanamine; (RS)-N,N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine; N,N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine; N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)-1-propanamine hydrochloride (1:1); N-methyl-3-(1-naphthalenyloxy)-3-thiophen-2-yl-1-propanamine hydrochloride; N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-yl-propan-1-amine hydrochloride; 2-Thiophenepropanamine, N-methyl-γ-(1-naphthalenyloxy)-, hydrochloride (1:1); N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)-propanamine; (S)-duloxetine hydrochloride; Duloxetine hydrochloride; (RS)Duloxetine HCl

物化性质

• 沸点: 466.2ºC at 760 mmHg
• 熔点: 118-122ºC
• 分子式: C₁₈H₂₀ClNOS
• 分子量: 333.875
• 闪点: 235.7ºC
• 精确质量: 333.095398
• PSA: 49.50000
• LogP: 5.82380
• 蒸汽压: 7.23E-09mmHg at 25°C

安全

• 海关编码: 2934999090

合成路线

878757-08-5 ~81% 116817-11-9

文献：ZENTIVA, A.S. Patent: WO2006/45255 A1, 2006 ; Location in patent: Page/Page column 5 ;

916135-69-8 ~% 116817-11-9

文献：US2013/53579 A1, ; Paragraph 0070 ;

13636-02-7 321-38-0 ~82% 116817-11-9

文献：Chen, Shao-Rui; Li, Ai-Jun; Chen, Ming-Ming Asian Journal of Chemistry, 2012 , vol. 24, # 4 p. 1680 - 1684

1350249-48-7 ~% 116817-11-9

文献：US2013/53579 A1, ; Paragraph 0071-0074 ;

88-15-3 ~% 116817-11-9

文献：Bioorganic and medicinal chemistry letters, , vol. 13, # 24 p. 4477 - 4480

13196-35-5 ~% 116817-11-9

文献：Bioorganic and medicinal chemistry letters, , vol. 13, # 24 p. 4477 - 4480

34772-98-0 ~% 116817-11-9

文献：Asian Journal of Chemistry, , vol. 24, # 4 p. 1680 - 1684

海关

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%