66778-36-7

• 常用中文名：(±)-4-甲氧基-N-[2-[2-(1-甲基-2-哌啶基)乙基]苯基]苯甲酰胺
• 常用英文名：BENZAMIDE, 4-METHOXY-N-[2-[2-(1-METHYL-2-PIPERIDINYL)ETHYL]PHENYL]-
• CAS号：66778-36-7
• 分子式：C₂₂H₂₈N₂O₂
• 分子量：352.47000
• 相关类别： 研究领域 心血管疾病
• 发布时间：2018-12-20 10:46:04
• 更新时间：2024-01-05 17:55:01
• Encainide(MJ9067)是一种具有ⅠC活动。Encainide有可能用于威胁生命的室性心律失常、症状性室性心律失常和室上性心律失常的研究[1]。

名称

• 中文名: (±)-4-甲氧基-N-[2-[2-(1-甲基-2-哌啶基)乙基]苯基]苯甲酰胺
• 英文名: encainide
• 中文别名: 4-甲氧基-N-(2-(2-(1-甲基哌啶-2-基)乙基)苯基)苯甲酰胺
• 英文别名: MJ-9067[AS BASE]; MJ-9067; Enkaid; Encainida [spanish]; M-9067-1; 4-methoxy-N-<2-<2-(1-methyl-2-piperidinyl)ethyl>phenyl>benzamide; Encainide [french]; Encainidum; Enkade; [14C]-Encainide; Encainida; (-)-Encainide; BENZAMIDE, 4-METHOXY-N-[2-[2-(1-METHYL-2-PIPERIDINYL)ETHYL]PHENYL]-; 4-methoxy-2'-[2-(1-methyl-2-piperidyl)ethyl]benzanilide

物化性质

• 分子式: C₂₂H₂₈N₂O₂
• 分子量: 352.47000
• 精确质量: 352.21500
• PSA: 41.57000
• LogP: 4.37530

生物活性

• 描述: Encainide(MJ9067)是一种具有ⅠC活动。Encainide有可能用于威胁生命的室性心律失常、症状性室性心律失常和室上性心律失常的研究[1]。
• 相关类别:
  研究领域 >> 心血管疾病
  信号通路 >> 其他 >> 其他
• 体内研究: 恩卡肽(0.3,0.9,2.7 mg/kg；单剂量输注)可延长其浦肯野传导时间(HV间期)和心室内传导时间(QRS持续时间),但对窦房结恢复时间或房室结传导,或心房、房室结或心室心肌的难治性或QT间期无影响[1]。
• 参考文献:

  [1]. R N Brogden, et al. Encainide. A review of its pharmacological properties and therapeutic efficacy. Drugs. 1987 Nov;34(5):519-38.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : CV5521000 CHEMICAL NAME : Benzamide, 4-methoxy-N-(2-(2-(1-methyl-2-piperidinyl)ethyl)pheny l)-, (+-)- CAS REGISTRY NUMBER : 66778-36-7 BEILSTEIN REFERENCE NO. : 0497572 LAST UPDATED : 199612 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C22-H28-N2-O2 MOLECULAR WEIGHT : 352.52 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - infant DOSE/DURATION : 3289 ug/kg TOXIC EFFECTS : Cardiac - arrhythmias (including changes in conduction) Cardiac - change in rate REFERENCE : AEMED3 Annals of Emergency Medicine. (American College of Emergency Physicians, 1125 Executive Circle, Irving, TX 75038) Volume(issue)/page/year: 21,998,1992 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE/DURATION : 43 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Cardiac - pulse rate increase, without fall in BP Vascular - BP lowering not characterized in autonomic section REFERENCE : AJCDAG American Journal of Cardiology. (Technical Pub. Co., 875 Third Ave., New York, NY 10022) V.1- 1958- Volume(issue)/page/year: 57,878,1986 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE/DURATION : 3214 mg/kg/19H TOXIC EFFECTS : Cardiac - cardiomyopathy including infarction Cardiac - arrhythmias (including changes in conduction) REFERENCE : AHJOA2 American Heart Journal. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1925- Volume(issue)/page/year: 102,857,1981 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 2400 ug/kg/17H TOXIC EFFECTS : Cardiac - cardiomyopathy including infarction Cardiac - arrhythmias (including changes in conduction) REFERENCE : AHJOA2 American Heart Journal. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1925- Volume(issue)/page/year: 102,857,1981 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 1500 ug/kg TOXIC EFFECTS : Cardiac - arrhythmias (including changes in conduction) REFERENCE : AHJOA2 American Heart Journal. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1925- Volume(issue)/page/year: 102,857,1981 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 38100 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 281,277,1986