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66778-36-7

66778-36-7 structure
66778-36-7 structure
  • Name: BENZAMIDE, 4-METHOXY-N-[2-[2-(1-METHYL-2-PIPERIDINYL)ETHYL]PHENYL]-
  • Chemical Name: encainide
  • CAS Number: 66778-36-7
  • Molecular Formula: C22H28N2O2
  • Molecular Weight: 352.47000
  • Catalog: Research Areas Cardiovascular Disease
  • Create Date: 2018-12-20 10:46:04
  • Modify Date: 2024-01-05 17:55:01
  • Encainide (MJ9067) is an antiarrhythmic drug with class ⅠC activity. Encainide has the potential for life-threatening ventricular arrhythmias, symptomatic ventricular arrhythmias and supraventricular arrhythmias research[1].

Name encainide
Synonyms MJ-9067[AS BASE]
MJ-9067
Enkaid
Encainida [spanish]
M-9067-1
4-methoxy-N-<2-<2-(1-methyl-2-piperidinyl)ethyl>phenyl>benzamide
Encainide [french]
Encainidum
Enkade
[14C]-Encainide
Encainida
(-)-Encainide
BENZAMIDE, 4-METHOXY-N-[2-[2-(1-METHYL-2-PIPERIDINYL)ETHYL]PHENYL]-
4-methoxy-2'-[2-(1-methyl-2-piperidyl)ethyl]benzanilide
Description Encainide (MJ9067) is an antiarrhythmic drug with class ⅠC activity. Encainide has the potential for life-threatening ventricular arrhythmias, symptomatic ventricular arrhythmias and supraventricular arrhythmias research[1].
Related Catalog
In Vivo Encainide (0.3, 0.9, 2.7 mg/kg; infusion of single doses) prolongs His-Purkinje conduction time (HV interval) and intra-ventricular conduction time (QRS duration) but has no effect on sinus nodal recovery time or AV nodal conduction, or on refractoriness of atrium, AV node, or ventricular myocardium or on QT interval[1].
References

[1]. R N Brogden, et al. Encainide. A review of its pharmacological properties and therapeutic efficacy. Drugs. 1987 Nov;34(5):519-38.

Molecular Formula C22H28N2O2
Molecular Weight 352.47000
Exact Mass 352.21500
PSA 41.57000
LogP 4.37530

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CV5521000
CHEMICAL NAME :
Benzamide, 4-methoxy-N-(2-(2-(1-methyl-2-piperidinyl)ethyl)pheny l)-, (+-)-
CAS REGISTRY NUMBER :
66778-36-7
BEILSTEIN REFERENCE NO. :
0497572
LAST UPDATED :
199612
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C22-H28-N2-O2
MOLECULAR WEIGHT :
352.52

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - infant
DOSE/DURATION :
3289 ug/kg
TOXIC EFFECTS :
Cardiac - arrhythmias (including changes in conduction) Cardiac - change in rate
REFERENCE :
AEMED3 Annals of Emergency Medicine. (American College of Emergency Physicians, 1125 Executive Circle, Irving, TX 75038) Volume(issue)/page/year: 21,998,1992
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
43 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Cardiac - pulse rate increase, without fall in BP Vascular - BP lowering not characterized in autonomic section
REFERENCE :
AJCDAG American Journal of Cardiology. (Technical Pub. Co., 875 Third Ave., New York, NY 10022) V.1- 1958- Volume(issue)/page/year: 57,878,1986
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
3214 mg/kg/19H
TOXIC EFFECTS :
Cardiac - cardiomyopathy including infarction Cardiac - arrhythmias (including changes in conduction)
REFERENCE :
AHJOA2 American Heart Journal. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1925- Volume(issue)/page/year: 102,857,1981
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
2400 ug/kg/17H
TOXIC EFFECTS :
Cardiac - cardiomyopathy including infarction Cardiac - arrhythmias (including changes in conduction)
REFERENCE :
AHJOA2 American Heart Journal. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1925- Volume(issue)/page/year: 102,857,1981
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
1500 ug/kg
TOXIC EFFECTS :
Cardiac - arrhythmias (including changes in conduction)
REFERENCE :
AHJOA2 American Heart Journal. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1925- Volume(issue)/page/year: 102,857,1981
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
38100 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 281,277,1986