2260-08-4

• 常用中文名：醋替罗酯
• 常用英文名：Acetiromate
• CAS号：2260-08-4
• 分子式：C₁₅H₉I₃O₅
• 分子量：649.94200
• 相关类别： 研究领域 代谢疾病
• 发布时间：2018-08-09 11:00:33
• 更新时间：2024-02-05 12:25:08
• Acetiromate 是一种甲状腺素类似物。Acetiromate 是一种抗血脂药物,用于高脂血症。

名称

• 中文名: 醋替罗酯
• 英文名: 4-(4-acetyloxy-3-iodophenoxy)-3,5-diiodobenzoic acid
• 英文别名: Adecol; Acetyltriiodothyronine formic acid; TBF 43; Acetiromate

物化性质

• 密度: 2.351 g/cm3
• 沸点: 561.2ºC at 760 mmHg。 产品描述 安全性：
• 分子式: C₁₅H₉I₃O₅
• 分子量: 649.94200
• 闪点: 293.2ºC
• 精确质量: 649.75800
• PSA: 72.83000
• LogP: 4.91620
• 蒸汽压: 1.96E-13mmHg at 25°C
• 折射率: 1.724

生物活性

• 描述: Acetiromate 是一种甲状腺素类似物。Acetiromate 是一种抗血脂药物,用于高脂血症。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. S Kumaoka. Long-term administration of 3,5-diodo-4(3'-iodo4'-acetoxyphenoxy) benzoic acid (acetiromate) in hyperlipidemic patients. Endocrinol Jpn. 1974 Aug;21(4):355-60.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : DG8597700 CHEMICAL NAME : Benzoic acid, 3,5-diiodo-4-(4-hydroxy-3-iodophenoxy)-, acetate CAS REGISTRY NUMBER : 2260-08-4 LAST UPDATED : 198706 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C15-H9-I3-O5 MOLECULAR WEIGHT : 649.94 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 4600 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 5,383,1974 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 480 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 16,431,1974 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 520 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 5,383,1974 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3700 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 5,383,1974 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 5,383,1974 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2300 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 16,431,1974