235114-32-6

• 常用中文名：米卡芬净
• 常用英文名：micafungin
• CAS号：235114-32-6
• 分子式：C₅₆H₇₁N₉O₂₃S
• 分子量：1270.274
• 相关类别： 原料药 专科用药 眼科用药
• 发布时间：2018-08-20 17:06:53
• 更新时间：2026-06-30 20:52:59
• Micafungin (Mycamine; FK463) 是抗真菌化合物,能抑制真菌细胞壁中的1,3-beta-D-葡聚糖合酶。

名称

• 中文名: 米卡芬净
• 英文名: micafungin
• 中文别名: 5-((1S,2S)-2-((2R,9S,11R,12R,14AS,15S,16S,20S,25AS)-20-((R)-3-氨基-1-羟基-3-氧代丙基)-2,11,12,15-四羟基-6-((R)-1-羟乙基)-16-甲基-5,8,14,19,22,25-六氧代-9-(4-(5-(4-(戊氧基)苯基)异恶唑-3-基)苯甲酰氨基)二十四氢-1H-二吡咯并[2,1-C:2',1'-L][1,4,7,10,13,16]六氮杂环二十一烷-23-基)-1,2-二羟乙基)-2-羟基苯基 硫酸氢酯; 米卡芬净检测标准品; 米卡芬净酸; 2H11]-米卡芬净钠盐; 米卡芬净-D11; MICAFUNGIN米卡芬净; 米卡汾净; 5-((1S,2S)-2-((2R,9S,11R,12R,14aS,15S,16S,20S,25aS)-20-((R)-3-氨基-1-羟基-3-氧代丙基)-2,11,12,15-四羟基-6-((R)-1-羟乙基)-16-甲基-5,8,14,19,22,25-六氧代-9-(4-(5-(4-(戊氧基)苯基)异恶唑-3-基)苯甲酰氨基)二十四氢-1H-二吡咯并[2,1-c:2',1'-l][1,4,7,10,13,16]六氮杂环二十一烷-23-基)-1,2-二羟乙基)-2-羟基苯基 硫酸氢酯
• 英文别名: TIANFU-CHEM Micafungin; 5-[(1S,2S)-2-{(2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-20-[(1R)-3-Amino-1-hydroxy-3-oxopropyl]-2,11,12,15-tetrahydroxy-6-[(1R)-1-hydroxyethyl]-16-methyl-5,8,14,19,22,25-hexaoxo-9-[(4-{5-[4-(pentyloxy)phenyl]-1,2-oxazol-3-yl}benzoyl)amino]tetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-23-yl}-1,2-dihydroxyethyl]-2-hydroxyphenyl hydrogen sulfate; FK-463; {5-[(1S,2S)-2-[(3S,6S,9S,11R,15S,18S,20R,21R,24S,25S,26S)-3-[(1R)-2-cbamoyl-1-hydroxyethyl]-11,20,21,25-tetrahydroxy-15-[(1R)-1-hydroxyethyl]-26-methyl-2,5,8,14,17,23-hexaoxo-18-(4-{5-[4-(pentyloxy)phenyl]-1,2-oxazol-3-yl}benzamido)-1,4,7,13,16,22-hexaazatricyclo[22.3.0.0,13]htacosan-6-yl]-1,2-dihydroxyethyl]-2-hydroxyphenyl}oxidanesulfonic acid; MICAFUNGIN; Micafungin (FK463); PneuMocandin A0,1-[(4R,5R)-4,5-dihydroxy-N2-[4-[5-[4-(pentyloxy)phenyl]-3-isoxazolyl]benzoyl]-L-ornithine]-4-[(4S)-4-hydroxy-4-[4-hydroxy-3-(sulfooxy)phenyl]-L-threonine]; Micafungin Na; 5-((1S,2S)-2-((2R,9S,11R,12R,14aS,15S,16S,20S,25aS)-20-((R)-3-Amino-1-hydroxy-3-oxopropyl)-2,11,12,15-tetrahydroxy-6-((R)-1-hydroxyethyl)-16-methyl-5,8,14,19,22,25-hexaoxo-9-(4-(5-(4-(pentyloxy)phenyl)isoxazol-3-yl)benzamido)tetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-23-yl)-1,2-dihydroxyethyl)-2-hydroxyphenyl hydrogen sulfate; 5-((1s,2s)-2-((2r,6s,9s,11r,12r,14as,15s,16s,20s,23s,25as)-20-((r)-3-amino-1-hydroxy-3-oxopropyl)-2,11,12,15-tetrahydroxy-6-((r)-1-hydroxyethyl)-16-methyl-5,8,14,19,22,25-hexaoxo-9-(4-(5-(4-(pentyloxy)phenyl)isoxazol-3-yl)benzamido)tetracosahydro-1h-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-23-yl)-1,2-dihydroxyethyl)-2-hydroxyphenyl hydrogen sulfate; Micafungin-d11; Micafugin not sodium; R10H71BSWG; Micfungin; Micafungin(free acid); 2H11]-Micafungin Sodium salt; PubChem ID; Micafungin (Acid); Micafungin //BP; Mycamine; Pneumocandin A0,1-[(4R,5R)-4

物化性质

• 密度: 1.6±0.1 g/cm3
• 分子式: C₅₆H₇₁N₉O₂₃S
• 分子量: 1270.274
• 精确质量: 1269.438354
• PSA: 518.52000
• LogP: -7.49
• 折射率: 1.707
• 储存条件: 2-8℃

生物活性

• 描述: Micafungin (Mycamine; FK463) 是抗真菌化合物,能抑制真菌细胞壁中的1,3-beta-D-葡聚糖合酶。
• 相关类别:
  信号通路 >> 抗感染 >> 真菌
  研究领域 >> 感染
• 参考文献:

  [1]. Micafungin, From Wikipedia