29489-04-1

• 常用中文名：4-溴-1,2,3,4-四氢-1-(4-甲基苯磺酰基)-5H-1-苯并氮杂卓-5-酮
• 常用英文名：4-Bromo-1,2,3,4-tetrahydro-1-[(4-methylphenyl)sulfonyl]-5H-1-benzazepin-5-one
• CAS号：29489-04-1
• 分子式：C₁₀H₁₃Cl₃NO₃P
• 分子量：394.283
• 发布时间：2018-10-05 05:53:38
• 更新时间：2026-07-04 16:57:59

名称

• 中文名: 4-溴-1,2,3,4-四氢-1-(4-甲基苯磺酰基)-5H-1-苯并氮杂卓-5-酮
• 英文名: 4-bromo-1-(4-methylphenyl)sulfonyl-3,4-dihydro-2H-1-benzazepin-5-one
• 中文别名: 考尼伐坦杂质7; 考尼伐坦杂质H; 4-溴-1-(4-甲基苯磺酰基)-1,2,3,4-四氢-5H-1-苯并氮杂卓-5-酮; 考尼伐坦杂质20; 4-溴-1-甲苯磺酰基-1,2,3,4-四氢-5H-苯并[B]氮杂卓-5-酮; 盐酸考尼伐坦中间体; 科尼伐普坦杂质20; 4-溴-1-(甲苯-4-磺酰基)-1,2,3,4-四氢苯并[b]氮杂-5-酮
• 英文别名: 4-bromo-1-tosyl-1,2,3,4-tetrahydro-5H-benzo[b]azin-5-one; Conivaptan Impurity 5; 4-bromo-1-tosyl-3,4-dihydro-1Hbenzo[ b]azin-5(2H)-one; Conivaptan impurity H; 4-BROMO-1-(TOLUENE-4-SULFONYL)-1,2,3,4-TETRAHYDROBENZO[B]AZIN-5-ONE; Conivaptan-8; 5H-1-Benzazin-5-one,4-bromo-1,2,3,4-tetrahydro-1-[(4-methylphenyl)sulfonyl]; 4-Bromo-1,2,3,4-tetrahydro-1-[(4-methylphenyl)sulfonyl]-5H-1-benzazin-5-one; Conivaptan hydrochloride Impurity H; 4-Bromo-1-[(4-methylphenyl)sulfonyl]-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one; 4-Brom-2,3,4,5-tetrahydro-5-oxo-1-p-toluolsulfonylbenz<b>azepin; Conivaptan Impurity 20; 4-bromo-1-[(4-methylphenyl)sulfonyl]-1,2,3,4-tetrahydro-5H-1

物化性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 524.1±60.0 °C at 760 mmHg
• 熔点: 128-130ºC
• 分子式: C₁₀H₁₃Cl₃NO₃P
• 分子量: 394.283
• 闪点: 270.8±32.9 °C
• 精确质量: 393.003418
• PSA: 57.37000
• LogP: 2.98
• 蒸汽压: 0.0±1.4 mmHg at 25°C
• 折射率: 1.637

合成路线

24310-36-9 ~86% 29489-04-1

文献：Tsunoda, Takashi; Yamazaki, Atsuki; Mase, Toshiyasu; Sakamoto, Shuichi Organic Process Research and Development, 2005 , vol. 9, # 5 p. 593 - 598

50998-74-8 ~% 29489-04-1

文献：Tsunoda, Takashi; Tanaka, Akihiro; Mase, Toshiyasu; Sakamoto, Shuichi Heterocycles, 2004 , vol. 63, # 5 p. 1113 - 1122

68595-19-7 ~% 29489-04-1

文献：Tsunoda, Takashi; Tanaka, Akihiro; Mase, Toshiyasu; Sakamoto, Shuichi Heterocycles, 2004 , vol. 63, # 5 p. 1113 - 1122

134-20-3 ~% 29489-04-1

文献：Tsunoda, Takashi; Tanaka, Akihiro; Mase, Toshiyasu; Sakamoto, Shuichi Heterocycles, 2004 , vol. 63, # 5 p. 1113 - 1122

98-59-9 ~% 29489-04-1

文献：Tsunoda, Takashi; Tanaka, Akihiro; Mase, Toshiyasu; Sakamoto, Shuichi Heterocycles, 2004 , vol. 63, # 5 p. 1113 - 1122

105895-93-0 ~% 29489-04-1

文献：Tsunoda, Takashi; Tanaka, Akihiro; Mase, Toshiyasu; Sakamoto, Shuichi Heterocycles, 2004 , vol. 63, # 5 p. 1113 - 1122

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