2529-45-5

• 常用中文名：醋酸氟孕酮
• 常用英文名：Flurogestone Acetate
• CAS号：2529-45-5
• 分子式：C₂₃H₃₁FO₅
• 分子量：406.488
• 相关类别： 信号通路 G 蛋白偶联受体/G 蛋白 GNRH受体
• 发布时间：2018-08-06 18:36:22
• 更新时间：2026-07-08 17:46:03
• 醋酸氟孕酮是一种黄体酮化合物。醋酸氟孕酮通过抑制垂体中黄体生成激素(LH)的释放来抑制牛的排卵并同步发情周期[1]。

名称

• 中文名: 氟孕酮醋酸酯
• 英文名: Flugestone 17-Acetate
• 中文别名: 氟孕酮醋酸酯 标准品; 重组 Rat FGA蛋白 (His标签)-PDER100221; 醋酸氯孕酮; 氟孕酮醋酸酯,10 MM DMSO 溶液; 氟孕酮醋酸酯Flugestone 17-Acetate; 甲醇中氟孕酮醋酸酯; 醋酸氯孕酮溶液; 乙腈中醋酸氟孕酮溶液, 1000ΜG/ML; 氟孕酮17-醋酸酯; (8S,9R,10S,11S,13S,14S,17R)-17-乙酰基-9-氟-11-羟基-10,13-二甲基-3-氧代-2,3,6,7,8,9,10,11,12,13,14,15,16,17-十四氢-1H-环戊烷并[A]菲-17-基 乙酸酯; BIOTIN标记的纤维蛋白肽A抗体; 未包被人纤维蛋白原(FG) elisa试剂盒-E-UNEL-H0201; 猴纤维蛋白原(FG) elisa试剂盒-E-EL-MK2285; AP标记的纤维蛋白肽A抗体; 人纤维蛋白肽A(FPA) elisa试剂盒-E-EL-H2195; 醋酸氟孕酮(甾体); HRP标记的纤维蛋白肽A抗体; Fga蛋白; FGA 多克隆抗体-D-AB-10193L; 人 FG 抗体对-E-KAB-0256; 氟孕酮醋酸酯 醋酸氟孕酮; 重组 Mouse FGA/Fibrinogen A蛋白 (His标签)-PDEM100293; 人纤维蛋白原α链(FGA)ELISA试剂盒 YB72708Hu; 醋酸氯孕酮溶液,100PPM; 醋酸氟孕酮 Flugestone Acetate
• 英文别名: [(9R,17R)-17-Acetyl-9-fluoro-11-hydroxy-10,13-dimethyl-3-oxo-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl] acetate; flugestone acetate solution,100ppm; Flugestone Acetate in Methanol; lugestone 17-acetate; 17α-Acetoxy-9α-fluoro-11β-hydroxyprogesterone; cronolone; flugestone 17-acetate; Fluoroprogesterone acetate; 17a-Acetoxy-9a-fluoro-11b-hydroxyprogesterone; acetic acid [(8S,9R,10S,11S,13S,14S,17R)-17-acetyl-9-fluoro-11-hydroxy-10,13-dimethyl-3-oxo-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl] ester; Flugestone acetate solution in Acetonitrile, 1000μg/mL; 4-PREGNEN-9α-FLUORO-11β, 17-DIOL-3, 20-DIONE ACETATE; Fluprogesterone acetate; 17-(acetyloxy)-9-fluoro-11-hydroxy-20-dion(11-beta)-pregn-4-ene; [(8S,9R,10S,11S,13S,14S,17R)-17-acetyl-9-fluoro-11-hydroxy-10,13-dimethyl-3-oxo-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl] acetate; Pregn-4-ene-3,20-dione, 17-(acetyloxy)-9-fluoro-11-hydroxy-, (11β); Flugestone acetate; UNII-X60881643X; FLUGESTONE ACETATE; 17α-Acetoxy-9α-fluoro-11β-hydroxy-pregn-4-ene-3,20-dione; 4-PREGNEN-9-ALPHA-FLUORO-11-BETA, 17-DIOL-3,20-DIONE ACETATE; (8S,9R,10S,11S,13S,14S,17R)-17-Acetyl-9-fluoro-11-hydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate; fluorogesteroneacetate; Flurogestone; 9-Fluoro-11b,17-dihydroxypregn-4-ene-3,20-dione-17-acetate; MFCD00243094; NSC-65411; Flugeston-17-acetat; Fluorogestone acetate, 10 mM in DMSO; fga; (8s,9r,10s,11s,13s,14s,17r)-17-acetyl-9-fluoro-11-hydroxy-10,13-dimethyl-3-oxo-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl] Acetate; EINECS 219-776-9; 9-Fluoro-11β,17-dihydroxypregn-4-ene-3,20-dione 17-acetate; synchro-mate; 9-Fluoro-11b,17-dihydroxyprogesterone 17-Acetate; Progesterone, 9-fluoro-11β,17-dihydroxy-, 17-acetate; (11β)-17-(Acetyloxy)-9-fluoro-11-hydroxy-pregn-4-ene-3,20-dione; Progesterone Acetate; Flurogestone 17-acetate; Synchronate; FLuorogesterone acetater; FLUOROGESTONE ACETATE; (11β)-9-Fluoro-11-hydroxy-3,20-dioxopregn-4-en-17-yl acetate; Butop; Flugestone 17-acetate //BP; gyncro-mate; Pregn-4-ene-3,20-dione, 17-(acetyloxy)-9-fluoro-11-hydroxy-, (11.beta.); flurogestoneacetate; sc9880; 20-dione,9-fluoro-11-beta,17-dihydroxy-pregn-4-ene-17-acetate; Pregn-4-ene-3,20-dione, 9-fluoro-11-β,17-dihydroxy-, 17-acetate; Cronolone

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 526.7±50.0 °C at 760 mmHg
• 熔点: 267.5ºC
• 分子式: C₂₃H₃₁FO₅
• 分子量: 406.488
• 闪点: 272.3±30.1 °C
• 精确质量: 406.215546
• PSA: 80.67000
• LogP: 1.93
• 外观性状: 固体;White to Light yellow powder to crystal
• 蒸汽压: 0.0±3.1 mmHg at 25°C
• 折射率: 1.548
• 储存条件: 0-10°C;避免加热
• 分子结构:

  1、 摩尔折射率：103.76

  2、 摩尔体积（cm³/mol）：326.6

  3、 等张比容（90.2K）：858.3

  4、 表面张力（dyne/cm）：47.6

  5、 极化率（10-24cm3）：41.13

• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:1

  3.氢键受体数量:6

  4.可旋转化学键数量:3

  5.互变异构体数量:10

  6.拓扑分子极性表面积80.7

  7.重原子数量:29

  8.表面电荷:0

  9.复杂度:820

  10.同位素原子数量:0

  11.确定原子立构中心数量:7

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

生物活性

• 描述: 醋酸氟孕酮是一种黄体酮化合物。醋酸氟孕酮通过抑制垂体中黄体生成激素(LH)的释放来抑制牛的排卵并同步发情周期[1]。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> GNRH受体
  研究领域 >> 内分泌
• 参考文献:

  [1]. Freitas VJ, et al. Estrus synchronization in dairy goats: use of fluorogestone acetate vaginal sponges or norgestomet ear implants. Anim Reprod Sci. 1997 Apr;46(3-4):237-44.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : TU5024000 CHEMICAL NAME : Pregn-4-ene-3,20-dione, 9-fluoro-11-beta,17-dihydroxy-, 17-acetate CAS REGISTRY NUMBER : 2529-45-5 BEILSTEIN REFERENCE NO. : 3123549 LAST UPDATED : 199612 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C23-H31-F-O5 MOLECULAR WEIGHT : 406.54 WISWESSER LINE NOTATION : L E5 B666 OV MUTJ A1 BF CQ E1 FV1 FOV1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravaginal DOSE : 158 ug/kg SEX/DURATION : female 19 day(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - menstrual cycle changes or disorders Reproductive - Fertility - other measures of fertility Reproductive - Effects on Newborn - other neonatal measures or effects REFERENCE : JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 22,515,1970

合成路线

24320-12-5 ~% 2529-45-5

文献：Journal of the American Chemical Society, , vol. 81, p. 4432

24320-15-8 ~% 2529-45-5

文献：Journal of the American Chemical Society, , vol. 81, p. 4432

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