5598-53-8

• 常用中文名：L-天门冬氨酸钠
• 常用英文名：MAGNESIUM L-ASPARTATE
• CAS号：5598-53-8
• 分子式：C₄H₅MgNO₄
• 分子量：155.392
• 相关类别： 生物化工 氨基酸及其衍生物 其他氨基酸衍生物
• 发布时间：2018-09-19 09:36:53
• 更新时间：2024-01-02 15:20:29
• L-天冬氨酸二钠是一种氨基酸,可作为结肠靶向药物释放的合适前药[1][2]。

名称

• 中文名: L-天冬氨酸钠
• 英文名: Sodium L-aspartate
• 中文别名: L-天门冬氨酸钠
• 英文别名: ASPARTIC ACID MAGNESIUM SALT; Magnesium (2S)-2-aminosuccinate; L-ASPARTATE SODIUM; H-ASP-ONA; L-ASPARTIC ACID MAGNESIUM SALT; asparginic acid disodium salt; Natriumasparaginat; L-Aspartic acid, magnesium salt (1:1); sodium polyaspartate; H-ASP-OH NA; MonosodiumL-aspartate; aspartic acid disodium salt; L-Aspartic acid, magnesium salt (2:1); sodium aspartate; aspartatemonosodiumsalt; monosodiumaspartate; Sodium L-aspartic acid

物化性质

• 密度: 1.514g/cm3
• 沸点: 264.1ºC at 760mmHg
• 熔点: 270-271ºC
• 分子式: C₄H₅MgNO₄
• 分子量: 155.392
• 闪点: 113.5ºC
• 精确质量: 155.006897
• PSA: 78.62000
• 外观性状: 白色到灰白色 粉末
• 储存条件: 库房通风低温干燥,与氧化剂分开存放

生物活性

• 描述: L-天冬氨酸二钠是一种氨基酸,可作为结肠靶向药物释放的合适前药[1][2]。
• 相关类别:
  研究领域 >> 心血管疾病
• 靶点:

  Microbial Metabolite

  Human Endogenous Metabolite

• 参考文献:

  [1]. Hosoya K, et al. Blood-brain barrier produces significant efflux of L-aspartic acid but not D-aspartic acid: in vivo evidence using the brain efflux index method. J Neurochem. 1999 Sep;73(3):1206-11.

  [2]. Leopold CS, et al. In vivo pharmacokinetic study for the assessment of poly(L-aspartic acid) as a drug carrier for colon-specific drug delivery. J Pharmacokinet Biopharm. 1995 Aug;23(4):397-406.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : CI9450400 CHEMICAL NAME : Aspartic acid, disodium salt, L- CAS REGISTRY NUMBER : 5598-53-8 LAST UPDATED : 199712 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C4-H5-N-O4.2Na MOLECULAR WEIGHT : 177.08 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 6800 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 62,203,1990 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 500 mg/kg SEX/DURATION : male 1 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands REFERENCE : BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966- Volume(issue)/page/year: 32,410,1984 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 2 gm/kg SEX/DURATION : male 1 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - testes, epididymis, sperm duct REFERENCE : BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966- Volume(issue)/page/year: 32,410,1984 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 500 mg/kg SEX/DURATION : female 1 day(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - ovaries, fallopian tubes REFERENCE : BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966- Volume(issue)/page/year: 32,410,1984 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 2 gm/kg SEX/DURATION : female 1 day(s) pre-mating TOXIC EFFECTS : Reproductive - Effects on Newborn - live birth index (measured after birth) REFERENCE : BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966- Volume(issue)/page/year: 32,410,1984

安全

• 危害码 (欧洲): Xi