2884-51-7

• 常用中文名：地塞米松杂质29
• 常用英文名：21-o-acetyl dexamethasone 9,11-epoxide
• CAS号：2884-51-7
• 分子式：C₂₄H₃₀O₆
• 分子量：414.491
• 发布时间：2017-10-26 00:29:48
• 更新时间：2026-08-06 13:14:13

名称

• 中文名: 地塞米松杂质29
• 英文名: (9|A,11|A,16|A)-21-(Acetyloxy)-9,11-epoxy-17-hydroxy-16-methyl-pregna-1,4-diene-3,20-dione
• 中文别名: 去肟酶酮杂质F; 地塞米松醋酸盐杂质F; 醋酸地塞米松杂质F; 醋酸地塞米松杂质6; 2-((4AS,4BS,5AS,6AS,7R,8R,9AS,9BS)-7-羟基-4A,6A,8-三甲基-2-氧-2,4A,5A,6,6A,7,8,9,9A,9B,10,11-十二烷基旋流五[1,2]菲[4,4A-B]肟-7-基)-2-氧乙基醋酸盐 (醋酸地塞米松杂质)
• 英文别名: Dexamethasone Acetate Impurity F; 21-O-Acetyl Dexamethasone 9,11-Epoxide; (9β,11β,16α)-17-Hydroxy-16-methyl-3,20-dioxo-9,11-epoxypregna-1,4-dien-21-yl acetate; 21-O-Acetyl Dexamethasone 9,11-oxide（Desoximetasone Impurity F）; Desoximetasone Impurity F; Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-9,11-oxy-17-hydroxy-16-methyl-, (9β,11β,16α); Dexamethasone Acetate Impurity 6（Dexamethasone Acetate Impurity F）; (9β,11β,16α)-21-(Acetyloxy)-9,11-oxy-17-hydroxy-16-Methyl-pregna-1,4-diene-3,20-dione; 9,11oxy-17,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-acetate; 2-((4aS,4bS,5aS,6aS,7R,8R,9aS,9bS)-7-Hydroxy-4a,6a,8-trimethyl-2-oxo-2,4a,5a,6,6a,7,8,9,9a,9b,10,11-dodecahydrocyclopenta[1,2]phenanthro[4,4a-b]oxiren-7-yl)-2-oxoethyl acetate (Dexamethasone Acetate Impurity); Dexamethasone Acetate Impurity 6; 21-Acetoxy-3,20-dioxo-9beta,11beta-oxy-17alpha-hydroxy-16alpha-methyl-1,4-pregnadiene; 21-O-Acetyl DexaMethasone 9,11-oxide; Dexamethasone impurity 8/Dexamethasone Acetate Impurity F/2-((4aS,4bS,5aS,6aS,7R,8R,9aS,9bS)-7-hydroxy-4a,6a,8-trimethyl-2-oxo-2,4a,5a,6,6a,7,8,9,9a,9b,10,11-dodecahydrocyclopenta[1,2]phenanthro[4,4a-b]oxiren-7-yl)-2-oxoethyl acetate; 9,11beta-oxy-17-hydroxy-16alpha-methyl-3,20-dioxo-9beta-pregna-1,4-dien-21-yl Acetate

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 575.1±50.0 °C at 760 mmHg
• 分子式: C₂₄H₃₀O₆
• 分子量: 414.491
• 闪点: 195.8±23.6 °C
• 精确质量: 414.204254
• PSA: 93.20000
• LogP: 3.32
• 蒸汽压: 0.0±3.6 mmHg at 25°C
• 折射率: 1.591

合成路线

108-24-7 24916-90-3 ~95% 2884-51-7

文献：TARO PHARMACEUTICAL INDUSTRIES LTD.; CHERNIAK, Simon; CYJON, Rosa; OZER, Ilana; NUDELMAN, Igor Patent: WO2012/11106 A1, 2012 ; Location in patent: Page/Page column 19 ;

103466-44-0 ~% 2884-51-7

文献：Hulcoop, David G.; Shapland, Peter D.P. Steroids, 2013 , vol. 78, # 12-13 p. 1281 - 1287

37413-91-5 ~% 2884-51-7

文献：Hulcoop, David G.; Shapland, Peter D.P. Steroids, 2013 , vol. 78, # 12-13 p. 1281 - 1287

50-24-8 ~% 2884-51-7

文献：Hulcoop, David G.; Shapland, Peter D.P. Steroids, 2013 , vol. 78, # 12-13 p. 1281 - 1287

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