1246213-23-9

• 常用中文名：N-(2-(叔丁基)-5-羟基-4-(1-羟基-2-甲基丙烷-2-基)苯基)-4-氧代-1,4-二氢喹啉-3-羧酰胺
• 常用英文名：N-(2-(TERT-BUTYL)-5-HYDROXY-4-(1-HYDROXY-2-METHYLPROPAN-2-YL)PHENYL)-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXAMIDE
• CAS号：1246213-23-9
• 分子式：C₂₄H₂₈N₂O₄
• 分子量：408.49000
• 发布时间：2018-12-26 16:33:03
• 更新时间：2026-07-09 10:10:45

名称

• 中文名: N-(2-(叔丁基)-5-羟基-4-(1-羟基-2-甲基丙烷-2-基)苯基)-4-氧代-1,4-二氢喹啉-3-羧酰胺
• 英文名: N-[2-tert-butyl-5-hydroxy-4-(1-hydroxy-2-methylpropan-2-yl)phenyl]-4-oxo-1H-quinoline-3-carboxamide
• 中文别名: 伊瓦卡托杂质2; 依伐卡托相关杂质; 依伐卡托杂质2; 伊伐卡托杂质2; 羟甲基依伐卡托
• 英文别名: Ivacaftor Impurity 2; Hydroxymethyl IvacaftorQ: What is Hydroxymethyl Ivacaftor Q: What is the CAS Number of Hydroxymethyl Ivacaftor Q: What is the storage condition of Hydroxymethyl Ivacaftor Q: What e the applications of Hydroxymethyl Ivacaftor; N-[2-tert-butyl-5-hydroxy-4-(1-hydroxy-2-methylpropan-2-yl)phenyl]-4-oxo-1H-quinoline-3-cboxamide; Ivacaftor Hydroxy Metabolite; IvacaftorImpurity2-d6; N-(2-(tert-butyl)-5-hydroxy-4-(1-hydroxy-2-Methylpropan-2-yl)phenyl)-4-oxo-1,4-dihydroquinoline-3-cboxaMide; Ivacaftor Hydroxymethyl Impurity; 3-QuinolinecboxaMide, N-[2-(1,1-diMethylethyl)-5-hydroxy-4-(2-hydroxy-1,1-diMethylethyl)phenyl]-1,4-dihydro-4-oxo

物化性质

• 分子式: C₂₄H₂₈N₂O₄
• 分子量: 408.49000
• 精确质量: 408.20500
• PSA: 105.91000
• LogP: 4.43740

安全

• 海关编码: 2933499090

合成路线

873054-44-5 ~% 1246213-23-9 1246213-24-0

文献：VERTEX PHARMACEUTICALS INCORPORATED; DEMATTEI, John; LOOKER, Adam, R.; NEUBERT-LANGILLE, Bobbianna; TRUDEAU, Martin; ROEPER, Stefanie; RYAN, Michael, P.; YAP, Dahrika, Milfred Lao; KRUEGER, Brian, R.; GROOTENHUIS, Peter, D.J.; VAN GOOR, Frederick, F.; BOTFIELD, Martyn, C.; ZLOKARNIK, Gregor Patent: WO2010/108162 A1, 2010 ; Location in patent: Page/Page column 91-93 ;

上下游产品

上游产品  1
873054-44-5
下游产品  0

海关

海关编码	2933499090
中文概述	2933499090. 其他含喹琳或异喹啉环系的化合物〔但未进一步稠合的〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%