1246213-24-0

• 常用中文名：4-[[(1,4-二氢-4-氧代-3-喹啉)羰基]氨基]-5-(1,1-二甲基乙基)-2-羟基-α,α-二甲基-苯乙酸
• 常用英文名：2-(5-(TERT-BUTYL)-2-HYDROXY-4-(4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXAMIDO)PHENYL)-2-METHYLPROPANOIC ACID
• CAS号：1246213-24-0
• 分子式：C₂₄H₂₆N₂O₅
• 分子量：422.47400
• 发布时间：2019-01-01 09:50:19
• 更新时间：2026-08-15 11:43:38

名称

• 中文名: 4-[[(1,4-二氢-4-氧代-3-喹啉)羰基]氨基]-5-(1,1-二甲基乙基)-2-羟基-α,α-二甲基-苯乙酸
• 英文名: 2-[5-tert-butyl-2-hydroxy-4-[(4-oxo-1H-quinoline-3-carbonyl)amino]phenyl]-2-methylpropanoic acid
• 中文别名: 伊瓦卡托杂质1; 依伐卡托杂质1; 2-(5-(叔丁基)-2-羟基-4-(4-氧代-1,4-二氢喹啉-3-甲酰胺基)苯基)-2-甲基丙酸; 伊伐卡托杂质1; 4-[[(1,4-二氢-4-氧代-3-喹啉)羰基]氨基]-5-(1,1-二甲基乙基)-2-羟基-Α,Α-二甲基-苯乙酸; 伊伐卡托杂质; 依伐卡托羧酸
• 英文别名: Benzeneacetic acid, 4-[[(1,4-dihydro-4-oxo-3-quinolinyl)carbonyl]amino]-5-(1,1-diMethylethyl)-2-hydroxy-α,α-diMethyl; Ivacaftor Impurity 1; Benzeneacetic acid, 4-[[(1,4-dihydro-4-oxo-3-quinolinyl)carbonyl]amino]-5-(1,1-diMethylethyl)-2-hydroxy-alpha,alpha-diMethyl; Ivacaftor impurities5; Ivacaftor Cboxylic Acid; Ivacaftor Cboxylic Acid Impurity; Ivacaftor cboxylate; 2-(5-tert-butyl-2-hydroxy-4-(4-oxo-1,4-dihydroquinoline-3-cboxamido)phenyl)-2-methylpropanoic acid

物化性质

• 分子式: C₂₄H₂₆N₂O₅
• 分子量: 422.47400
• 精确质量: 422.18400
• PSA: 122.98000
• LogP: 4.52970

合成路线

873054-44-5 ~% 1246213-23-9 1246213-24-0

文献：VERTEX PHARMACEUTICALS INCORPORATED; DEMATTEI, John; LOOKER, Adam, R.; NEUBERT-LANGILLE, Bobbianna; TRUDEAU, Martin; ROEPER, Stefanie; RYAN, Michael, P.; YAP, Dahrika, Milfred Lao; KRUEGER, Brian, R.; GROOTENHUIS, Peter, D.J.; VAN GOOR, Frederick, F.; BOTFIELD, Martyn, C.; ZLOKARNIK, Gregor Patent: WO2010/108162 A1, 2010 ; Location in patent: Page/Page column 91-93 ;

1246213-41-1 ~% 1246213-24-0

文献：VERTEX PHARMACEUTICALS INCORPORATED; DEMATTEI, John; LOOKER, Adam, R.; NEUBERT-LANGILLE, Bobbianna; TRUDEAU, Martin; ROEPER, Stefanie; RYAN, Michael, P.; YAP, Dahrika, Milfred Lao; KRUEGER, Brian, R.; GROOTENHUIS, Peter, D.J.; VAN GOOR, Frederick, F.; BOTFIELD, Martyn, C.; ZLOKARNIK, Gregor Patent: WO2010/108162 A1, 2010 ; Location in patent: Page/Page column 75; 79 ;

上下游产品

上游产品  2
873054-44-5 1246213-41-1
下游产品  0